Results 41 to 50 of about 21,899 (194)

Insights into assembly of the macromolecular inflammasome complex [PDF]

, 2014
This is the published version. It first appeared at http://www.degruyter.com/view/j/infl.2013.1.issue-1/infl-2014-0009/infl-2014-0009.xml.AbstractDramatic advances in our understanding of the ultrastructure of the inflammasome and the molecular ...
Boyle, Joseph P, Monie, Tom P
core   +2 more sources

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition [PDF]

, 2019
The nucleotide-binding-domain (NBD)-and leucine-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome drives pathological inflammation in a suite of autoimmune, metabolic, malignant, and neurodegenerative diseases ...
Demon, Dieter, Fossoul, Amelie, Kayagaki, Nobuhiko, Konvalinka, Jan, Kostka, Libor, Lamkanfi, Mohamed, Lee, Bettina L, Pham, Victoria C, Sacha, Pavel, Simon, Petr, Staben, Steven T, Stivala, Craig E, Stowe, Irma B, Subrt, Vladimir, Van Hauwermeiren, Filip, Vande Walle, Lieselotte, Viana Saavedra, Pedro Henrique, Yamazoe, Sayumi   +17 more
core   +1 more source

PGC-1α agonist ZLN005 ameliorates OVA-induced asthma in BALB/c mice through modulating the NF-κB–p65/NLRP3 pathway [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Asthma is a complex inflammatory disease of the lungs marked by increased infiltration of leukocytes into the airways, which restricts respiratory function.
Rui Fang, Yan Cheng, Ping Chen, Jing Hu, Liqi Yang   +4 more
doaj   +1 more source

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

Effect of diosmetin on rats with liver fibrosis and its mechanism [PDF]

精准医学杂志
Objective To investigate the effect of diosmetin on rats with liver fibrosis and its mechanism. Methods A total of 60 specific pathogen-free male Sprague-Dawley rats were randomly divided into groups A, B, C, D, E, and F, with 10 rats in each group.
TAN Lixia, HUA Jing, YAN Chunxiao, WANG Hangyu, DONG Yong, WEI Shutang
doaj   +1 more source

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core   +3 more sources

Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice

Mediators of Inflammation, 2013
Alcoholic liver disease (ALD) is characterized by increased hepatic lipid accumulation (steatosis) and inflammation with increased expression of proinflammatory cytokines.
David A. DeSantis, Chih-wei Ko, Yang Liu, Xiuli Liu, Amy G. Hise, Gabriel Nunez, Colleen M. Croniger   +6 more
doaj   +1 more source

Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease

Biomedical Journal, 2023
Inflammation plays an important role in the pathophysiology of cardiometabolic diseases. Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP)-induced innate response, is now well-established to be closely associated with ...
Sungji Cho, Fan Ying, Gary Sweeney
doaj   +1 more source

Is the inflammasome a potential therapeutic target in renal disease? [PDF]

, 2014
The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cytoplasmic trigger inflammasome assembly. These
A Chen, A Covic, A Dorfleutner, A Fukami, A Granfeldt, A MacKenzie, A So, A Vilaysane, AA Shigeoka, AH Bani-Hani, AJ Puren, AM Karkar, AM Karkar, AN Economides, AS Yazdi, BA VanderBrink, BJ Pereira, C Dostert, C Hammerberg, CA Dinarello, CA Dinarello, CA Dinarello, CA Dinarello, CJ Chen, CL Edelstein, CL Myers, Clare M Turner, CM Turner, CM Turner, CM Yang, CR Parikh, D Choubey, D Ferrari, D Ferrari, D Nordstrom, D Sola-Villa, DG Perregaux, E Homsi, EA Kurt-Jones, EA Miao, EC Keystone, ED Siew, EM Kofoed, F Bauernfeind, F Knauf, F Turkmen, FG Bauernfeind, Frederick WK Tam, FW Tam, FW Tam, G Dell’Antonio, G Dell’Antonio, G Kaplanski, G Nuki, G Ren, GY Chen, H Harada, H Kohka, H Ranjbaran, H Saiga, H von Bernuth, H Wu, H Yamagishi, H Zhang, HJ Lachmann, HM Hoffman, HU Schorlemmer, HY Lan, I Jalilian, IC Allen, J Lichtnekert, J Wang, JC Morel, JL Levinsohn, JM Bruey, JM Kahlenberg, JR Timoshanko, K Furuichi, K Kersse, K Kinoshita, K Matsumoto, K Rusai, K Takeda, K Wareham, KL Williams, KM Sumpter, LK Parvathenani, M Hacham, M Haq, M Lech, M Mizobuchi, M Shiohara, M Sugiyama, M Takeuchi, M Tomura, MD Wewers, Mervyn Singer, MP Bevilacqua, N Arulkumaran, N Arulkumaran, N Kolliputi, N Ueno, NA Thornberry, NB Bryan, NB Bryan, Nishkantha Arulkumaran, O Gross, O Hertting, O Vonend, R Alten, R Goldbach-Mansky, R Imamura, RG Goncalves, Robert J Unwin, S Cornelis, S Deplano, S Gangemi, S Gauer, SC Whitman, SL Fernando, SL Fink, SR Ali, SR Mulay, SR Taylor, SR Taylor, SS Iyer, T Bergsbaken, T Bergsbaken, T Dao, T Fujita, T Porazko, TL Roberts, U Kavita, V Hurgin, V Pascual, W Wang, X Wang, Y Chung, Y le Meur, Y Liu, Y Zhao, Z Mallat, Z Ye   +142 more
core   +1 more source

C-type lectin-like receptors of the dectin-1 cluster : ligands and signaling pathways [PDF]

, 2013
Peer reviewedPublisher ...
Brown, Gordon D, Plato, Anthony, Willment, Janet A   +2 more
core   +1 more source