Results 151 to 160 of about 22,145 (200)
Targeting the NKG2D/NKG2D-L axis in acute myeloid leukemia
Biomedicine and Pharmacotherapy, 2021 Natural killer group 2, member D (NKG2D) receptor is a crucial activating receptor in the immune recognition and eradication of abnormal cells by natural killer (NK) cells, and T lymphocytes. NKG2D can transmit activation signals and activate the immune system by recognizing the NKG2D ligands (NKG2D-L) on acute myeloid leukemia (AML) cells ...
Yanqiu He, Yingjian Zeng, Na Wan
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The Role and Regulation of the NKG2D/NKG2D Ligand System in Cancer [PDF]
Biology, 2023 The family of human NKG2D ligands (NKG2DL) consists of eight stress-induced molecules. Over 80% of human cancers express these ligands on the surface of tumour cells and/or associated stromal elements. In mice, NKG2D deficiency increases susceptibility to some types of cancer, implicating this system in immune surveillance for malignancy.
Katelyn M Spillane, John Maher
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NKG2D ligands in tumor immunity [PDF]
Oncogene, 2008 The activating receptor NKG2D (natural-killer group 2, member D) and its ligands play an important role in the NK, gammadelta(+) and CD8(+) T-cell-mediated immune response to tumors. Ligands for NKG2D are rarely detectable on the surface of healthy cells and tissues, but are frequently expressed by tumor cell lines and in tumor tissues.
Adelheid Cerwenka, Norman Nausch
exaly +3 more sources
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International Journal of Biochemistry and Cell Biology, 2009
NKG2D is an activating immunoreceptor, first recognized on NK cells but subsequently found on gammadelta T cells, CD8(+) alphabeta T cells and macrophages. In NK cells, inhibitory signals are generally dominate over activating signals. However, activating signals mediated through engagement of NKG2D by its ligands on target cells can bypass signals ...
Peyman Obeidy, Alexandra F Sharland
exaly +3 more sources
NKG2D is an activating immunoreceptor, first recognized on NK cells but subsequently found on gammadelta T cells, CD8(+) alphabeta T cells and macrophages. In NK cells, inhibitory signals are generally dominate over activating signals. However, activating signals mediated through engagement of NKG2D by its ligands on target cells can bypass signals ...
Peyman Obeidy, Alexandra F Sharland
exaly +3 more sources
NKG2D and Related Immunoreceptors
2004NK cells are crucial components of the innate immune system, capable of directly eliminating infected or tumorigenic cells and regulating down-stream adaptive immune responses. Unlike T cells, where the key recognition event driving activation is mediated by the unique T cell receptor (TCR) expressed on a given cell, NK cells express multiple ...
Roland K, Strong, Benjamin J, McFarland
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Promiscuity and the single receptor: NKG2D
Nature Reviews Immunology, 2007NKG2D (natural-killer group 2, member D) is a powerful activating receptor expressed by natural killer (NK) cells and T cells that regulates immune responses during infection, cancer and autoimmunity. NKG2D ligands comprise a diverse array of MHC-class-I-related proteins that are upregulated by cellular stress. Why is it beneficial for the host to have
Robert A, Eagle, John, Trowsdale
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Arming cytotoxic lymphocytes for cancer immunotherapy by means of the NKG2D/NKG2D-ligand system
Expert Opinion on Biological Therapy, 2020The activating NKG2D receptor plays a central role in the immune recognition and elimination of abnormal self-cells by cytotoxic lymphocytes. NKG2D binding to cell stress-inducible ligands (NKG2DL) up-regulated on cancer cells facilitates their immunorecognition. Yet tumor cells utilize various escape mechanisms to avert NKG2D-based immunosurveillance.
Mariya Lazarova +2 more
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