Results 161 to 170 of about 9,154 (185)

NLRP1 inflammasome in neurodegenerative disorders: From pathology to therapies

Cytokine & Growth Factor Reviews
Neuroinflammation is a critical component in neurodegenerative disorders. The inflammasome, facilitates the cleavage of caspase-1, leading to the maturation and subsequent secretion of inflammatory factors interleukin (IL)-1β and IL-18. Consequently, pyroptosis mediated by gasdermin D, exacerbates neuroinflammation. Among the inflammasomes, NLRP1/3 are
Meng-Jie, Zhang, Long, Yang, Zhuo-Yao, Li, Long-Yun, Zhou, Yong-Jun, Wang, Hong-Shen, Wang, Xue-Jun, Cui, Min, Yao   +7 more
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Methods to Activate the NLRP1 Inflammasome

2023
In addition to being the first NLR protein proposed to form inflammasome, NLRP1s have attracted much attention in their activation mechanism by post-translational auto-proteolysis to generate C-terminal CARD containing fragment to form inflammasome. Among NLRP1, mouse NLRP1B but not human NLRP1 is well studied for its activation by lethal toxin.
Hang, Gao, Pan, Liu, Na, Dong
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NEK7 activates the NLRP1 Inflammasome

2022
AbstractInflammasomes including those assembled by NLRP1 and NLRP3 regulate the innate immune system by inducing interleukin (IL)-1β and IL-18 maturation. Inflammasomes are functionally regulated by post-translational modifications such as phosphorylation.
Inés Muela-Zarzuela, Andrea Gallardo-Orihuela, Almudena Pino-Ángeles, Juan Miguel Suarez-Rivero, Daniel Boy-Ruiz, Marta de Gregorio-Procopio, Javier Oroz, Gabriel Mbalaviele, Mario D. Cordero   +8 more
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Nlrp1 inflammasome is downregulated in trauma patients

Journal of Molecular Medicine, 2015
After a major trauma, IL-1β-producing capacity of monocytes is reduced. Generation of IL-1β is important for appropriate immune response after trauma and requires not only synthesis and transcription of inflammasome components but also their activation.
B, Relja, J P, Horstmann, K, Kontradowitz, K, Jurida, A, Schaible, C, Neunaber, E, Oppermann, I, Marzi   +7 more
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Reconstituting the NLRP1 Inflammasome In Vitro

2013
Nucleotide-binding domain leucine-rich-repeat containing receptors; NOD-Like Receptors (NLRs) were originally described as microbial sensors involved in host defense against pathogens that comprise an important component of the innate immune system. Recently, their cellular functions have expanded beyond classical pathogen detection, to danger sensors ...
Benjamin, Faustin, John C, Reed
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CARD8 negatively regulates NLRP1 inflammasome activation level by interaction with NLRP1

2022
AbstractNLRP1 inflammasome functions as canonical cytosolic sensor in response to intracellular infections and is implicated in auto-inflammatory diseases. But the regulation and signal transduction mechanisms of NLRP1 are incompletely understood. Here, we show that the T60 variant of CARD8, but not the canonical T48 isoform, negatively regulates NLRP1
Zhihao Xu, Shasha Deng, Yuluo Huang, Yunru Yang, Liangqi Sun, Hanyuan Liu, Dan Zhao, Weihong Zeng, Xueying Yin, Peiyi Zheng, Muziying Liu, Weidong Zhao, Ying Zhou, Tengchuan Jin   +13 more
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NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype

2023
AbstractSenescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as the senescence-associated secretory phenotype (SASP). Here, we present evidence that the inflammasome sensor, NLRP1, is a key mediator of senescence induced by irradiation both in vitro
Ines, Muela-Zarzuela, Juan M, Suarez-Rivero, Andrea, Gallardo-Orihuela, Chun, Wang, Kumi, Izawa, Marta, de Gregorio-Procopio, Isabelle, Couillin, Bernhard, Ryffel, Jiro, Kitaura, Alberto, Sanz, Thomas, von Zglinicki, Gabriel, Mbalaviele, Mario D, Cordero   +12 more
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The NLRP1 inflammasomes

Immunological Reviews, 2015
SummaryInflammasomes are cytosolic protein complexes that serve as platforms for the recruitment and activation of the pro‐inflammatory CASPASE‐1 protease. CASPASE‐1 activation leads to processing and maturation of the cytokines interleukin‐1β and interleukin‐18 and a lytic form of cell death termed pyroptosis.
Joseph, Chavarría-Smith, Russell E, Vance   +1 more
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Neuroinflammation in Alzheimer’s Disease: Focus on NLRP1 and NLRP3 Inflammasomes

Current Protein & Peptide Science, 2021
Background: Alzheimer’s disease (AD) is the main cause of dementia worldwide. The definitive diagnosis of AD is clinicopathological and based on the identification of cerebral deposition of Amyloid β (Aβ) plaques and neurofibrillary tangles. However, the link between amyloid cascade and depositions of phosphorylated tau (p-tau) is still missing.
Eliana C. de Brito Toscano, Natalia P. Rocha, Beatriz N. A. Lopes, Claudia K. Suemoto, Antonio L. Teixeira   +4 more
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The NLRP1 and CARD8 inflammasomes detect reductive stress

2022
The danger signals that activate the NLRP1 and CARD8 inflammasomes have not been fully established. We recently discovered that cytosolic peptide accumulation activates these inflammasomes. In addition, we found that the oxidized form of TRX1 binds to and represses NLRP1, suggesting that NLRP1 also detects a lack of reactive oxygen species, or ...
Qinghui Wang, Jeffrey Hsiao, Noah Yardeny, Hsin-Che Huang, Claire M. O'Mara, Elizabeth L. Orth-He, Daniel P. Ball, Daniel A. Bachovchin   +7 more
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