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The miR-183 Cluster: Biogenesis, Functions, and Cell Communication via Exosomes in Cancer

Cells, 2023
Cancer is one of the leading causes of human death. MicroRNAs have been found to be closely associated with cancer. The miR-183 cluster, comprising miR-183, miR-96, and miR-182, is transcribed as a polycistronic miRNA cluster. Importantly, in most cases,
Shuhui Li, Wei Meng, Ziyi Guo, Min Liu, Yanyun He, Yanli Li, Zhongliang Ma   +6 more
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Genomewide m⁶A Mapping Uncovers Dynamic Changes in the m⁶A Epitranscriptome of Cisplatin-Treated Apoptotic HeLa Cells

Cells, 2022
Cisplatin (CP), which is a conventional cancer chemotherapeutic drug, induces apoptosis by modulating a diverse array of gene regulatory mechanisms. However, cisplatin-mediated changes in the m6A methylome are unknown.
Azime Akçaöz Alasar, Özge Tüncel, Ayşe Bengisu Gelmez, Buket Sağlam, İpek Erdoğan Vatansever, Bünyamin Akgül   +5 more
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IntiCom-DB: A Manually Curated Database of Inter-Tissue Communication Molecules and Their Communication Routes

Biology, 2023
Inter-tissue communication (ITC) is critical for maintaining the physiological functions of multiple tissues and is closely related to the onset and development of various complex diseases. Nevertheless, there is no well-organized data resource for known
Changxian Xiong, Yiran Zhou, Yu Han, Jingkun Yi, Huai Pang, Ruimao Zheng, Yuan Zhou   +6 more
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Transcriptomics Profiling Identifies Cisplatin-Inducible Death Receptor 5 Antisense Long Non-coding RNA as a Modulator of Proliferation and Metastasis in HeLa Cells

Frontiers in Cell and Developmental Biology, 2021
Cisplatin is a well-known cancer chemotherapeutic agent but how extensively long non-coding RNA (lncRNA) expression is modulated by cisplatin is unknown. It is imperative to employ a comprehensive approach to obtain a better account of cisplatin-mediated
Dilek Cansu Gurer, İpek Erdogan, Ulvi Ahmadov, Merve Basol, Merve Basol, Osama Sweef, Gulcin Cakan-Akdogan, Bünyamin Akgül   +7 more
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miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting androgen receptor in non-small cell lung cancer

Molecular Therapy: Nucleic Acids, 2021
Non-small cell lung cancer (NSCLC) is the most common form of cancer, resulting in cancer-related deaths worldwide. Exosomes, a subclass of extracellular vesicles, are produced and secreted from various types of cells, including cancer cells.
Jinbao Zhou, Hongshu Wang, Qiangling Sun, Xiaomin Liu, Zong Wu, Xianyi Wang, Wentao Fang, Zhongliang Ma   +7 more
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Tanshinone Inhibits NSCLC by Downregulating AURKA Through Let-7a-5p

Frontiers in Genetics, 2020
Lung cancer is the most deadly malignancy in the last decade, accounting for about 1.6 million deaths every year globally. Tanshinone is the constituent of Salvia miltiorrhiza; it has been found that they influence tumorigenesis.
Xiaomin Liu, Heng Zou, Yiqi Zhao, Hang Chen, Tanglin Liu, Zong Wu, Chenghao Yang, Qian Li, Yanli Li   +8 more
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Screening and Comprehensive Analysis of Cancer-Associated tRNA-Derived Fragments

Frontiers in Genetics, 2022
tRNA-derived fragments (tRFs) constitute a novel class of small non-coding RNA cleaved from tRNAs. In recent years, researches have shown the regulatory roles of a few tRFs in cancers, illuminating a new direction for tRF-centric cancer researches ...
Yiran Zhou, Yiran Zhou, Qinghua Cui, Qinghua Cui, Yuan Zhou, Yuan Zhou   +5 more
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Cellular senescence: A potential mode of circular RNAs regulating prostate cancer

MedComm – Oncology, 2023
Cellular senescence is a state characterized by permanent cell cycle stoppage, which has long been viewed as a protective mechanism against neoplasia. However, accumulating evidence reveal that cellular senescence variously stimulates tumorigenesis and ...
Yunpeng Li, Aoyu Fan, Yunyan Zhang, Ziyi Guo, Wei Meng, Wei Pan, Zhongliang Ma, Wei Chen   +7 more
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Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction

International Journal of Genomics, 2021
Diabetic foot ulcers are seriously endangering the physical and mental health of patients. Due to the long duration of inflammation, the treatment of nonhealing wounds in diabetes is one of the most prominent healthcare problems in the world. The nuclear
Xianyi Wang, Wanqiu Li, Shengdi Lu, Zhongliang Ma   +3 more
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A promising nucleic acid therapy drug: DNAzymes and its delivery system

Frontiers in Molecular Biosciences, 2023
Based on the development of nucleic acid therapeutic drugs, DNAzymes obtained through in vitro selection technology in 1994 are gradually being sought.
Lang Xiao, Lang Xiao, Yan Zhao, Meng Yang, Meng Yang, Guangxin Luan, Guangxin Luan, Ting Du, Ting Du, Shanshan Deng, Shanshan Deng, Xu Jia, Xu Jia   +12 more
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