Results 171 to 180 of about 11,495 (207)

Gastrointestinal microbiota and inflammasomes interplay in health and disease: a gut feeling. [PDF]

Gut
De Luca R, Arrè V, Nardone S, Incerpi S, Giannelli G, Trivedi P, Anastasiadou E, Negro R.   +7 more
europepmc   +1 more source

Identifying the causal role and therapeutic potential of immune-related genes in bladder cancer: a Mendelian randomization study. [PDF]

Discov Oncol
Chen Y, Yu Q, Jiang X, Li L, Kang L.
europepmc   +1 more source

Clarifying the priming requirement and activator specificity for the NLRP3 inflammasome in human keratinocytes in vitro

Rozario P, Lim YS, Ding SSL, Firdaus MJ, Wearne S, Brandon WHS, Chua R, Robinson KS, Chu JTS, Meng L, Cai SSC, Tan STE, Wee SK, Lamers MM, Verma NK, Yun X, Yap EPH, Common JEA, Zhong F.   +18 more
europepmc   +1 more source

The NLRP1 and CARD8 inflammasomes [PDF]

Immunological Reviews, 2020
AbstractInflammasomes are multiprotein complexes that activate inflammatory cytokines and induce pyroptosis in response to intracellular danger‐associated signals. NLRP1 and CARD8 are related germline‐encoded pattern recognition receptors that form inflammasomes, but their activation mechanisms and biological purposes have not yet been fully ...
Cornelius Y Taabazuing, Andrew R Griswold, Daniel A Bachovchin   +2 more
exaly   +3 more sources

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DPP9 restrains NLRP1 activation

Nature Structural & Molecular Biology, 2021
NLRP1 was the first inflammasome-forming sensor to be identified, but only recently has its mode of action been in the spotlight. Two groups now report cryo-EM structures demonstrating how NLRP1 is kept in check by the dipeptidyl peptidase DPP9, and they illuminate how DPP9 inhibition leads to NLRP1 inflammasome activation.
Stefan Bauernfried, Veit Hornung
openaire   +2 more sources

Human NLRP1 is a sensor for double-stranded RNA

Science, 2021
A dsRNA detector in the immune toolkit Nod-like receptor (NLR) proteins recognize pathogen-associated molecular patterns within cells, which triggers the formation of signaling complexes called inflammasomes. These complexes then initiate pyroptosis, a highly inflammatory form of cell death.
Stefan Bauernfried, Matthias J Scherr, Andreas Pichlmair   +2 more
exaly   +4 more sources

The NLRP1 Inflammasome in Human Skin and Beyond [PDF]

International Journal of Molecular Sciences, 2020
Inflammasomes represent a group of protein complexes that contribute to host defense against pathogens and repair processes upon the induction of inflammation. However, aberrant and chronic inflammasome activation underlies the pathology of numerous common inflammatory diseases. Inflammasome assembly causes activation of the protease caspase-1 which in
Gabriele Fenini, Tugay Karakaya, Paulina M Hennig   +2 more
exaly   +4 more sources

The NLRP1 and CARD8 inflammasomes detect reductive stress

Cell Reports, 2023
The danger signals that activate the related nucleotide-binding domain leucine-rich repeat pyrin domain-containing 1 (NLRP1) and caspase activation and recruitment domain-containing 8 (CARD8) inflammasomes have not been fully established. We recently reported that the oxidized form of TRX1 binds to NLRP1 and represses inflammasome activation.
Jeffrey Chieh Hsiao, Noah Yardeny, Hsin-Che Huang   +2 more
exaly   +3 more sources

Oxidized thioredoxin-1 restrains the NLRP1 inflammasome

Science Immunology, 2022
The danger signals that activate the NLRP1 inflammasome have not been established. Here, we report that the oxidized, but not the reduced, form of thioredoxin-1 (TRX1) binds to NLRP1. We found that oxidized TRX1 associates with the NACHT-LRR region of NLRP1 in an ATP-dependent process, forming a stable complex that restrains inflammasome activation ...
Daniel P. Ball, Lydia P. Tsamouri, Alvin E. Wang, Hsin-Che Huang, Charles D. Warren, Qinghui Wang, Isabelle H. Edmondson, Andrew R. Griswold, Sahana D. Rao, Darren C. Johnson, Daniel A. Bachovchin   +10 more
openaire   +2 more sources

Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation

Cell Reports, 2023
NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular danger signals and form inflammasomes. Both undergo autoproteolysis, generating N-terminal (NT) and C-terminal (CT) fragments. The proteasome-mediated degradation of the NT releases the CT from autoinhibition, but the stimuli that trigger NT degradation have not ...
Hsin-Che Huang, Ashley J Chui, Andrew R Griswold   +2 more
exaly   +3 more sources