Results 51 to 60 of about 36,040 (208)

Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot

, 2013
Nicotinamide mononucleotide adenylyltransferase (NMNAT) is shown to be a synapse maintenance factor that protects the active zone structure by interacting with the active zone protein Bruchpilot and shielding it from activity-induced degradation in ...
Yousuf O Ali, Ali, Yousuf O, Zang, Shaoyun, Ruan, Kai, Kai Ruan, Zhai, R Grace, R Grace Zhai, Shaoyun Zang   +7 more
core   +1 more source

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells [PDF]

, 2017
Objective: Augmenting nicotinamide adenine dinucleotide (NAD+) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) appear
Migaud, Marie E., Lucy A. Oakey, Rachel S. Fletcher, Carles Canto, Brenner, C, Migaud, ME, Oakey, Lucy A, Gabriella Da Silva Xavier, Joanna Ratajczak, Craig L. Doig, Philp, A, Lavery, Gareth G., Canto, Carles, Da Silva Xavier, Gabriella; id_orcid, Canto, C, Garten, Antje, Oakey, Lucy A., Elhassan, Yasir S., Lavery, GG, Yasir S. Elhassan, Elhassan, Yasir S; id_orcid, Elhassan, YS, Ratajczak, Joanna, Callingham, Rebecca, Fletcher, RS, Redpath, P, Antje Garten, Garten, A, Xavier, Gabriella Da Silva, Da Silva Xavier, G, Oakey, LA, Doig, Craig L., Fletcher, Rachel S., Andrew Philp, Gareth G. Lavery, Migaud, Marie E, Brenner, Charles, Charles Brenner, Marie E. Migaud, Ratajczak, J, Callingham, R, Rebecca Callingham, Philp, Andrew, Doig, CL, Doig, Craig L, Redpath, Philip, Lavery, Gareth G, Philip Redpath, Fletcher, Rachel S   +48 more
core   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Crystallization and preliminary X-ray analysis of human nicotinamide mononucleotide adenylyltransferase (NMNAT)

, 2002
Nicotinamide mononucleotide adenylyltransferase catalyses the final step in the synthesis of nicotinamide-adenine dinucleotide (NAD+) by transferring the adenylyl moiety of ATP to nicotinamide mononucleotide (NMN) with the release of pyrophosphate.
Heinemann, U., Muller, Y.A., Werner, E., Ziegler, M., Lerner, F., Schweiger, M.   +5 more
core   +1 more source

The Vitamin Nicotinamide: Translating Nutrition into Clinical Care

Molecules, 2009
Nicotinamide, the amide form of vitamin B3 (niacin), is changed to its mononucleotide compound with the enzyme nicotinic acide/nicotinamide adenylyltransferase, and participates in the cellular energy metabolism that directly impacts normal physiology ...
Zhao Zhong Chong, Jinling Hou, Yan Chen Shang, Kenneth Maiese   +3 more
doaj   +1 more source

Metabolic engineering of Escherichia coli for biosynthesis of β‐nicotinamide mononucleotide from nicotinamide

Microbial Biotechnology, 2021
Summary The β‐nicotinamide mononucleotide (NMN) is a key intermediate of an essential coenzyme for cellular redox reactions, NAD. Administration of NMN is reported to improve various symptoms, such as diabetes and age‐related physiological decline. Thus,
Yang Liu, Montri Yasawong, Bo Yu
doaj   +1 more source

Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis

Frontiers in Public Health, 2023
ObjectiveAging is associated with decreased nicotinamide adenine dinucleotide (NAD) levels, which in turn cause dysfunctional mitochondria and indirectly affect a myriad of diseases. Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) serves as
Xu Sun, Lide Su, Lide Su, Te Bu, Te Bu, Yang Zhang   +5 more
doaj   +1 more source

Nicotinamide mononucleotide adenylyltransferase displays alternate binding modes for nicotinamide nucleotides [PDF]

Acta Crystallographica Section D Biological Crystallography, 2015
Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the biosynthesis of NAD+and NaAD+. The crystal structure of NMNAT fromMethanobacterium thermoautotrophicumcomplexed with NAD+and SO42−revealed the active-site residues involved in binding and catalysis.
Roland, Pfoh, Emil F, Pai, Vivian, Saridakis   +2 more
openaire   +2 more sources

Functional characterisation of three human nicotinamide mononucleotide adenylyltransferases [PDF]

, 2008
Nicotinamide adenine dinucleotide, NAD, is an essential redox factor in many, primarily catabolic, hydrogen transfer reactions. While the redox reactions are not accompanied by a net loss of the pyridine nucleotides, NAD+ is actively degraded in a ...
Lau, Corinna
core   +1 more source

Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing

Nature Communications, 2022
Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in ...
Xiao-Ru Ma, Xudong Zhu, Yujie Xiao, Hui-Min Gu, Shuang-Shuang Zheng, Liang Li, Fan Wang, Zhao-Jun Dong, Di-Xian Wang, Yang Wu, Chenyu Yang, Wenhong Jiang, Ke Yao, Yue Yin, Yang Zhang, Chao Peng, Lixia Gao, Zhuoxian Meng, Zeping Hu, Chong Liu, Li Li, Hou-Zao Chen, Yousheng Shu, Zhenyu Ju, Jing-Wei Zhao   +24 more
doaj   +1 more source