Results 51 to 60 of about 105,668 (383)

Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins

Toxins, 2016
To date, several families of peptide toxins specifically interacting with ion channels in scorpion venom have been described. One of these families comprise peptide toxins (called KTxs), known to modulate potassium channels.
Caroline M. Cremonez, Mohitosh Maiti, Steve Peigneur, Juliana Silva Cassoli, Alexandre A. A. Dutra, Etienne Waelkens, Eveline Lescrinier, Piet Herdewijn, Maria Elena de Lima, Adriano M. C. Pimenta, Eliane C. Arantes, Jan Tytgat   +11 more
doaj   +1 more source

Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]

, 1994
Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G., Ahnert-Hilger G., Bader M. F., Baumert M., Bittner M. A., Bittner M. A., Bittner M. A., Blasi J., Elferink L. A., Fischer G., Geppert M., Halpern J. L., Hess S. D., Jahn R., MANFRED GRATZL, Marqueze-Pouey B., McMahon H. T., Schiavo G., Schiavo G., Schiavo G., Schmidle T., Shirataki H., Shoji-Kasai Y., Stecher B., Thomas L., Trimble W. S., Walch-Solimena C., Wright J. F., Yoshida A.   +28 more
core   +1 more source

More than a Toxin: Protein Inventory of Clostridium tetani Toxoid Vaccines

Proteomes, 2019
Clostridium tetani is the etiological agent of tetanus, a life-threatening bacterial infection. The most efficient protection strategy against tetanus is a vaccination with the C.
Jens Möller, Max Edmund Kraner, Andreas Burkovski   +2 more
doaj   +1 more source

The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates [PDF]

, 1993
Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very ...
Burg, M., Horowski, R., Kalveram, K. T., Lange, Klaus W., Löschmann, P. A., Riederer, Peter, Sofic, E., Wachtel, H.   +7 more
core   +1 more source

AbobotulinumtoxinA (Dysport®), OnabotulinumtoxinA (Botox®), and IncobotulinumtoxinA (Xeomin®) Neurotoxin Content and Potential Implications for Duration of Response in Patients

Toxins, 2018
Botulinum neurotoxin type-A (BoNT-A) blocks the release of acetylcholine from peripheral cholinergic nerve terminals and is an important option for the treatment of disorders characterised by excessive cholinergic neuronal activity.
Malgorzata Field, A. Splevins, P. Picaut, M. van der Schans, J. Langenberg, D. Noort, K. Foster   +6 more
semanticscholar   +1 more source

Cyanobacterial Neurotoxin BMAA and Mercury in Sharks

Toxins, 2016
Sharks have greater risk for bioaccumulation of marine toxins and mercury (Hg), because they are long-lived predators. Shark fins and cartilage also contain β-N-methylamino-l-alanine (BMAA), a ubiquitous cyanobacterial toxin linked to neurodegenerative ...
Neil Hammerschlag, David A. Davis, Kiyo Mondo, Matthew S. Seely, Susan J. Murch, William Broc Glover, Timothy Divoll, David C. Evers, Deborah C. Mash   +8 more
doaj   +1 more source

A neurotoxin that specifically targets Anopheles mosquitoes

Nature Communications, 2019
Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets ...
Estefanía Contreras, G. Masuyer, N. Qureshi, Swati Chawla, H. Dhillon, H. Lee, Jian-wu Chen, P. Stenmark, S. Gill   +8 more
semanticscholar   +1 more source

Current Perspectives on Reducing the β-ODAP Content and Improving Potential Agronomic Traits in Grass Pea (Lathyrus sativus L.)

Frontiers in Plant Science, 2021
Grass pea is well-established as one of the most resilient and versatile crops that can thrive under extreme climatic circumstances such as cold, heat, drought, salt-affected soils, submergence, and excessive rainfall along with resistance to several ...
Arpita Das, Ashok K. Parihar, Surendra Barpete, Shiv Kumar, Sanjeev Gupta   +4 more
doaj   +1 more source

Exploitation of proteomics strategies in protein structure-function studies [PDF]

, 2003
Mass spectrometry plays a central role in structural proteomics, particularly in highly intensive structural genomics projects. This review paper reports some examples taken from recent work from the authors' laboratory and is aimed at showing that modem
BIROLO, LEILA, MARINO G., PUCCI, PIETRO, RUOPPOLO, MARGHERITA   +3 more
core   +1 more source

Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

Nature Communications, 2019
Antivenoms are fundamental in the therapy for snakebites. In elapid venoms, there are toxins, e.g. short-chain α-neurotoxins, which are quite abundant, highly toxic, and consequently play a major role in envenomation processes.
Guillermo de la Rosa, F. Olvera, Irving G. Archundia, B. Lomonte, A. Alagón, G. Corzo   +5 more
semanticscholar   +1 more source