Results 101 to 110 of about 11,495 (207)
NLRP1 inflammasome contributes to chronic stress-induced depressive-like behaviors in mice
Journal of Neuroinflammation, 2020 Background Major depressive disorder (MDD) is a highly prevalent psychiatric disorder, and inflammation has been considered crucial components of the pathogenesis of depression.
Ao-Qi Song +7 more
doaj +1 more source
Insights into assembly of the macromolecular inflammasome complex [PDF]
, 2014 This is the published version. It first appeared at http://www.degruyter.com/view/j/infl.2013.1.issue-1/infl-2014-0009/infl-2014-0009.xml.AbstractDramatic advances in our understanding of the ultrastructure of the inflammasome and the molecular ...
Boyle, Joseph P, Monie, Tom P
core +2 more sources
Evaluation of ASC as a therapeutic target for Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract Neuroinflammation is increasingly recognized as a central contributor to the pathogenesis and progression of Alzheimer's disease (AD). The apoptosis‐associated speck‐like protein containing a CARD (ASC), encoded by the PYCARD gene, plays a critical role in the formation of multiple inflammasomes, including NLRP3, a key mediator of inflammation
W. Brent Clayton +12 more
wiley +1 more source
Journal of Neuroinflammation, 2020 Background Inhibition of inositol-requiring enzyme-1 alpha (IRE1α), one of the sensor signaling proteins associated with endoplasmic reticulum (ER) stress, has been shown to alleviate brain injury and improve neurological behavior in a neonatal hypoxic ...
Juan Huang +7 more
doaj +1 more source
Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes [PDF]
, 2012 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90366/1/j.1365-2249.2011.04535.x ...
Franchi, Luigi, Ozkurede, V. U.
core +1 more source
Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei +11 more
wiley +1 more source
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]
, 2018 Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S. +9 more
core +4 more sources
Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.This study reports a rare case of bone marrow failure syndrome type 1 (BMFS1) caused by a novel de novo splicing mutation (c.1502+1G>A) in the SRP72 gene. The 6‐year‐old patient presented with aplastic anemia and pancytopenia. Genetic analysis identified the mutation, which was absent in both parents, confirming its de novo origin.
Wang Xiangwen +3 more
wiley +1 more source
بررسی ارتباط فاکتورهای حفظ و بازسازیکننده پیوندگاه عصبی- عضلانی با فاکتورهای التهابی هیپوکامپ تحت تأثیر تمرین ورزشی شنا در موشهای مدل آلزایمری [PDF]
مجله دانشگاه علوم پزشکی سبزوارزمینه و هدف: ورزش یک گزینه غیردارویی امیدوارکننده برای بهتأخیرانداختن بالقوه شروع یا کندکردن پیشرفت آلزایمر است از اینرو این پژوهش درصدد یافتن مکانیسم احتمالی ارتباط عضله و هیپوکمپ تحت تأثیر تمرین ورزشی شنا در رتهای مبتلا به آلزایمر است. مواد و روشها:
محمد سلیمانی فارسانی +3 more
doaj +1 more source
What makes gouty inflammation so variable? [PDF]
, 2017 Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem.
Terkeltaub, Robert
core +2 more sources