Results 111 to 120 of about 11,495 (207)

P2X4 promotes interleukin-1β production in osteoarthritis via NLRP1

Molecular Medicine Reports, 2013
Interleukin‑1β (IL‑1β) has a significant role in osteoarthritis (OA). The purinergic receptor, P2X4, has previously been implicated in IL‑1β secretion. The NLRP1 inflammasome mediates the production of IL‑1β in inflammatory disorders. However, it is unknown whether P2X4 modulates NLRP1‑mediated IL‑1β release.
Changchun, Fan, Xuechun, Zhao, Xiaofan, Guo, Xuecheng, Cao, Jinfang, Cai   +4 more
openaire   +3 more sources

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized [PDF]

, 2013
The caspase recruitment domain (CARD) is present in death-domain superfamily proteins involved in inflammation and apoptosis. BinCARD is named for its ability to interact with Bcl10 and inhibit downstream signalling.
Adams, Alba, Anderson, Arnoult, Ayanthi A. Richards, Baker, Bostjan Kobe, Chen, Chou, Combet, Coussens, Dai, Edeling, Emsley, Ferrage, Garman, Gautier Robin, Hiscott, Holm, Hou, Humke, Jennifer Martin, Justine M. Hill, Kabsch, Kai-En Chen, Kate Schroder, Kay, Kersse, Li, Linda H. L. Lua, Lopez, Lu, Matthew J. Sweet, McPhillips, Meissner, Notredame, Parimala R. Vajjhala, Park, Pruitt, Puri, Qin, Rapaport, Richards, Richards, Rolland, Ruland, Salsbury, Schroder, Schwartz, Scott, Seth, Sheldrick, Shiozaki, Srimathi, Stols, Stuart Kellie, Studier, Thome, Tom T. Caradoc-Davies, Vaughn, Vonrhein, Whitehead, Winn, Woo, Zhou, Zuo   +65 more
core   +1 more source

Study on the Modulation of NLRP1 by Natural Products in Neurodegenerative Diseases

Natural Product Communications
Neuronal pyroptosis is one of the crucial pathogenesis of neurodegenerative diseases, and the signaling pathway mediated by inflammasome is the main pathway of pyroptosis.
Ting-ting Wang, Xin-tong Zuo, Ling Cheng, Nan Shao, Peng Zhou   +4 more
doaj   +1 more source

Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress.

PLoS ONE, 2015
Perturbation of endoplasmic reticulum (ER) homeostasis triggers the ER stress response (also known as Unfolded Protein Response), a hallmark of many pathological disorders.
Andrea D'Osualdo, Veronica G Anania, Kebing Yu, Jennie R Lill, Randal J Kaufman, Shu-ichi Matsuzawa, John C Reed   +6 more
doaj   +1 more source

NLRP1 inflammasome activation in schizophrenia

FENS Forum 2024
Abstract body: Aims: In the context of the maternal immune activation and neuroinflammation hypotheses of schizophrenia (SZ), we studied NLRP1 mRNA and protein expression in the postmortem brain tissue from a total of 10 SZ and 10 controls. Methods: RNA underwent reverse transcription and was hybridized onto the Affymetrix HG-U133 Plus 2.0 array, using
Krsnik, Željka, Mladinov, Mihovil, Šimić, Goran, Šagud, Marina, Marčinko, Darko, Babić Leko, Mirjana, Langer Horvat, Lea, Kopić, Janja   +7 more
openaire   +1 more source

A Prospective Cohort Study of Elevated Serum NLRP1 Levels to Prognosticate Neurological Outcome After Acute Intracerebral Hemorrhage at a Single Academic Institution

Neuropsychiatric Disease and Treatment
Wei Li,1,2 Jun Wang,1,2 Chao Tang,1,2 Xuan Lv,1,2 Suijun Zhu1,2 1Department of Neurosurgery, First People’s Hospital of Linping District, Hangzhou, People’s Republic of China; 2Department of Neurosurgery, Linping Campus, the Second Affiliated Hospital of
Li W, Wang J, Tang C, Lv X, Zhu S
doaj  

Comparison of Different Keratinocyte Cell Line Models for Analysis of NLRP1 Inflammasome Activation

Biomolecules
The NLRP1 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-1) inflammasome is the most important inflammasome in human keratinocytes. It plays a crucial role in regulating innate immunity in the skin.
Tian Wang, Amir S. Yazdi, Diana Panayotova-Dimitrova   +2 more
doaj   +1 more source

Schizophrenia is a TH2 dominant autoimmune disease possibly against acetylcholine receptors of CNS [PDF]

, 2012
Schizophrenia is a very common psychiatric disorder. However, its etiology and pathogenesis is still unknown. Current theory saying that neurotransmitter imbalance such as serotonin or dopamine only provides limited effectiveness in schizophrenia ...
Wanchung(Wan-Jiung) Hu
core   +1 more source

Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia

Biomolecules
Schizophrenia is a complex mental condition, with key symptoms marked for diagnosis including delusions, hallucinations, disorganized thinking, reduced emotional expression, and social dysfunction.
Ena Španić Popovački, Dora Vogrinc, Heidi R. Fuller, Lea Langer Horvat, Davor Mayer, Janja Kopić, Klara Pintarić, Mirjana Babić Leko, Mihaela Pravica, Željka Krsnik, Darko Marčinko, Marina Šagud, Patrick R. Hof, Mihovil Mladinov, Goran Šimić   +14 more
doaj   +1 more source

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer’s disease

Neural Regeneration Research
Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer’s disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation.
Gabriela Seplovich, Yazan Bouchi, Juan Pablo de Rivero Vaccari, Jennifer C. Munoz Pareja, Andrew Reisner, Laura Blackwell, Yehia Mechref, Kevin K. Wang, J. Adrian Tyndall, Binu Tharakan, Firas Kobeissy   +10 more
doaj   +1 more source