Results 1 to 10 of about 115,042 (335)

Cytochrome c Negatively Regulates NLRP3 Inflammasomes. [PDF]

PLoS ONE, 2016
The release of cytochrome c from the inner mitochondrial membrane, where it is anchored by caridolipin, triggers the formation of the Apaf-1 apoptosome. Cardiolipin also interacts with NLRP3 recruiting NLRP3 to mitochondria and facilitating inflammasome ...
Chong-Shan Shi, John H Kehrl
doaj   +4 more sources

Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome

eLife, 2022
Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by mutations of NLRP3 gene encoding cryopyrin. Familial cold autoinflammatory syndrome, the mildest form of CAPS, is characterized by cold-induced inflammation induced ...
Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Emi Aizawa, Yoshiko Mizushina, Sachiko Watanabe, Chintogtokh Baatarjav, Takayoshi Matsumura, Masafumi Takahashi   +8 more
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C646 Protects Against DSS-Induced Colitis Model by Targeting NLRP3 Inflammasome

Frontiers in Pharmacology, 2021
Numerous pieces of evidence have identified that the NLRP3 inflammasome plays a pivotal role in the development and pathogenesis of colitis. Targeting the NLRP3 inflammasome represents a potential therapeutic treatment.
Xueming Xu, Jing Li, Xiuyan Long, Sifan Tao, Xiaoyu Yu, Xixian Ruan, Kai Zhao, Li Tian   +7 more
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Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo

Frontiers in Pharmacology, 2021
The abnormal activation of the NLRP3 inflammasome is closely related to the occurrence and development of many inflammatory diseases. Targeting the NLRP3 inflammasome has been considered an efficient therapy to treat infections.
Ziying Wei, Ziying Wei, Xiaoyan Zhan, Xiaoyan Zhan, Kaixin Ding, Kaixin Ding, Guang Xu, Wei Shi, Lutong Ren, Lutong Ren, Zhie Fang, Tingting Liu, Xiaorong Hou, Jia Zhao, Hui Li, Hui Li, Jiayi Li, Jiayi Li, Zhiyong Li, Qiang Li, Li Lin, Yan Yang, Xiaohe Xiao, Xiaohe Xiao, Zhaofang Bai, Zhaofang Bai, Junling Cao, Junling Cao   +27 more
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The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3

Frontiers in Immunology, 2021
The dysregulation of NLRP3 inflammasome plays a critical role in pathogenesis of various human inflammatory diseases, thus NLRP3 inflammasome activation must be tightly controlled at multiple levels.
Tiantian Tang, Ping Li, Xinhui Zhou, Rui Wang, Xiuqin Fan, Mengyi Yang, Kemin Qi   +6 more
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NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features

Frontiers in Immunology, 2020
The NLRP3 inflammasome is central to host defense and implicated in various inflammatory diseases and conditions. While the favored paradigm of NLRP3 inflammasome activation stipulates a unifying signal intermediate that de-represses NLRP3, this view has
Tabassum Rahman, Abhinit Nagar, Ellen B. Duffy, Kendi Okuda, Neal Silverman, Jonathan A. Harton   +5 more
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Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation

Cell Communication and Signaling, 2023
Background Idiosyncratic drug-induced liver injury (IDILI) is common in hepatology practices and, in some cases, lethal. Increasing evidence show that tricyclic antidepressants (TCAs) can induce IDILI in clinical applications but the underlying ...
Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Wenzhang Dai, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao   +12 more
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TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia

Cell Death and Disease, 2021
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome is considered an important regulator of immunity and inflammation, both of which play a critical role in MS.
Yahui Zhang, Baohua Hou, Peiyu Liang, Xin Lu, Yifan Wu, Xinyi Zhang, Yuanteng Fan, Yumin Liu, Taoxiang Chen, Wanhong Liu, Biwen Peng, Jun Yin, Song Han, Xiaohua He   +13 more
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A new acid isolated from V. negundo L. inhibits NLRP3 inflammasome activation and protects against inflammatory diseases

Frontiers in Immunology, 2023
The NLRP3 inflammasome plays a critical role in the innate immune response, and its excessive activation will cause pyroptotic cell death and be associated with the onset of inflammatory diseases. However, NLRP3 inflammasome targeting therapies are still
Qianqian Di, Xibao Zhao, Jing Lin, Xunwei Li, Xiaoli Li, Haimei Tang, Ruihan Zhang, Weilie Xiao, Weilin Chen   +8 more
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Posttranslational Regulation of the NLR Family Pyrin Domain-Containing 3 Inflammasome

Frontiers in Immunology, 2018
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that can be activated by a variety of pathogen-associated molecular patterns or damage-associated molecular patterns.
Do-Wan Shim, Kwang-Ho Lee, Kwang-Ho Lee
doaj   +1 more source