Results 61 to 70 of about 36,040 (208)

Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy

, 2021
BACKGROUND: The activation of NAD(+)-dependent deacetylase, Sirt1, by the administration of nicotinamide mononucleotide (NMN) ameliorates various aging-related diseases.
Yasuda, Itaru, Hirobumi Tokuyama, Shu Wakino, Ei Kusahana, Takashi Ono, Hiroshi Itoh, Kusahana, Ei, Takeshi Kanda, Muraoka, Hirokazu, Tokuyama, Hirobumi, Kanda, Takeshi, Yusuke Sakamaki, Itoh, Hiroshi, Takahisa Kawaguchi, Sakamaki, Yusuke, Wakino, Shu, Ono, Takashi, Kazuhiro Hasegawa, Hirokazu Muraoka, Kawaguchi, Takahisa, Itaru Yasuda, Hasegawa, Kazuhiro   +21 more
core   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Nicotinamide Mononucleotide Administration Triggers Macrophages Reprogramming and Alleviates Inflammation During Sepsis Induced by Experimental Peritonitis

Frontiers in Molecular Biosciences, 2022
Peritonitis and subsequent sepsis lead to high morbidity and mortality in response to uncontrolled systemic inflammation primarily mediated by macrophages.
Cécile Cros, Marielle Margier, Hélène Cannelle, Julie Charmetant, Nicolas Hulo, Laurent Laganier, Laurent Laganier, Alessia Grozio, Matthias Canault, Matthias Canault   +9 more
doaj   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Can we manipulate the ovary’s own metabolism to protect it from chemotherapy-induced damage?

EMBO Molecular Medicine
Some chemotherapy treatments induce female infertility through accelerated ovarian ageing, including due to nicotinamide adenine dinucleotide (NAD) depletion.
Adomas Liugaila, Agnes Stefansdottir, Norah Spears   +2 more
doaj   +1 more source

Metabolic remodelling in anthracycline cardiotoxicity: mechanisms and therapeutic insights

British Journal of Pharmacology, EarlyView.
Cardiac metabolic remodelling in anthracycline‐induced cardiomyopathy and metabolically oriented cardioprotective strategies. Schematic representation of substrate utilization, mitochondrial bioenergetic function and metabolic flexibility in the healthy heart, in anthracycline‐induced cardiomyopathy and under potential cardioprotective interventions ...
Giulia Guerra, Francesco Niro, Marco Mergiotti, Giovanni Gavatorta, Emilio Hirsch, Alessandra Ghigo   +5 more
wiley   +1 more source

Nicotinamide-mononucleotide adenylyltransferases from yeast and other microorganisms

, 1997
The enzyme nicotinamide–mononucleotide adenylyltransferase plays a key role in pyridine nucleotide turnover, being involved in both de novo and salvage synthesis of nicotinamide adenine dinucleotide (NAD).
AMICI, Adolfo, Monica Emanuelli, Paolo Natalini, RUGGIERI, Silverio, Nadia Raffaelli, Silverio Ruggieri, Emanuelli, Monica, NATALINI, Paolo, Adolfo Amici, NATALINI, PAOLA, Giulio Magni, RAFFAELLI, Nadia, Magni, Giulio   +12 more
core   +1 more source

NAD+ biosynthesis, aging, and disease [version 1; referees: 2 approved]

F1000Research, 2018
Nicotinamide adenine dinucleotide (NAD+) biosynthesis and its regulation have recently been attracting markedly increasing interest. Aging is marked by a systemic decrease in NAD+ across multiple tissues.
Sean Johnson, Shin–ichiro Imai
doaj   +1 more source

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

The FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels, Michael K. F. Mohr, Phillip Nußbaum, Marie Joest, Bianca Wassmer, Laurent Rasquin, Sonja‐Verena Albers, Jennifer N. Andexer   +7 more
wiley   +1 more source