Results 51 to 60 of about 65,558 (345)
Cyanobacterial Neurotoxin BMAA and Mercury in Sharks
Toxins, 2016 Sharks have greater risk for bioaccumulation of marine toxins and mercury (Hg), because they are long-lived predators. Shark fins and cartilage also contain β-N-methylamino-l-alanine (BMAA), a ubiquitous cyanobacterial toxin linked to neurodegenerative ...
Neil Hammerschlag +8 more
doaj +1 more source
Prediction of presynaptic and postsynaptic neurotoxins based on feature extraction
Mathematical Biosciences and Engineering, 2021 A neurotoxin is essentially a protein that mainly acts on the nervous system; it has a selective toxic effect on the central nervous system and neuromuscular nodes, can cause muscle paralysis and respiratory paralysis, and has strong lethality. According
Wen Zhu, Yuxin Guo, Quan Zou
doaj +1 more source
Therapy of Sialorrhea with Botulinum Neurotoxin
Neurological Therapeutics, 2019 Botulinum neurotoxin (BoNT) is considered the treatment of choice for various symptoms and diseases such as focal dystonia and focal spasticity. The effects of BoNT on the salivary glands have also been known for years, but their use was limited because ...
W. Jost +7 more
semanticscholar +1 more source
Identification of a novel botulinum neurotoxin gene cluster in Enterococcus
FEBS Letters, 2018 The deadly neurotoxins of Clostridium botulinum (BoNTs) comprise eight serotypes (A–G; X). The neurotoxin gene cluster encoding BoNT and its accessory proteins includes an operon containing an ntnh gene upstream of the boNT gene.
J. Brunt +3 more
semanticscholar +1 more source
New Neurotoxins on the Horizon [PDF]
Aesthetic Surgery Journal, 2008 Toxins isolated from lethal bacteria allow for safe, versatile, and minimally invasive interventions that have revolutionized the field of cosmetic and therapeutic treatments. Botulinum toxins are high-molecular weight proteins produced by Gram-positive, spore-forming Clostridial bacteria.
Joel L. Cohen, Scott R. Freeman
openaire +3 more sources
Characterization of Induced Pluripotent Stem Cell-derived Human Serotonergic Neurons
Frontiers in Cellular Neuroscience, 2017 In the brain, the serotonergic neurons located in the raphe nucleus are the unique resource of the neurotransmitter serotonin, which plays a pivotal role in the regulation of brain development and functions. Dysfunction of the serotonin system is present
Lining Cao +6 more
doaj +1 more source
Why Are Botulinum Neurotoxin-Producing Bacteria So Diverse and Botulinum Neurotoxins So Toxic?
Toxins, 2019 Botulinum neurotoxins (BoNTs) are the most lethal toxins among all bacterial, animal, plant and chemical poisonous compounds. Although a great effort has been made to understand their mode of action, some questions are still open.
B. Poulain, M. Popoff
semanticscholar +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Advances in the pathogenesis of Rett syndrome using cell models
Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 532-541, December 2022., 2022 Most Rett syndrome (RTT) patients are affected by the MECP2 gene mutations. And the mutations of MECP2 have wide effects on different cell types of nervous system, including neurons, astrocytes, oligodendrocytes and microglia, which always combined together to lead to abnormalities in the whole neural network.
Sijia Lu, Yongchang Chen, Zhengbo Wang
wiley +1 more source
Comprehensive Analysis of Neurotoxin-Induced Ablation of Dopaminergic Neurons in Zebrafish Larvae
Biomedicines, 2019 Neurotoxin exposure of zebrafish larvae has been used to mimic a Parkinson’s disease (PD) phenotype and to facilitate high-throughput drug screening. However, the vulnerability of zebrafish to various neurotoxins was shown to be variable.
Michael Kalyn +4 more
semanticscholar +1 more source