Results 11 to 20 of about 262,765 (147)
Frontiers in Immunology, 2017 Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus limiting the antitumor/infection potential of NK cells.
Jiacheng Bi, Zhigang Tian, Zhigang Tian
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The Journal of Immunology, 2007 Abstract In this review, we overview the main features and functions of NK cells, focusing on their role in cell-mediated immune response to tumor cells. In parallel, we discuss the information available in the field of NK cell receptors and offer a wide general overview of functional aspects of cell targeting and killing, focusing on ...
Zamai L +7 more
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Journal of Leukocyte Biology, 2019 AbstractNatural Killer (NK) cells are important antiviral and anticancer effector cells. They have excellent potential for immunotherapy although impaired functions during cancer limit their effectiveness. The discovery that cellular metabolism can impact on and regulate immune functions has led to an explosion of articles in this new area of ...
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Frontiers in Immunology, 2023 Natural killer (NK) cells are cellular components of the innate immune system that can recognize and suppress the proliferation of cancer cells. NK cells can eliminate cancer cells through direct lysis, by secreting perforin and granzymes, or through ...
Massimo Fantini +2 more
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Tumor-priming converts NK cells to memory-like NK cells
OncoImmunology, 2017 Fascinating earlier evidence suggests an intrinsic capacity of human natural killer (NK) cells to acquire adaptive immune features in the context of cytomegalovirus (CMV) infection or pro-inflammatory cytokine stimulation.
Marina Pal +10 more
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Leukemia, 2021 AbstractNatural killer/T-cell lymphoma (NKTL) is a sub-type of Epstein–Barr virus (EBV)-related non-Hodgkin lymphomas common in Asia and Latin America but rare elsewhere. Its pathogenesis is complex and incompletely understood. Lymphoma cells are transformed from NK- or T-cells, sometimes both.
Hua Wang +3 more
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NK-B cell cross talk induces CXCR5 expression on natural killer cells
iScience, 2021 Summary: B cell follicles (BCFs) in lymph nodes (LNs) are generally exempt of CD8+ T and NK cells. African green monkeys (AGMs), a natural host of simian immunodeficiency virus (SIV), display NK cell-mediated viral control in BCF.
Philippe Rascle +10 more
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Nature Reviews Immunology, 2017 My interest in uterine natural killer (NK) cells began in the early 1990s, when I and others described the striking accumulation of NK cells in the uterine mucosa during the establishment of the placenta. Whilst working as a reproductive pathologist, I had become intrigued by pre-eclampsia, a mysterious syndrome that only occurs in pregnant women.
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Journal of Neuroinflammation, 2019 Background Recent studies have demonstrated that natural killer (NK) cells can modulate other immune components and are involved in the development or progression of several autoimmune diseases. However, the roles and mechanisms of NK cells in regulating
Chun-Lin Yang +9 more
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Frontiers in Immunology, 2017 Clinical studies with adoptive immunotherapy using allogeneic natural killer (NK) cells showed feasibility, but also limitation regarding the transfused absolute cell numbers.
María Delso-Vallejo +3 more
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