Results 251 to 260 of about 292,316 (294)
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Carrier-mediated release of neurotransmitters
Trends in Neurosciences, 1993There is growing evidence that neurotransmitters can be released not only by exocytosis but also through the membrane carriers responsible for transmitter reuptake. Giulio Levi and Maurizio Raiteri review the in vitro and in vivo evidence supporting the existence of a carrier-mediated release for different classes of transmitters.
G, Levi, M, Raiteri
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Calcium Sensors of Neurotransmitter Release
2023Calcium (Ca2+) plays a critical role in triggering all three primary modes of neurotransmitter release (synchronous, asynchronous, and spontaneous). Synaptotagmin1, a protein with two C2 domains, is the first isoform of the synaptotagmin family that was identified and demonstrated as the primary Ca2+ sensor for synchronous neurotransmitter release ...
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2017
The biochemical and physiological processes of neurotransmitter release from an active zone, a specialized region of synaptic membrane, are examined. Synaptic vesicles containing neurotransmitters are docked at the active zone and then primed for release by SNARE complexes that bring them into extreme proximity to the plasma membrane.
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The biochemical and physiological processes of neurotransmitter release from an active zone, a specialized region of synaptic membrane, are examined. Synaptic vesicles containing neurotransmitters are docked at the active zone and then primed for release by SNARE complexes that bring them into extreme proximity to the plasma membrane.
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Molecular mechanisms in neurotransmitter release
Current Opinion in Neurobiology, 1991The vesicle hypothesis of neurotransmitter release was first formulated in the 1950s, but only recently have the molecular mechanisms involved in neurotransmitter release begun to be elucidated. This short review summarizes current concepts on neurosecretion and the available information on synaptic vesicle exocytosis.
M. Matteoli, P. De Camilli
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Molecular mechanisms of neurotransmitter release
Muscle & Nerve, 2001AbstractThe release of neurotransmitter from neurons represents one of the pivotal events in synaptic transmission. Neurotransmitters are released from synaptic vesicles in presynaptic neurons in response to neural activity, diffuse across the synaptic cleft, and bind specific receptors in order to bring about changes in postsynaptic neurons.
E A, Fon, R H, Edwards
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The bioenergetics of neurotransmitter release
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1991Synaptosomal energetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245 A. Na + and K+-circuits across the synaptosomal plasma membrane . . . . . . . . . . . . . . . . . . . . . 246 B. The thermodynamics of Na + coupled transmitter carriers . . . . . . . . . . . . . . . . . . . . . . . . . 248
H T, McMahon, D G, Nicholls
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Storage and release of neurotransmitters
Cell, 1993Because synaptic vesicles and secretory granules are simple in composition and easy to purify, many of their protein components have been identified and often sequenced. Attempts are underway to link the small number of membrane proteins to the small number of functions the vesicles perform.
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Neurotransmitter release at fast synapses
The Journal of Membrane Biology, 1994As stated at the beginning of this review, the mechanism of neurotransmitter release is not yet known. Keeping this in mind, we shall, nevertheless, attempt to speculate and outline a possible scenario of events as it emerges from the foregoing discussion.
H, Parnas, I, Parnas
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Imaging of endogenous neurotransmitter release
Journal of Neuroscience Methods, 1998A method for imaging endogenous release of two common neurotransmitters from tissue slices is described. This detection employs fluorometric, enzymatic assays for glutamate and for GABA, the progress of which is directly monitored by a cooled CCD camera.
G S, Ayoub, S, Grutsis, H, Simko
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Molecular analysis of neurotransmitter release
Essays in Biochemistry, 1998The synaptic vesicle cycle can now be subdivided into a series of defined steps. These are the tethering of the SSV at the active site of the presynaptic membrane, followed by docking and by an ATP-dependent phase, termed priming. Fusion of the primed SSV with the plasma membrane is triggered by CA2+ entry through specific Ca2+ channels.
G, Schiavo, G, Stenbeck
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