Results 231 to 240 of about 135,752 (336)

Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti‐PD‐1 immunotherapy efficacy in colorectal cancer liver metastasis

open access: yesCancer Communications, EarlyView.
Abstract Background Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor‐associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM.
Yizhi Zhan   +11 more
wiley   +1 more source

Neutrophil Extracellular Trap–Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages [PDF]

open access: bronze, 2012
J. Michelle Kahlenberg   +3 more
openalex   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves   +3 more
wiley   +1 more source

The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release

open access: bronze, 2011
Tobias Hoegen   +9 more
openalex   +1 more source

Catalytic SuFEx Reactivity of Sulfonimidoyl Fluorides with Functionalized Amines with Automation Applicable Conditions

open access: yesChemistryEurope, EarlyView.
GA: Sulfonimidoyl fluorides react with a diverse set of amines in a HOBt‐catalyzed sulfur(VI) fluorine exchange reaction to access sulfonimidamides, including directly NH‐sulfonimidamides, and in an automated workflow. In addition, SNAr reactivity of 4‐fluoroaryl sulfonimidoyl fluorides is discovered and exploited to prepare complex sulfonimidoyl ...
Dominique Deans   +6 more
wiley   +1 more source

Molecular Mechanism of NLRP3 Inflammasome in Inflammatory Diseases and Tumors. [PDF]

open access: yesImmun Inflamm Dis
Gong LL   +6 more
europepmc   +1 more source

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

open access: bronze, 2011
Jae Jin Chae   +7 more
openalex   +1 more source

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