Results 1 to 10 of about 91,161 (237)

Time-of-day control of mitochondria regulates NLRP3 inflammasome activation in macrophages. [PDF]

FASEB J
Macrophages are innate immune cells that orchestrate the process of inflammation, which varies across time of day. This ensures appropriate biological timing of the immune response with the external environment.
O'Siorain JR, Cox SL, Payet C, Nally FK, He Y, Drewinksi TT, Kennedy OD, Dowling JK, Mellett M, Early JO, Curtis AM.   +10 more
europepmc   +3 more sources

Magnesium-enriched deep-sea water inhibits NLRP3 inflammasome activation and dampens inflammation [PDF]

Heliyon
The NLRP3 inflammasome is an essential component of the innate immune system, but excessive activation can lead to inflammatory diseases. Ion fluxes across the plasma membrane or from intracellular stores are known to regulate NLRP3 inflammasome ...
Hsueh-Hsiao Wang, Chi-Ruei Huang, Hsin-Chung Lin, Hsin-An Lin, Yu-Jen Chen, Kuen-Jou Tsai, Chieh-Tien Shih, Kuo-Yang Huang, David M. Ojcius, Ming-Hang Tsai, Kuang-Wen Tseng, Lih-Chyang Chen   +11 more
doaj   +3 more sources

Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome

eLife, 2022
Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by mutations of NLRP3 gene encoding cryopyrin. Familial cold autoinflammatory syndrome, the mildest form of CAPS, is characterized by cold-induced inflammation induced ...
Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Emi Aizawa, Yoshiko Mizushina, Sachiko Watanabe, Chintogtokh Baatarjav, Takayoshi Matsumura, Masafumi Takahashi   +8 more
doaj   +1 more source

C646 Protects Against DSS-Induced Colitis Model by Targeting NLRP3 Inflammasome

Frontiers in Pharmacology, 2021
Numerous pieces of evidence have identified that the NLRP3 inflammasome plays a pivotal role in the development and pathogenesis of colitis. Targeting the NLRP3 inflammasome represents a potential therapeutic treatment.
Xueming Xu, Jing Li, Xiuyan Long, Sifan Tao, Xiaoyu Yu, Xixian Ruan, Kai Zhao, Li Tian   +7 more
doaj   +1 more source

NLRP3 monomer Functional Dynamics: from the Effects of Allosteric Binding to Implications for Drug Design [PDF]

International Journal of Biological Macromolecules 246 (2023) 125609, 2023
The protein NLRP3 and its complexes are associated with an array of inflammatory pathologies, among which neurodegenerative, autoimmune, and metabolic diseases. Targeting the NLRP3 inflammasome represents a promising strategy for easing the symptoms of pathologic neuroinflammation.
arxiv   +1 more source

Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo

Frontiers in Pharmacology, 2021
The abnormal activation of the NLRP3 inflammasome is closely related to the occurrence and development of many inflammatory diseases. Targeting the NLRP3 inflammasome has been considered an efficient therapy to treat infections.
Ziying Wei, Ziying Wei, Xiaoyan Zhan, Xiaoyan Zhan, Kaixin Ding, Kaixin Ding, Guang Xu, Wei Shi, Lutong Ren, Lutong Ren, Zhie Fang, Tingting Liu, Xiaorong Hou, Jia Zhao, Hui Li, Hui Li, Jiayi Li, Jiayi Li, Zhiyong Li, Qiang Li, Li Lin, Yan Yang, Xiaohe Xiao, Xiaohe Xiao, Zhaofang Bai, Zhaofang Bai, Junling Cao, Junling Cao   +27 more
doaj   +1 more source

Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases [PDF]

, 2021
Aberrant activation of the nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome drives the development of many complex inflammatory diseases, such as obesity, Alzheimer\u27s disease, and ...
Alvarez, Sophie, Chung, Soonkyu, Jing, Lili, Kachman, Stephen D, Li, Xingzhi, Liu, Baolong, Naldrett, Michael J, Ro, Seung-Hyun, Shi, Xuan, Sun, Xinghui, Yu, Han, Yu, Jiujiu, Zhou, You   +12 more
core   +3 more sources

The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3

Frontiers in Immunology, 2021
The dysregulation of NLRP3 inflammasome plays a critical role in pathogenesis of various human inflammatory diseases, thus NLRP3 inflammasome activation must be tightly controlled at multiple levels.
Tiantian Tang, Ping Li, Xinhui Zhou, Rui Wang, Xiuqin Fan, Mengyi Yang, Kemin Qi   +6 more
doaj   +1 more source

Cytochrome c Negatively Regulates NLRP3 Inflammasomes. [PDF]

PLoS ONE, 2016
The release of cytochrome c from the inner mitochondrial membrane, where it is anchored by caridolipin, triggers the formation of the Apaf-1 apoptosome. Cardiolipin also interacts with NLRP3 recruiting NLRP3 to mitochondria and facilitating inflammasome ...
Chong-Shan Shi, John H Kehrl
doaj   +1 more source

NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features

Frontiers in Immunology, 2020
The NLRP3 inflammasome is central to host defense and implicated in various inflammatory diseases and conditions. While the favored paradigm of NLRP3 inflammasome activation stipulates a unifying signal intermediate that de-represses NLRP3, this view has
Tabassum Rahman, Abhinit Nagar, Ellen B. Duffy, Kendi Okuda, Neal Silverman, Jonathan A. Harton   +5 more
doaj   +1 more source