Results 91 to 100 of about 36,040 (208)

Supplemental_Material_for_NMNAT_Screening_Assay__by_Haubrich_et_al – Supplemental material for Development of a Bioluminescent High-Throughput Screening Assay for Nicotinamide Mononucleotide Adenylyltransferase (NMNAT)

, 2019
Supplemental material, Supplemental_Material_for_NMNAT_Screening_Assay__by_Haubrich_et_al for Development of a Bioluminescent High-Throughput Screening Assay for Nicotinamide Mononucleotide Adenylyltransferase (NMNAT) by Brad A.
Brad A. Haubrich (7467089), Chakk Ramesha (2551129), David C. Swinney (793616)   +2 more
core   +1 more source

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration [PDF]

, 2015
NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), for their ...
Janeckova, L, Vargas, M. E, Meng, W, L A Worrell, ORSOMANDO, Giuseppe, G Orsomando, L Janeckova, A Sagasti, Pucciarelli, S, Sagasti, A, MORI, VALERIO, Vargas, ME, Worrell, L. A, L Conforti, Di Stefano, M, Webster, JRM, Magni, G, M P Coleman, Worrell, LA, S Pucciarelli, PUCCIARELLI, Stefania, Carpi, F. M, MAGNI, GIULIO, A Loreto, I Nascimento-Ferreira, J Tickle, V Mori, Ribchester, R. R, Tickle, J, Orsomando, G, Brown, R, Conforti, L, Webster, J. R. M, Conforti, L., R R Ribchester, W Meng, Nascimento-Ferreira, I, M E Vargas, J Gilley, Marangoni, M, M Marangoni, F M Carpi, Carpi, FM, Coleman, MP, Mori, V, Gilley, J, Ribchester, RR, M Di Stefano, Nascimento Ferreira, I, Rossi, F, J Patrick, Loreto, A, Patrick, J, F Rossi, G Magni, R Brown, J R M Webster, Coleman, M. P   +57 more
core   +2 more sources

Streamlining Design, Engineering, and Applications of Nicotinamide Riboside Kinase for Sustainable Biosynthesis of Nicotinamide Mononucleotide in Flow

, 2023
The market demand for β-nicotinamide mononucleotide (NMN), an antiaging health product, is rapidly expanding. Consequently, there is an urgent requirement for an environment-friendly and economical approach to synthesize NMN.
Ke-Xin Li (12459120), Qian Guo (107009), Feng Cheng, Ya-Ping Xue, Huan Li (120482), Qi Shen, Yu-Guo Zheng, Ya-Ping Xue (427998), Feng Cheng (124653), Yu-Guo Zheng (427999), Xiao-Hu Wu, Huan Li, Ke-Xin Li, Qian Guo, Qi Shen (166827), Xiao-Hu Wu (17109342)   +15 more
core   +1 more source

β-Nicotinamide mononucleotide protects against hypervirulent <i>Klebsiella pneumoniae</i> bloodstream infection and liver injury. [PDF]

mSphere
In clinical practice, hypervirulent Klebsiella pneumoniae (hvKP) often causes bloodstream infections (BSI) and liver abscesses; however, the mechanism of hvKP-induced liver abscess formation remains unclear.
Cao Z, Meng B, Chen J, Ge R, Liu Y, Li J.   +5 more
europepmc   +2 more sources

The Role of Nicotinamide Mononucleotide Supplementation in Psoriasis Treatment

Antioxidants
Psoriasis is one of several chronic inflammatory skin diseases with a high rate of recurrence, and its pathogenesis remains unclear. Nicotinamide mononucleotide (NMN), as an important precursor of nicotinamide adenine dinucleotide (NAD+), has been reported to be a promising agent in treating various diseases, its positive effects including those ...
Zhengyi Zhang, Baochen Cheng, Wenqian Du, Mengqi Zeng, Ke He, Tingyi Yin, Sen Shang, Tian Su, Dan Han, Xinyi Gan, Ziyang Wang, Meng Liu, Min Wang, Jiankang Liu, Yan Zheng   +14 more
openaire   +3 more sources

Nicotinamide adenine dinucleotide is transported into mammalian mitochondria

eLife, 2018
Mitochondrial NAD levels influence fuel selection, circadian rhythms, and cell survival under stress. It has alternately been argued that NAD in mammalian mitochondria arises from import of cytosolic nicotinamide (NAM), nicotinamide mononucleotide (NMN),
Antonio Davila, Ling Liu, Karthikeyani Chellappa, Philip Redpath, Eiko Nakamaru-Ogiso, Lauren M Paolella, Zhigang Zhang, Marie E Migaud, Joshua D Rabinowitz, Joseph A Baur   +9 more
doaj   +1 more source

CD38 mediates nicotinamide mononucleotide base exchange to yield nicotinic acid mononucleotide

Nicotinamide mononucleotide (NMN) is a widely investigated metabolic precursor to the prominent enzyme cofactor NAD+, where it is assumed that delivery of this compound results in its direct incorporation into NAD+ via the canonical salvage/recycling ...
Wu, LE ; https://orcid.org/, Turner, N ; https://orcid.org/, Madawala, R, Hancock, SE ; https://orcid.org/, Quek, LE, Banks, JL   +5 more
core   +1 more source

Identification and functional evaluation of Leishmania braziliensis Nicotinamide Mononucleotide Adenylyltransferase

, 2015
The progressive increase in Leishmania resistance to current control approaches prompts the need to develop therapeutic strategies based on comprehensive knowledge of the parasite’s biology.
Contreras, L., Ramírez, M., Neme, R.
core   +1 more source

An Updated Review on the Mechanisms, Pre‐Clinical and Clinical Comparisons of Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR)

Food Frontiers
The study of nicotinamide adenine dinucleotide (NAD+) biology has gained popularity recently. Research discovered that two NAD+ biosynthesis intermediates, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), are biosynthetic precursors of ...
Xu Yang, Anni Lu, Xiao Guan, Tianlei Ying, Jingrong Pan, Mingqian Tan, Jun Lu   +6 more
doaj   +1 more source

Nicotinamide Mononucleotide Supplementation Alleviates Doxorubicin-Induced Multi-Organ Fibrosis

Doxorubicin (DOX) is a potent chemotherapeutic agent known for its multi-organ toxicity, especially in the heart, which limits its clinical application. The toxic side effects of DOX, including DNA damage, oxidative stress, mitochondrial dysfunction and ...
Zhiliang Xi, Yuanlong Ge, Shenglong Yang, Wenjing Wei, Anhua Xu, Zhenyu Ju, Fei Wen, Shu Wu   +7 more
core   +1 more source