Nlr family, pyrin domain-containing 3 protein

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The Inflammasome NLR Family Pyrin Domain-Containing Protein 3 (NLRP3) as a Novel Therapeutic Target for Idiopathic Pulmonary Fibrosis

The American Journal of Pathology, 2022
Idiopathic pulmonary fibrosis (IPF) is a dramatic disease without cure. The US Food and Drug Administration-approved drugs, pirfenidone and nintedanib, only slow disease progression. The clinical investigation of novel therapeutic approaches for IPF is an unmet clinical need. Nucleotide-binding oligomerization domain-like receptor or NOD-like receptors
Ruben M.L. Colunga Biancatelli, Pavel A. Solopov, John D. Catravas +2 more
openaire +2 more sources

Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors

Bioorganic & Medicinal Chemistry Letters, 2020
Aberrant activation of NLRP3 inflammasome is present in a subset of acute and chronic inflammatory diseases. The NLRP3 inflammasome has been recognized as an attractive therapeutic target for developing novel and specific anti-inflammatory inhibitors. Cellular structure-activity relationship-guided optimization resulted in the identification of 4-oxo-2-
Yun, Chen +8 more
openaire +2 more sources

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

Nature, 2021
Sangjoon Lee, , Yaqiu Wang
exaly

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

Science, 2020
Venkat Giri Magupalli, Roberto Negro, Yuzi Tian +2 more
exaly

Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis

Nature Immunology, 2020
Elaine F Remmers, Wonyong Lee, Amanda K Ombrello +2 more
exaly

Low Potassium Triggers Tubular Epithelial NLR Family Pyrin Domain-Containing 3/Apoptosis-Associated Speck-Like Protein-Containing a CARD–Driven Kidney Inflammation Independently of Inflammasomes