Results 1 to 10 of about 582,834 (142)

Role of NK cells in immune escape in patients with classical paroxysmal nocturnal haemoglobinuria [PDF]

Clinical and Translational Medicine
Background Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal haematopoietic stem cell disorder. Immune escape is crucial in PNH, and our previous studies revealed that natural killer (NK) cells potential participate in the immune escape of
Chaomeng Wang, Yan Yang, Wei Wang, Liyan Li, Mengting Che, Yingying Chen, Honglei Wang, Zhaoyun Liu, Lijuan Li, Hui Liu, Rong Fu   +10 more
doaj   +2 more sources

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

Immuno, 2021
NK cells are lymphocytes involved in the innate and adaptative immune response. These cells are located in peripheral blood and tissues with ample functions, from immune vigilant to tolerogenic reactions.
Jenny Valentina Garmendia, Juan Bautista De Sanctis   +1 more
doaj   +1 more source

Optimizing NK Cell-Based Immunotherapy in Myeloid Leukemia: Abrogating an Immunosuppressive Microenvironment

Frontiers in Immunology, 2021
Natural killer (NK) cells are prominent cytotoxic and cytokine-producing components of the innate immune system representing crucial effector cells in cancer immunotherapy.
Natasha Mupeta Kaweme, Fuling Zhou
doaj   +1 more source

g-NK cells from umbilical cord blood are phenotypically and functionally different than g-NK cells from peripheral blood

OncoImmunology, 2023
FcRγ-deficient natural killer (NK) cells, designated as g-NK cells, exhibit enhanced antibody-dependent cellular cytotoxicity (ADCC) capacity and increased IFN-γ and TNF-α production, rendering them promising for antiviral and antitumor responses.
Fei Gao, Mauricio Campos Mora, Michael Constantinides, Loïs Coenon, Caroline Multrier, Loïc Vaillant, Tianxiang Zhang, Martin Villalba   +7 more
doaj   +1 more source

The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56bright NK cells

Frontiers in Immunology, 2023
The crosstalk between NK cells and their surrounding environment is enabled through activating and inhibitory receptors, which tightly control NK cell activity.
Annerose E. Ziegler, Annerose E. Ziegler, Pia Fittje, Luisa M. Müller, Annika E. Ahrenstorf, Kerri Hagemann, Sven H. Hagen, Leonard U. Hess, Annika Niehrs, Tobias Poch, Gevitha Ravichandran, Sebastian M. Löbl, Benedetta Padoan, Sébastien Brias, Sébastien Brias, Jana Hennesen, Myrtille Richard, Laura Richert, Sven Peine, Karl J. Oldhafer, Lutz Fischer, Christoph Schramm, Christoph Schramm, Glòria Martrus, Madeleine J. Bunders, Madeleine J. Bunders, Marcus Altfeld, Sebastian Lunemann   +27 more
doaj   +1 more source

Natural killer cells-related immune traits and amyotrophic lateral sclerosis: A Mendelian randomization study

Frontiers in Neuroscience, 2022
BackgroundObservational studies have suggested that peripheral immune disorders are associated with amyotrophic lateral sclerosis (ALS). Previous studies predominantly focused on changes in adaptive immunity.
Zhenxiang Gong, Yang Liu, Fengfei Ding, Li Ba, Min Zhang   +4 more
doaj   +1 more source

Umbilical cord blood as a promising source of NK cells for immunotherapy

Медицинская иммунология, 2023
Currently, a large number of studies on genetic modification of cord blood NK cells (UCB-NK) are carried out at both clinical and preclinical levels. Immunotherapy based on UCB-NK cells has great potential for antitumor therapy.
R. A. Velichinskii, J. D. Vavilova, A. A. Boyko, O. A. Shustova, A. I. Palamarchuk, G. M. Yusubalieva, O. N. Kucherova, M. A. Streltsova, E. I. Kovalenko   +8 more
doaj   +1 more source

'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection. [PDF]

, 2010
Natural killer (NK) cells expressing inhibitory receptors that bind to self major histocompatibility complex (MHC) class I are 'licensed', or rendered functionally more responsive to stimulation, whereas 'unlicensed' NK cells lacking receptors for self ...
Lanier, Lewis L, Murphy, William J, Orr, Mark T   +2 more
core   +3 more sources

Human natural killer cell committed thymocytes and their relation to the T cell lineage. [PDF]

, 1993
Recent studies have demonstrated that mature natural killer (NK) cells can be grown from human triple negative (TN; CD3-, CD4-, CD8-) thymocytes, suggesting that a common NK/T cell precursor exists within the thymus that can give rise to both NK cells ...
Lanier, LL, Phillips, JH, Spits, H, Sánchez, MJ   +3 more
core   +1 more source

NK cells are not required for spontaneous autoimmune diabetes in NOD mice. [PDF]

PLoS ONE, 2012
NK cells have been shown to either promote or protect from autoimmune diseases. Several studies have examined the role of receptors preferentially expressed by NK cells in the spontaneous disease of NOD mice or the direct role of NK cells in acute ...
Joshua N Beilke, Craig T Meagher, Karoline Hosiawa, Marine Champsaur, Jeffrey A Bluestone, Lewis L Lanier   +5 more
doaj   +1 more source