Results 81 to 90 of about 36,040 (208)

P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
P7C3 activates NAMPT, the rate‐limiting enzyme in the NAD+ salvage pathway, elevating NAD+ levels in neurons. This engages SIRT1‐dependent nuclear signaling and SIRT3‐dependent mitochondrial regulation, enhancing mitochondrial quality control, reducing oxidative stress, and promoting neuronal survival.
Yajing Chen, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Zengyan Zhu, Mei Wang, Chao Gu   +7 more
wiley   +1 more source

Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal Brain

, 2022
As a redox-sensitive coenzyme, nicotinamide adenine dinucleotide (NAD+) plays a central role in cellular energy metabolism and homeostasis. Low NAD+ levels are linked to multiple disease states, including age-related diseases, such as metabolic and ...
Ramanathan, Chidambaram, Zhang, Yufeng, Drake H. Williams, Bloomer, Richard J., Paul S. Simone, Lackie, Thomas, Chidambaram Ramanathan, Simone, Paul S., Williams, Drake H., Yufeng Zhang, Thomas Lackie, Richard J. Bloomer   +11 more
core   +1 more source

Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men

Endocrine Journal
Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD+), a regulator of many biological processes, declines in
Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh   +13 more
doaj   +1 more source

A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects

Translational Medicine of Aging, 2020
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose supplementation of nicotinamide, a form of ...
Takashi K. Ito, Tomohito Sato, Akio Hakamata, Yuki Onoda, Shumpei Sato, Fumiyoshi Yamazaki, Makoto Horikawa, Yutaka Takahashi, Takuya Kitamoto, Masako Suzuki, Shinya Uchida, Keiichi Odagiri, Mitsutoshi Setou   +12 more
doaj   +1 more source

Exogenous nicotinamide mononucleotide, NAMPT-catalyzed reaction end product, reverts the inhibitory effects of APO866.

, 2013
Mouse PEC were incubated in the presence or absence of 200 nM APO866 and 10 mM nicotinamide mononucleotide (NMN). Cells were further stimulated with LPS and intracellular NAD levels and TNFα and IL-6 secretion were determined.
Frédéric Van Gool (198333), Thibaut De Smedt (76288), Massimo Nobile (377676), Nathalie Busso (8780), Alexander So (8781), Mahir Karababa (377675), Oberdan Leo (33376), Mara Galli (377678), Aline Rolaz (377677)   +8 more
core   +1 more source

SLC29A1 and SLC29A2 are human nicotinamide cell membrane transporters

Nature Communications
Nicotinamide (NAM), a main precursor of NAD+, is essential for cellular fuel respiration, energy production, and other cellular processes. Transporters for other precursors of NAD+ such as nicotinic acid and nicotinamide mononucleotide (NMN) have been ...
Mingyang Chen, Luexiang Yuan, Binxin Chen, Hui Chang, Jun Luo, Hengbin Zhang, Zhongjian Chen, Jiao Kong, Yaodong Yi, Mengru Bai, Minlei Dong, Hui Zhou, Huidi Jiang   +12 more
doaj   +1 more source

CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves [PDF]

, 2018
NAD+ and cognitive hypersensitivity during aging Cognitive dysfunction is one of the most concerning outcomes in global population aging. However, the mechanisms of cognitive impairment during aging remain elusive.
Johnson, Sean, David F. Wozniak, Imai, S., S. Imai, Sean Johnson, Wozniak, David F   +5 more
core   +1 more source

Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging

Aging and disease
Nicotinamide adenine dinucleotide (NAD+) has recently attracted much attention due to its role in aging and lifespan extension. NAD+ directly and indirectly affects many cellular processes, including metabolic pathways, DNA repair, and immune cell activities. These mechanisms are critical for maintaining cellular homeostasis.
Rahman, Sajid Ur, Qadeer, Abdul, Wu, Ziyun   +2 more
openaire   +2 more sources

Nicotinamide Mononucleotide From Bacillus licheniformis MW301654 Unravels the Nematicidal Property Against Meloidogyne incognita

Ashraf S, Nayana RUK, Nakkeeran S, et al. Nicotinamide Mononucleotide From <i>Bacillus licheniformis</i> MW301654 Unravels the Nematicidal Property Against <i>Meloidogyne incognita</i>. Journal of Basic Microbiology.
Nayana, R. U. Krishna, Fatimah, Nusrat, Raish, Mohammad, Ashraf, Suhail, Nallusamy, Saranya, Jardan, Yousef A. Bin, Nakkeeran, Sevugapperumal   +6 more
core   +1 more source

The function of nicotinamide phosphoribosyl transferase (NAMPT) and its role in diseases

Frontiers in Molecular Biosciences
Nicotinamide phosphoribosyl transferase (NAMPT) is a rate-limiting enzyme in the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway, and plays a vital role in the regulation of cell metabolic activity, reprogramming, aging and apoptosis ...
Aihong Peng, Junqin Li, Jianxiao Xing, Yuanjun Yao, Xuping Niu, Kaiming Zhang   +5 more
doaj   +1 more source