Results 21 to 30 of about 262,765 (147)
Phenotypic and Functional Plasticity of CXCR6+ Peripheral Blood NK Cells
Frontiers in Immunology, 2022 Human NK cells are comprised of phenotypic subsets, whose potentially unique functions remain largely unexplored. C-X-C-motif-chemokine-receptor-6 (CXCR6)+ NK cells have been identified as phenotypically immature tissue-resident NK cells in mice and ...
Laura S. Angelo +6 more
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Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects
Engineering, 2019 Natural killer (NK) cells are key innate immune cells that provide the first line of defense against viral infection and cancer. Although NK cells can discriminate between “self” and “non-self,” recognize abnormal cells, and eliminate transformed cells ...
Yuan Hu, Zhigang Tian, Cai Zhang
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NK cell inflammation in the clinical outcome of colorectal carcinoma
Frontiers in Medicine, 2015 The ability of natural killer (NK) cells to provide protection against myeloid leukemia has been demonstrated in clinical settings. However, whether NK cells play a role in the clinical course of solid tumors is debated.
Andrea eCoppola +8 more
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Flow cytometry analysis of cytotoxic cells in patients with chronic hepatitis C
Журнал инфектологии, 2014 In patients with chronic hepatitis C study the content of different populations of cytotoxic lymphocytes by flow cytometry. There was a significant decrease in functional capacity of NK -cells in determining the expression of CD 107 a picture of the ...
M. S. Selkova
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Osteoclast-expanded super-charged NK-cells preferentially select and expand CD8+ T cells
Scientific Reports, 2020 Osteoclasts (OCs) and much less dendritic cells (DCs) induce significant expansion and functional activation of NK cells, and furthermore, the OC-expanded NK cells preferentially increase the expansion and activation of CD8+ T cells by targeting CD4+ T ...
Kawaljit Kaur +4 more
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High Metabolic Function and Resilience of NKG2A-Educated NK Cells
Frontiers in Immunology, 2020 Natural killer (NK) cells are an important component of the innate immune system for the control of intracellular pathogens and cancer cells. NK cells demonstrate heterogeneous expression of inhibitory surface receptors.
Andrew J. Highton +9 more
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A four-stage model for murine natural killer cell development in vivo
Journal of Hematology & Oncology, 2022 Natural killer (NK) cells are the predominant innate lymphoid cells that mediate anti-viral and anti-tumor immunity. NK cells arise from hematopoietic stem cells in the bone marrow (BM) and undergo lineage specification and maturation.
Shoubao Ma +2 more
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Resident Peritoneal NK Cells [PDF]
The Journal of Immunology, 2011 Abstract In this study, we describe a new population of NK cells that reside in the normal, uninflamed peritoneal cavity. Phenotypically, they share some similarities with the small population of CD49b−, CD27+ immature splenic NK cells, as well as liver NK cells, but they differ in their expression of CD62L, TRAIL, and EOMES ...
Rosemary, Gonzaga +2 more
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Genes and Diseases, 2023 Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth.
Liping Wang +3 more
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NK cell-based tumor immunotherapy
Bioactive MaterialsNatural killer (NK) cells display a unique inherent ability to identify and eliminate virus-infected cells and tumor cells. They are particularly powerful for elimination of hematological cancers, and have attracted considerable interests for therapy of ...
Hao Zhang +3 more
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