Results 111 to 120 of about 100,759 (296)
Pharmaceutics, 2019 We previously reported that siRNA delivery to the brain is improved by the nose-to-brain delivery route and by conjugation with polyethylene glycol-polycaprolactone (PEG-PCL) polymer micelles and the cell-penetrating peptide, Tat (PEG-PCL-Tat).
Takanori Kanazawa +5 more
doaj +1 more source
, 2015 Long-standing neglect of the chemical senses in the philosophy of perception is due, mostly, to their being regarded as ‘lower’ senses. Smell, taste, and chemically irritated touch are thought to produce mere bodily sensations ...
Smith, Barry C.
core
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
BMEMat, EarlyView.A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie +12 more
wiley +1 more source
International Journal of Nanomedicine, 2023 Mustafa K Shehata,1 Assem A Ismail,1 Maher A Kamel2 1Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; 2Department of Biochemistry, Medical Research Institute, Alexandria University, Alexandria ...
Shehata MK, Ismail AA, Kamel MA
doaj
Nose to Brain Drug Delivery System
International Journal for Research in Applied Science and Engineering TechnologyAbstract: The treatment of brain disorders is particularly challenging due to the presence of a variety of formidable obstacles to deliver drugs selectively and effectively to the brain. Blood-brainbarrier (BBB) constitutes the major obstacle to the uptake of drugs into the brain following systemic administration.
openaire +1 more source
BMEMat, EarlyView.Organic field‐effect transistor (OFET)‐based biosensors are promising for wearable technology due to their flexibility and low cost, but their susceptibility to signal drift from mechanical stress and environmental factors remains a challenge. Here, we highlight a novel strategy that eliminates these drifts through a fundamental redesign of the OFET ...
Yan Xu, Bin Yao, Jiahe Wang, Yichun Ding
wiley +1 more source
AI + Drawing Enhances the Efficiency of Human Anatomy Education
Clinical Anatomy, EarlyView.ABSTRACT Human anatomy is a fundamental core course in medical education, and its teaching effectiveness directly influences students' understanding and application of medical knowledge. However, traditional anatomy instruction often faces challenges such as limited teaching resources and the high cognitive difficulty students experience.
Fangfang Zhou +3 more
wiley +1 more source
Barnes Hospital Bulletin [PDF]
, 1969 https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1030/thumbnail ...
core +1 more source
Decoding Emotional Signatures of Ethical Ads: An Analysis of Actor‐Viewer Synchrony
Journal of Consumer Behaviour, EarlyView.ABSTRACT We examine whether ethical advertisements differ from conventional ads in their on‐screen emotional signatures and whether those signatures transfer to actor‐viewer synchrony. Study 1 analyses 138 professionally produced YouTube ads using Automated Facial Expression Recognition (AFER) and Convolutional Neural Networks (CNN) to quantify actor ...
Vik Naidoo, Nicolas Hamelin
wiley +1 more source