Results 41 to 50 of about 7,313 (206)

Melatonin and Nitrones As Potential Therapeutic Agents for Stroke

Frontiers in Aging Neuroscience, 2016
Stroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved.
Alejandro Romero, Eva Ramos, Paloma Patiño, Maria J. Oset-Gasque, Francisco López-Muñoz, Francisco López-Muñoz, José Marco-Contelles, María I. Ayuso, Alberto Alcázar   +8 more
doaj   +1 more source

Synthesis and Evaluation of Antimicrobial Activity of Nitrones from Derivatives of Aryl-Substituted Dihydroisoquinoline

Journal of Chemistry, 2015
This paper describes the synthesis of a series of dihydroisoquinoline nitrones by isomerization of the corresponding oxaziridines. Nitrones 4a–c were obtained in excellent yields and high purity by a simple and effective method from the isomerization of ...
Mouna Bouzid, Raed Abdennabi, Mohamed Damak, Majed Kammoun   +3 more
doaj   +1 more source

Molecular Networks in Dynamic Multilevel Systems [PDF]

, 2018
Dynamic multilevel systems can be assembled from molecular building blocks through two or more reversible reactions that form covalent bonds. Molecular networks of dynamic multilevel systems can exhibit different connectivities between nodes.
Cabezudo, Ignacio, Escalante, Andrea Marta, Furlan, Ricardo Luis Eugenio, Martinez Amezaga, Maitena, Orrillo, Alfredo Gastón   +4 more
core   +1 more source

(4+2)-cycloaddition of nitroalkenes with ynamines; formation of a 4H-1,2-oxazine 2-oxide derivative [PDF]

, 1980
The formation of a thermally unstable (4+2)-cycloadduct, a 4H-1,2-oxazine 2-oxide derivative ( ), from the reaction of 1-nitrocyclopentene with 1-phenyl-2-(1-pyrrolidinyl)acetylene has been proven by the structure elucidation of isoxazole derivative ...
Pennings, M.L.M., Reinhoudt, D.N.
core   +2 more sources

A Straightforward Route to Enantiopure Pyrrolizidines and Indolizidines by Cycloaddition to Pyrroline N-Oxides Derived from the Chiral Pool

Molecules, 1998
Enantiomerically pure, five membered cyclic nitrones, easily obtained in large amounts from protected hydroxyacids and aminoacids such as D- and L-tartaric, L-malic, and L-aspartic acids, give cycloaddition reactions with a good diastereocontrol.
Alberto Brandi, Valentina Fedi, Franca M. Cordero, Stefano Cicchi, Andrea Goti   +4 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of N-[(Z)-(2-hydroxyphenyl)methylidene]aniline N-oxide

Acta Crystallographica Section E: Crystallographic Communications, 2021
The conformation of the title compound, C13H11NO2, is partially determined by a strong, intramolecular O—H...O hydrogen bond. The crystal packing consists of strongly corrugated layers parallel to the ac plane and associated through C—H...π(ring ...
Shaaban K. Mohamed, Awad I. Said, Joel T. Mague, Moustafa F. Aly, Mehmet Akkurt, Sahar M. I. Elgarhy   +5 more
doaj   +1 more source

Easy Access to Configurationally Controlled C-Glycofuranoside-Based Building Blocks by Means of Formyl C-Glycofuranosides [PDF]

, 2010
A general approach to enantiopure C-glycofuranoside-based hybridα/β-amino acids and nitrones, among other valuable building blocks, has been established via formyl C-glycofuranosides, easily available from hexose-derived equatorial-2-OH-glycopyranosides ...
Borrachero Moya, Pastora, Cabrera Escribano, Francisca, Caner, Joaquín, Farrás, Jaume, Gómez Guillén, Manuel, Vera-Ayoso, Yolanda   +5 more
core   +1 more source

Probing the limits of selectivity in a recognition-mediated reaction network embedded within a dynamic covalent library [PDF]

, 2016
This work was supported by the award of a Postgraduate Studentship from EPSRC (EP/K503162/1) to TK.Two recognition-mediated reaction processes operating through a reactive binary complex drive resolution of a 24-component dynamic covalent library ...
Angelin, Angelin, Ashkenasy, Barboiu, Belowich, Bennes, Besenius, Besenius, Brisig, Bugaut, Campbell, Carnall, Cheeseman, Chung, Corbett, Corbett, del Amo, Eelkema, Epstein, Furlan, Gareiss, Giuseppone, Hamieh, Herrmann, Hu, Hunt, Jin, Kindermann, Lehn, Lehn, Li, Ludlow, Moulin, Nitschke, Noorduin, Peyralans, Ramström, Rowan, Ruiz-Mirazo, Sadownik, Sadownik, Sakulsombat, Salles, Sarma, Sievers, Sijbren, Stankiewicz, Strogatz, Turega, Vicsek, Vidonne, Vongvilai, Vongvilai, Vongvilai, Whitesides, Xu, Zhang, Zhang   +57 more
core   +1 more source

Synthesis of a New β-Galactosidase Inhibitor Displaying Pharmacological Chaperone Properties for GM1 Gangliosidosis

Molecules, 2022
GM1 gangliosidosis is a rare lysosomal disease caused by the deficiency of the enzyme β-galactosidase (β-Gal; GLB1; E.C. 3.2.1.23), responsible for the hydrolysis of terminal β-galactosyl residues from GM1 ganglioside, glycoproteins, and ...
Francesca Clemente, Macarena Martínez-Bailén, Camilla Matassini, Amelia Morrone, Silvia Falliano, Anna Caciotti, Paolo Paoli, Andrea Goti, Francesca Cardona   +8 more
doaj   +1 more source

Cycloaddition of Benzyne with Alkoxy-Substituted Pyrroline-N-oxides­: Unexpected Rearrangement to an N-Phenylpyrrole

SynOpen, 2018
Reaction of enantiopure 3,4-dialkoxy-pyrroline N-oxides with benzyne affords the expected tetrahydrobenzo[d]pyrrolo[1,2-b]isoxazoles along with an unexpected 2,3-disubstitued-N-phenyl-pyrrole derived from an unprecedented rearrangement of the adduct of ...
Franca M. Cordero, Bhushan B. Khairnar, Anna Ranzenigo, Alberto Brandi   +3 more
doaj   +1 more source