Results 81 to 90 of about 16,231 (234)
Acta Psychiatrica Scandinavica, EarlyView.ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian +3 more
wiley +1 more source
Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis [PDF]
, 2015 Corticosterone is known to accumulate in brain after various stressors including alcohol intoxication. Just as severe alcohol intoxication is typically required to impair memory formation only high concentrations of ethanol (60mM) acutely inhibit long ...
Izumi, Yukitoshi +2 more
core +4 more sources
Neurosteroids and Neuropathic Pain Management: basic evidence and therapeutic perspectives.
Frontiers in neuroendocrinology (Print), 2019 Complex mechanisms involved in neuropathic pain that represents a major health concern make its management complicated. Because neurosteroids are bioactive steroids endogenously synthesized in the nervous system, including in pain pathways, they appear ...
L. Meyer +3 more
semanticscholar +1 more source
Psychedelics, entactogens and psychoplastogens for depression and related disorders
British Journal of Pharmacology, EarlyView.Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley +1 more source
Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone
Frontiers in Cellular Neuroscience, 2014 A growing number of studies indicate that 3-alpha reduced neurosteroids are remarkable analgesics in various pain states. This is the case for allopregnanolone (AP), one of the most potent endogenous positive allosteric modulators of GABAA receptor ...
Pierrick ePoisbeau +6 more
doaj +1 more source
A clickable oxysterol photolabel retains NMDA receptor activity and accumulates in neurons [PDF]
, 2018 Oxysterol analogs that modulate NMDA receptor function are candidates for therapeutic development to treat neuropsychiatric disorders. However, the cellular actions of these compounds are still unclear.
Benz, Ann +6 more
core +3 more sources
Journal of Pharmacology and Experimental Therapeutics, 2019 Epilepsy is often treated with a combination of antiepileptic drugs. Although neurosteroids are potent anticonvulsants, little is known about their combination potential for the treatment of refractory epilepsy.
Shu-Hui Chuang, D. Reddy
semanticscholar +1 more source
Opening closed inward rectifier potassium channel doors
British Journal of Pharmacology, EarlyView.Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger +3 more
wiley +1 more source
Pharmaceutics, 2021 The central nervous system (CNS) is an important pharmacological target, but it is very effectively protected by the blood–brain barrier (BBB), thereby impairing the efficacy of many potential active compounds as they are unable to cross this barrier ...
Anima M. Schäfer +2 more
doaj +1 more source
A TSPO ligand is protective in a mouse model of multiple sclerosis. [PDF]
, 2013 Local production of neurosteroids such as progesterone and allopregnanolone confers neuroprotection in central nervous system (CNS) inflammatory diseases.
Chechneva, Olga V +5 more
core +2 more sources