Results 81 to 90 of about 12,090 (225)

Loss‐of‐Function of p21‐Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects

Advanced Science, 2023
Closure of the neural tube represents a highly complex and coordinated process, the failure of which constitutes common birth defects. The serine/threonine kinase p21‐activated kinase 2 (PAK2) is a critical regulator of cytoskeleton dynamics; however ...
Yan Wang, Kaifan Zhang, Jin Guo, Shuyan Yang, Xiaohui Shi, Jinrong Pan, Zheng Sun, Jizhen Zou, Yi Li, Yuanyuan Li, Tianda Fan, Wei Song, Fang Cheng, Cheng Zeng, Jinchen Li, Ting Zhang, Zhong Sheng Sun   +16 more
doaj   +1 more source

Prenatal Diagnosis to Postnatal Outcomes of Saccular Forms of Closed Spina Dysraphism: A Single Center Retrospective Study

Prenatal Diagnosis, Volume 46, Issue 2, Page 219-228, February 2026.
ABSTRACT Objective To describe prenatal imaging findings and postnatal outcomes in fetuses diagnosed with saccular forms of closed spinal dysraphism (CSD). Methods This retrospective single‐centre study included fetuses diagnosed with non‐genetic, non‐syndromic CSD between January 2018 and June 2023.
Yada Kunpalin, Jennifer Quon, Abby Varghese, Michael Chua, Samer Maher, Abhaya V. Kulkarni, Tim Van Mieghem, Shiri Shinar, Elka Miller   +8 more
wiley   +1 more source

Neurulation: coordinating cell polarisation and lumen formation [PDF]

The EMBO Journal, 2012
Brain morphogenesis in zebrafish is initiated by the convergence movements of yet apicobasally unpolarised neural progenitors towards the dorsal side of the embryo, where they accumulate along the forming body axis giving rise to the neural rod. It is only after the formation of the neural rod, that the neurocoel is formed by cavitation (Papan and ...
Julien, Compagnon, Carl-Philipp, Heisenberg   +1 more
openaire   +2 more sources

The Amphioxus SoxB Family: Implications for the Evolution of Vertebrate Placodes [PDF]

, 2007
Cranial placodes are regions of thickened ectoderm that give rise to sense organs and ganglia in the vertebrate head. Homologous structures are proposed to exist in urochordates, but have not been found in cephalochordates, suggesting the first chordates
Bronner-Fraser, Marianne, Meulemans, Daniel   +1 more
core   +1 more source

Biotechnical Multiscale Engineering of Scaffolds for Stem Cell and Organoid Research

Small, Volume 22, Issue 12, 25 February 2026.
Biotechnical multiscale engineering consideration of geometric and structural parameters, which is called biotechnical multiscale engineering, has an influence on stem cell development and organogenesis comparable to that of molecular genetics and biochemical parameters.
Merle‐Johanna Küstner, Christian Marx, Peter beim Graben, Serafim Rodrigues, Jörg Hampl, Frank Weise, Michael Gebinoga, Leon Kaysan, Maren Klett, Dana Brauer, Gregor Schlingloff, Doris Heinrich, Insa Sigrid Schroeder, Andreas Schober   +13 more
wiley   +1 more source

Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice [PDF]

, 2018
Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass is ...
A Kamalakar, A Trinh, AJ Copp, AJ Copp, AS Findlay, B Wang, BA Alman, C Cooper, C Hartmann, CF Davey, CH Chen, D Karasik, D Szklarczyk, DG Winkler, DJ Epstein, DM Juriloff, E Canalis, E Nikolopoulou, EM Curtis, GH Li, GL Galea, GL Galea, GL Galea, GL Galea, H Marreiros, H Yin, HF Zheng, IR Orriss, IR Orriss, JK Morris, JN Murdoch, K Estrada, KC Keller, KS Joeng, L D’Andrea, LJ Martin, LL Yates, LL Yates, M Akbar, M Kalogeropoulos, ME Ross, MJ Anderson, MJ Harris, MJ Harris, MR Dohn, NC Nowlan, P Andre, P Elms, P Ybot-Gonzalez, P Ybot-Gonzalez, R Klootwijk, R Xu, S Babayeva, S Li, S Maere, SA Brown, SE Taylor, SJ Conway, T Dodge, T Yang, UM Ayturk, V Martinelli, W Yang, Y Erdem, Y Koyabu, Y Lei, Z Kibar   +66 more
core   +3 more sources

The tandem–random transition of cellular patterning: proposed roles of N‐cadherin‐based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus

Biological Reviews, Volume 101, Issue 1, Page 268-278, February 2026.
ABSTRACT Intervertebral disc degeneration (IDD) can contribute to lower back and neck pain. In IDD, the most affected component of the intervertebral disc is the nucleus pulposus (NP). Derived from the notochord, where cells are organized into a tandem configuration, young NP cells cluster in three‐dimensional (3D) networks embedded in a gelatinous ...
Xiangyun Wei, Nam Vo, Gwendolyn A. Sowa
wiley   +1 more source

A rare complex association of dermal sinus tract, dermoid cyst, filum terminale lipoma, tethered spinal cord and syringomyelia: A case report and literature review

Interdisciplinary Neurosurgery
Background: Dermal sinus tract is a rare type of spinal dysraphism. It is usually associated with other types of spinal congenital anomalies. This work shows the rare co-occurrence of primary and secondary neurulation defect in a single patient.
Mekdes Musie Awano, Eyob Zenebe Wendimagegnehu   +1 more
doaj   +1 more source

Neural Tube Defects

Pediatric Neurology Briefs, 1988
In an overview of neural tube defects (NTD’s), Dr RJ Lemire of the Dept Pediatrics, Univ of Washington and Children’s Hospital, Seattle, WA, divides them into two major groups: (1) neurulation and (2) postneurulation defects.
J Gordon Millichap
doaj   +1 more source

Rhythm Processing Across Development: Origins, Links to Language Processing, and Perspectives for Intervention

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
ABSTRACT A wealth of research has investigated rhythm processing in music and speech, revealing shared cognitive and neural correlates and potential transfer effects, as evidenced by shared benefits and shared processing difficulties, as well as effects of stimulation and training programs.
Barbara Tillmann, Usha Goswami, Sahar Moghimi   +2 more
wiley   +1 more source