Results 51 to 60 of about 115,042 (335)
Clinical and Translational Medicine, 2020 Inflammation is an important process involved in several cardiovascular diseases (CVDs), and nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a vital player in innate immunity and inflammation.
Yucheng Wang +6 more
doaj +1 more source
Targeting NLRP3 Inflammasome With Nrf2 Inducers in Central Nervous System Disorders
Frontiers in Immunology, 2022 The NLRP3 inflammasome is an intracellular multiprotein complex that plays an essential role in the innate immune system by identifying and eliminating a plethora of endogenous and exogenous threats to the host.
Bora Tastan +5 more
doaj +1 more source
Kidney surveillance in the spotlight: contrast-induced acute kidney injury illuminated [PDF]
, 2018 Acute kidney injury comprises a heterogeneous group of conditions characterized by a sudden decrease in renal function over hours to days. Contrast-induced acute kidney injury (CI-AKI) is caused by radiographic contrast agents used in diagnostic imaging.
Atkinson, Simon J.
core +1 more source
Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation
Frontiers in Immunology, 2021 Activation of the Nod-like receptor 3 (NLRP3) inflammasome is important for activation of innate immune responses, but improper and excessive activation can cause inflammatory disease.
Hsin-Chung Lin +13 more
doaj +1 more source
IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]
, 2014 The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S +19 more
core +1 more source
Molecular mechanisms regulating NLRP3 inflammasome activation [PDF]
Cellular & Molecular Immunology, 2015 Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NLRP3 inflammasome may be a promising
Eun-Kyeong, Jo +3 more
openaire +2 more sources
Acta Pharmaceutica Sinica B, 2019 Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic ...
Zhilei Wang +11 more
doaj +1 more source
Biomedical Journal, 2023 Background: The role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in the pathogenesis of hepatic encephalopathy (HE) is unclear. Mitochondrial reactive oxygen species (mtROS) is a signal for NLRP3 inflammasome
So Yeong Cheon +7 more
doaj +1 more source
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]
, 2018 Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S. +9 more
core +4 more sources
Cardiolipin and the Nlrp3 Inflammasome [PDF]
Cell Metabolism, 2013 The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting ...
openaire +4 more sources