Results 271 to 280 of about 135,870 (288)

Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation

Cell Death & Differentiation, 2022
The NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome plays a pivotal role in defending the host against infection as well as sterile inflammation. Activation of the NLRP3 inflammasome is critically regulated by a de-ubiquitination mechanism, but little is known about how ubiquitination restrains NLRP3 activity. Here, we showed that
Ting Xu, Weiwei Yu, Hui Fang, Zhen Wang, Zhexu Chi, Xingchen Guo, Danlu Jiang, Kailian Zhang, Sheng Chen, Mobai Li, Yuxian Guo, Jian Zhang, Dehang Yang, Qianzhou Yu, Di Wang, Xue Zhang   +15 more
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Assessment of NLRP3 Inflammasome Activation and NLRP3-NEK7 Complex Assembly

2023
The NLRP3 inflammasome is a critical component of innate immunity that activates caspase-1 to induce inflammation in response to a wide spectrum of endogenous and exogenous stimuli. NLRP3 inflammasome activation has been shown by assays for the cleavage of caspase-1 and gasdermin D, the maturation of IL-1β and IL-18, and ASC speck formation in innate ...
Nathan, Kelley, Yuan, He
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USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3

Autophagy, 2021
3-MA: 3-methyladenine; AIM2: absent in melanoma 2; ATG5: autophagy related 5; BafA1: bafilomycin A1; CASP1: caspase 1; CHX: cycloheximide; Co-IP: co-immunoprecipitation; CQ: chloroquine; DUBs: deubiquitinases; IL1B/IL-1β: interleukin 1 beta; LAMP1: lysosomal associated membrane protein 1; LPS: lipopolysaccharide; MARCHF7/MARCH7: membrane associated ...
Baoshan Cai, Jian Zhao, Yuling Zhang, Yaxing Liu, Chunhong Ma, Fan Yi, Yi Zheng, Lei Zhang, Tian Chen, Huiqing Liu, Bingyu Liu, Chengjiang Gao   +11 more
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ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation

Molecular Cell, 2023
The nucleotide-binding domain (NBD), leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3 (NLRP3) inflammasome is a critical mediator of the innate immune response. How NLRP3 responds to stimuli and initiates the assembly of the NLRP3 inflammasome is not fully understood.
Sihao Zheng, Xiangyong Que, Shuxian Wang, Qi Zhou, Xiaoke Xing, Liang Chen, Chunyan Hou, Junfeng Ma, Ping An, Yihan Peng, Yi Yao, Qibin Song, Juanjuan Li, Pingfeng Zhang, Huadong Pei   +14 more
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LMP7 inhibits the activation of NLRP3 inflammasome through interaction with NLRP3

Biochemical and Biophysical Research Communications, 2020
The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) by coding pattern recognition receptors (PRRs). As a well-known inflammasome, NLRP3 plays an essential role in helping the host immune response and driving antiviral processes.
Jing Jin, Wenbiao Wang, Aixin Li, Jianguo Wu   +3 more
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IκBζ controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene

Cytokine, 2020
Inflammasome activation induces the maturation and secretion of interleukin (IL)-1β and -18, and is dependent on NF-κB signaling to induce the transcription of the inflammasome components, called the priming step. This study elucidated the role of IκBζ, an atypical IκBs (inhibitor of κB) and a coactivator of NF-κB target genes, on the activation of ...
Jeongeun, Kim, Huijeong, Ahn, Sangjung, Yu, Jae-Hee, Ahn, Hyun-Jeong, Ko, Mi-Na, Kweon, Eui-Ju, Hong, Beum-Soo, An, Eunsong, Lee, Geun-Shik, Lee   +9 more
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NLRP3 inflammasome in sepsis (Review)

Molecular Medicine Reports, 2021
Sepsis is an imbalanced response to infection that leads to life-threatening organ dysfunction. Although an increasing number of anti-inflammatory drugs are available, the options for treating sepsis remain limited. Therefore, it is imperative to understand the pathogenesis and pathophysiology of sepsis and develop novel therapeutic targets to treat ...
Xueyan, Shi, Sichuang, Tan, Sipin, Tan
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Novel Macrocyclic NLRP3 Inhibitors

Journal of Medicinal Chemistry
Aberrant activation of NLRP3 due to persistent tissue damage, misfolded proteins or crystal deposits has been linked to multiple chronic inflammatory disorders such as cryopyrin-associated periodic syndrome (CAPS), neurodegenerative diseases, gouty arthritis, and numerous others.
Stefanie Mesch, Jonathan Shannon, David Miller, Angus MacLeod, Léa Bouché, Heather J. Johnston, Kim Matthews, Axel Paehler, Stuart Best, Wolfgang Guba, Thomas Alanine, Reena Halai, Lorna Charge, Samantha Garside, Stephen Thom, Celia Incerti-Pradillos, Christopher McPherson, Jokin Carrillo, Steve St-Gallay, Pierre Rigo, Sonja Schlicht, Alan G. Hendrick, Christian Lerner, Luca Piali, Julie Blaising, Eva Z. Mracsko, Georg Jaeschke, Matthew A. Cooper   +27 more
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Vasculitis and the NLRP3 inflammasome

Current Opinion in Rheumatology, 2023
Purpose of review Vasculitis are a group of heterogeneous conditions characterized by chronic inflammation of blood vessels, leading to tissue destruction and organ failure. Vasculitis is an inflammatory process in which immune effector cells infiltrate blood vessels and surrounding tissues.
Kamel, Hamzaoui, Agnès, Hamzaoui
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The NLRP3 Conundrum

Arthritis & Rheumatology, 2023
James T. Rosenbaum, Tejpal Gill, Tammy M. Martin   +2 more
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