Results 21 to 30 of about 3,927 (157)
Journal of Extracellular Vesicles, Volume 12, Issue 5, May 2023., 2023 Am produced EVs in the GI tract. AmEVs can cross the intestinal barrier and reach the placenta in dams. AmEVs can interact with trophoblasts to improve trophoblast proliferation, migration and invasion by activating the EGFR‐PI3K‐AKT signalling pathway, which further promotes SpA remodelling. The graphical abstract was created with BioRender.com.
Yun Chen +15 more
wiley +1 more source
Nitric Oxide Synthase Dependency in Hydroxyurea Inhibition of Erythroid Progenitor Growth [PDF]
, 2021 Hydroxyurea (HU) causes nitric oxide (NO) bioactivation, acting as both a NO donor and a stimulator of NO synthase (NOS). To examine whether HU effects are NO mediated by chemical degradation or enzymatic induction, we studied human and mouse erythroid ...
Mitrović-Ajtić, Olivera +5 more
core +1 more source
Journal of Cell Communication and Signaling, Volume 17, Issue 1, Page 151-165, March 2023., 2023 Graphical abstract Xing et al. (2022) investigated the critical role of MIG6 in vascular permeability. MIG6 deficiency promotes VEGFA‐induced vascular permeability via activation of PLCγ1‐Ca2+‐eNOS signaling and perturbation of the balance in RAC1/RHOA activation, resulting in endothelial barrier disruption.
Liying Xing +12 more
wiley +1 more source
Cardiovascular Therapeutics, Volume 2023, Issue 1, 2023., 2023 The current study was designed to determine pulegone’s antihypertensive and vasoprotective activity in L‐NAME‐induced hypertensive rats. Firstly, the hypotensive dose‐response relationship of pulegone was evaluated in normotensive anesthetized rats using the invasive method. Secondly, the mechanism involved in hypotensive activity was determined in the
Muryam Abdul Razzaq +9 more
wiley +1 more source
The effect of L-arginine and L-NAME on myocardial capillary density in normal rats
Advanced Biomedical Research, 2013 Background: This study evaluated the effect of L-arginine (Nitric Oxide (NO) precursor) and L-NG-Nitroarginine Methyl Ester (L-NAME) (NO synthase inhibitor) on myocardial capillary density in normal rats.
Majid Khazaei +7 more
doaj +1 more source
Mineralocorticoid receptor in cardiovascular diseases—Clinical trials and mechanistic insights
British Journal of Pharmacology, Volume 179, Issue 13, Page 3119-3134, July 2022., 2022 Aldosterone binds to the mineralocorticoid receptor (NR3C2), a transcription factor of the nuclear receptor family, present in the kidney and in various other non‐epithelial cells including the heart and the vasculature. Indeed, extra‐renal pathophysiological effects of this hormone have been characterized, extending its actions to the cardiovascular ...
Johann Bauersachs +1 more
wiley +1 more source
Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells [PDF]
, 2014 The anti-human immunodeficiency virus (HIV) drug efavirenz (EFV) alters mitochondrial function in cultured neurons and glial cells. Nitric oxide (NO) is a mediator of mitochondrial dysfunction associated with HIV central nervous system symptoms.
Alegre, Fernando +5 more
core +1 more source
British Journal of Pharmacology, Volume 179, Issue 4, Page 659-676, February 2022., 2022 Cardiovascular outcome trials revealed cardiovascular benefits for type 2 diabetes mellitus patients when treated with long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonists. In the last decade, major advances were made characterising the physiological effects of GLP‐1 and its action on numerous targets including brain, liver, kidney, heart and ...
Johanna Helmstädter +5 more
wiley +1 more source
7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures [PDF]
, 1995 7-Nitro indazole (25–100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system
Dzoljic, E. (Eleonora) +2 more
core +1 more source
Frontiers in Neuroscience, 2022 Mid-life hypertension is a major risk factor for developing dementia later in life. While anti-hypertensive drugs restore normotension, dementia risk remains above baseline suggesting that brain damage sustained during transient hypertension is ...
Aaron Y. Lai +7 more
doaj +1 more source