Results 11 to 20 of about 3,927 (157)

Role of HO/CO in the Control of Peripheral Circulation in Humans [PDF]

International Journal of Hypertension, 2012
Experimental studies show that the heme oxygenase/carbon monoxide system (HO/CO) plays an important role in the homeostasis of circulation and in the pathophysiology of hypertension.
David Sacerdoti, Despina Mania, Paola Pesce, Silvia Gaiani, Angelo Gatta, Massimo Bolognesi   +5 more
doaj   +4 more sources

Physalis angulata Leaf Ethanol Extract Reduces Oxidative Stress and Improves Endothelial Progenitor Cells in L-NAME-Induced Hypertensive Rats [PDF]

Hayati Journal of Biosciences, 2022
This study aimed to evaluate the effects of ciplukan (Physalis angulata L.) leaf ethanol extract on L-NG-nitroarginine methyl ester (L-NAME)-induced hypertensive rats. We randomly divided twenty-five Wistar rats into five groups.
Dian Nugrahenny, Nur Permatasari, Setyawati Soeharto, Indriati Dwi Rahayu, Edwin Widodo, Karyono Mintaroem, Hidayat Sujuti, Retty Ratnawati, Elly Mayangsari, Dicky Faizal Irnandi, Lavina Sofia Ardani, Tika Ardhini Wardoyo, Nathania Bella Claresta, Nura Fattah Cantika Yoga, Adinda Chika Anindita, Niarti Ulan Sari Siarnu, Fardizia Putri Alia   +16 more
doaj   +3 more sources

Effects of Diclofenac, L-NAME, L-Arginine, and Pentadecapeptide BPC 157 on Gastrointestinal, Liver, and Brain Lesions, Failed Anastomosis, and Intestinal Adaptation Deterioration in 24 Hour-Short-Bowel Rats. [PDF]

PLoS ONE, 2016
Stable gastric pentadecapeptide BPC 157 was previously used to ameliorate wound healing following major surgery and counteract diclofenac toxicity. To resolve the increasing early risks following major massive small bowel resectioning surgery, diclofenac
Nermin Lojo, Zarko Rasic, Anita Zenko Sever, Danijela Kolenc, Darko Vukusic, Domagoj Drmic, Ivan Zoricic, Marko Sever, Sven Seiwerth, Predrag Sikiric   +9 more
doaj   +4 more sources

Alterations of myocardial ketone metabolism in heart failure with preserved ejection fraction (HFpEF). [PDF]

ESC Heart Fail
Abstract Introduction Cardiac energy metabolism is disrupted in heart failure with preserved ejection fraction (HFpEF), as characterized by a switch from glucose oxidation towards fatty acid oxidation. However, although oxidation of ketones is an important source of ATP it remains unclear how the heart oxidizes ketones in HFpEF.
Sun Q, Wagg CS, Wong N, Wei K, Ketema EB, Zhang L, Fang L, Seubert JM, Lopaschuk GD.   +8 more
europepmc   +2 more sources

Correlational Study of Aminopeptidase Activities between Left or Right Frontal Cortex versus the Hypothalamus, Pituitary, Adrenal Axis of Spontaneously Hypertensive Rats Treated with Hypotensive or Hypertensive Agents. [PDF]

Int J Mol Sci, 2023
Supplementary Materials: The supporting information can be downloaded at: https://www.mdpi. com/article/10.3390/ijms242116007/s1It has been suggested that the neuro-visceral integration works asymmetrically and that this asymmetry is dynamic and ...
Prieto I, Segarra AB, Banegas I, Martínez-Cañamero M, Durán R, Vives F, Domínguez-Vías G, Ramírez-Sánchez M.   +7 more
europepmc   +6 more sources

Glutamine enhances endothelial cell survival and vasodilation by increasing glutathione to reduce oxidative stress. [PDF]

Physiol Rep
Abstract Cardiovascular disease is exacerbated by diabetes through hyperglycemia‐induced endothelial dysfunction, which arises from oxidative stress. Glutamine is postulated to decrease oxidative stress; however, its effect on endothelial dysfunction in hyperglycemia is unknown.
Kheradmand M, Sangha G, Sissons CM, Sun M, Zhou X, Smith LV, Bauer M, Chen C, Clyne AM.   +8 more
europepmc   +2 more sources

Combination of angiotensin II andl-N^G-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2016
Mitochondrial dysfunction has been implicated as a cause of energy deprivation in heart failure (HF). Herein, we tested individual and combined effects of two pathogenic factors of nonischemic HF, inhibition of nitric oxide synthesis [with l- NG-nitroarginine methyl ester (l-NAME)] and hypertension [with angiotensin II (AngII)], on myocardial ...
Dale J, Hamilton, Aijun, Zhang, Shumin, Li, Tram N, Cao, Jessie A, Smith, Indira, Vedula, Andrea M, Cordero-Reyes, Keith A, Youker, Guillermo, Torre-Amione, Anisha A, Gupte   +9 more
openaire   +2 more sources

Novel enhancers of guanylyl cyclase‐A activity acting via allosteric modulation

British Journal of Pharmacology, Volume 180, Issue 24, Page 3254-3270, December 2023., 2023
Abstract Background and Purpose Guanylyl cyclase‐A (GC‐A), activated by endogenous atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), plays an important role in the regulation of cardiovascular and renal homeostasis and is an attractive drug target. Even though small molecule modulators allow oral administration and longer half‐life,
Henriette Andresen, Cristina Pérez‐Ternero, Jerid Robinson, Deborah M. Dickey, Adrian J. Hobbs, Lincoln R. Potter, Finn Olav Levy, Alessandro Cataliotti, Lise Román Moltzau   +8 more
wiley   +1 more source

CNS sites controlling the gastric pyloric sphincter: Neuroanatomical and functional study in the rat

Journal of Comparative Neurology, Volume 531, Issue 15, Page 1562-1581, October 2023., 2023
The dorsal motor nucleus of the vagus (DMV) of the brainstem is a crucial region that modulates the activity of gastric function. The pyloric sphincter at the gastroduodenal junction, which regulates the flow of partially digested food from the stomach, is mediated by the nucleus in a site‐specific manner.
Janell Richardson, Ghazaul Dezfuli, Allen W. Mangel, Richard A. Gillis, Stefano Vicini, Niaz Sahibzada   +5 more
wiley   +1 more source

Tumor Necrosis Factor - Related Apoptosis-Inducing Ligand (TRAIL) promotes angiogenesis and ischemia- induced neovascularization via NADPH Oxidase 4 (NOX4) and Nitric Oxide - dependent mechanisms [PDF]

, 2015
Background — Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has the ability to inhibit angiogenesis by inducing endothelial cell death, as well as being able to promote pro- angiogenic activity in vitro.
Azahri, N, Cartland, S, Di Bartolo, B, Gentile, C, Griffith, T, Kavurma, M, Prado-Lourenco, L, Ravindran, J, Thai, T, Thomas, S, Yeung, A   +10 more
core   +5 more sources