Results 21 to 30 of about 91,161 (237)

Regulation of NLRP3 Inflammasome by Phosphorylation [PDF]

Frontiers in Immunology, 2018
The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Upon activation, NLRP3 triggers the assembly of inflammasome via the self-oligomerization and the recruitment of apoptosis ...
Nan Song, Nan Song, Tao Li, Tao Li
openaire   +4 more sources

Role of the NLRP3 inflammasome in cancer [PDF]

Molecular Cancer, 2018
Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory ...
Maryam Moossavi, Negin Parsamanesh, Afsane Bahrami, Stephen L. Atkin, Amirhossein Sahebkar   +4 more
openaire   +3 more sources

Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation

Cell Communication and Signaling, 2023
Background Idiosyncratic drug-induced liver injury (IDILI) is common in hepatology practices and, in some cases, lethal. Increasing evidence show that tricyclic antidepressants (TCAs) can induce IDILI in clinical applications but the underlying ...
Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Wenzhang Dai, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao   +12 more
doaj   +1 more source

TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia

Cell Death and Disease, 2021
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome is considered an important regulator of immunity and inflammation, both of which play a critical role in MS.
Yahui Zhang, Baohua Hou, Peiyu Liang, Xin Lu, Yifan Wu, Xinyi Zhang, Yuanteng Fan, Yumin Liu, Taoxiang Chen, Wanhong Liu, Biwen Peng, Jun Yin, Song Han, Xiaohua He   +13 more
doaj   +1 more source

NLRP3 Inflammasome and Pathobiology in AMD [PDF]

Journal of Clinical Medicine, 2015
Age-related macular degeneration (AMD) is the leading cause of central vision loss and blindness in the elderly. It is characterized by a progressive loss of photoreceptors in the macula due to damage to the retinal pigment epithelium (RPE). Clinically, it is manifested by drusen deposition between the RPE and underlying choroid and accumulation of ...
Lucia Celkova, Matthew Campbell, Sarah L. Doyle   +2 more
openaire   +4 more sources

Posttranslational Regulation of the NLR Family Pyrin Domain-Containing 3 Inflammasome

Frontiers in Immunology, 2018
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that can be activated by a variety of pathogen-associated molecular patterns or damage-associated molecular patterns.
Do-Wan Shim, Kwang-Ho Lee, Kwang-Ho Lee
doaj   +1 more source

NLRP3 Inflammasome in the Pathogenesis of Miscarriages. [PDF]

Int J Mol Sci
Despite significant advances in prenatal medicine, spontaneous miscarriage remains one of the most common and serious pregnancy complications, affecting an increasing number of women. Since many aspects of the pathogenesis of spontaneous miscarriage remain unexplained, the aim of this study has been to assess the involvement of the NLRP3 inflammasome ...
Omeljaniuk WJ, Garley M, Pryczynicz A, Motyka J, Charkiewicz AE, Milewska E, Laudański P, Miltyk W.   +7 more
europepmc   +3 more sources

Cytoprotective Activated Protein C Averts Nlrp3 Inflammasome–Induced Ischemia-Reperfusion Injury Via Mtorc1 Inhibition [PDF]

, 2017
Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is associated with apoptosis inhibition. However, IRI is hallmarked by inflammation, and hence, cell-death forms disjunct from immunologically silent apoptosis are, in ...
Al-Dabet, Moh\u27d Mohanad, Bock, Fabian, Braun-Dullaeus, Ruediger C., Camerer, Eric, Dockendorff, Chris, Elwakiel, Ahmed, Esmon, Charles T., Gadi, Ihsan, Ghosh, Sanchita, Griffin, John H., Huber, Tobias B., Isermann, Berend, Kohli, Shrey, Manoharan, Jayakumar, Nazir, Sumra, Ranjan, Satish, Shahzad, Khurrum   +16 more
core   +2 more sources

Cardiolipin and the Nlrp3 Inflammasome [PDF]

Cell Metabolism, 2013
The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting ...
openaire   +5 more sources

A new acid isolated from V. negundo L. inhibits NLRP3 inflammasome activation and protects against inflammatory diseases

Frontiers in Immunology, 2023
The NLRP3 inflammasome plays a critical role in the innate immune response, and its excessive activation will cause pyroptotic cell death and be associated with the onset of inflammatory diseases. However, NLRP3 inflammasome targeting therapies are still
Qianqian Di, Xibao Zhao, Jing Lin, Xunwei Li, Xiaoli Li, Haimei Tang, Ruihan Zhang, Weilie Xiao, Weilin Chen   +8 more
doaj   +1 more source