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Oxidized thioredoxin 1 places a leash on
AbstractThe biology of the NACHT domain and leucine‐rich repeat (NLR) and pyrin domain‐containing 1 (NLRP1) inflammasome has perplexed researchers since this inflammasome was first described about two decades ago. The identification of oxidized thioredoxin 1 (TRX1) as a suppressor of NLRP1 recently linked cellular redox homeostasis to NLRP1 ...
Jeremy Ky, Yap +2 more
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Cytosolic peptide accumulation activates the NLRP1 and CARD8 inflammasomes
2022NLRP1 and CARD8 are related sensors that form inflammasomes, but the danger signals that they detect are not fully established. These proteins undergo autoproteolysis, generating repressive N-terminal (NT) and inflammatory C-terminal (CT) fragments. The proteasome-mediated degradation of the NT releases the CT from autoinhibition, but the CT is then ...
Elizabeth L. Orth-He +12 more
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Viral protein activates the NLRP1 inflammasome
Nature Immunology, 2022Ella Hartenian, Petr Broz
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A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases
Cell, 2023Katherine C Barnett, Kaixin Liang
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Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia
Science, 2020Kim S Robinson +2 more
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IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome
Cell Metabolism, 2016Michael J Kraakman +2 more
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