Results 251 to 260 of about 100,759 (296)
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Nose to Brain Drug Delivery System
Research Journal of Pharmaceutical Dosage Forms and Technology, 2021The treatment of brain disorders is particularly challenging due to the presence of a variety of formidable obstacles to deliver drugs selectively and effectively to the brain. Blood-brain-barrier (BBB) constitutes the major obstacle to the uptake of drugs into the brain following systemic administration. An intranasal delivery provides some drugs with
Gayatri D Patil +3 more
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Nose-to-brain Delivery of Biologics
Therapeutic Delivery, 2019Graphical abstract.
Bettina, Schwarz, Olivia M, Merkel
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Nose-to-Brain Delivery of Peptides and Proteins
2023Abstract The fact that BBB is an important obstacle in drug delivery to the brain has revealed the need o try alternative drug administration routes. One of these alternative ways, also called non-invasive administrations, is intranasal drug administration.
Durgun, Meltem Ezgi +3 more
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Drug Delivery Systems from Nose to Brain
Current Pharmaceutical Biotechnology, 2012The treatment of brain disorders is particularly challenging due to the presence of a variety of formidable obstacles to deliver drugs selectively and effectively to the brain. Blood-brain-barrier (BBB) constitutes the major obstacle to the uptake of drugs into the brain following systemic administration.
Ambikanandan, Misra, Gitanjali, Kher
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Strategies for nose-to-brain drug delivery
Proceedings of the 8th International Workshop on Innovative Simulation for Healthcare (IWISH 2019), 2019"Intranasal drug administration is an effective method that has shown promise for delivering drugs directly to the brain. This approach is associated with many challenges, and efficacy in bypassing blood-brain barrier (BBB) is debated. This review describes the pathways of nose-to-brain drug delivery, physicochemical drug properties that influence drug
Rodrigo Quispe +3 more
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SLN approach for nose-to-brain delivery of alprazolam
Drug Delivery and Translational Research, 2012In the present study, alprazolam-loaded solid lipid nanoparticles were prepared and characterized. They were evaluated for their efficiency in nose-to-brain targeting and biodistribution in a suitable animal model after intranasal delivery. Solid lipid nanoparticles may offer an improvement to nose-to-brain drug delivery since they are able to protect ...
Alok Pratap, Singh +2 more
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Nanoparticles for direct nose-to-brain delivery of drugs
International Journal of Pharmaceutics, 2009This review aims to evaluate the evidence for the existence of a direct nose-to-brain delivery route for nanoparticles administered to the nasal cavity and transported via the olfactory epithelium and/or via the trigeminal nerves directly to the CNS.
Alpesh, Mistry +2 more
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Nose-to-brain peptide delivery – The potential of nanotechnology
Bioorganic & Medicinal Chemistry, 2018Nose-to-brain (N-to-B) delivery offers to protein and peptide drugs the possibility to reach the brain in a non-invasive way. This article is a comprehensive review of the state-of-the-art of this emerging peptide delivery route, as well as of the challenges associated to it.
Samaridou, Eleni, Alonso, Maria José
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Nanonized carbamazepine for nose-to-brain delivery: pharmaceutical formulation development
Pharmaceutical Development and Technology, 2023Epilepsy is one of the most common neurological disorders in the world. The therapeutic treatment is challenging since conventional drugs have limited efficacy and several side effects that impair patient management. Efforts are being made to find innovative strategies to control epileptic seizures. Intranasal administration provides a convenient route
Angela Bonaccorso +6 more
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Nose-to-brain delivery of lamotrigine-loaded PLGA nanoparticles
Drug Delivery and Translational Research, 2019Direct nose-to-brain delivery of drugs and faster onset of action have made intra-nasal route a much sought-after alternative to conventional routes of drug delivery to the brain. Lamotrigine is used for the treatment and management of neuropathic pain, and in the present work, lamotrigine (LTG)-PLGA nanoparticles were developed for intra-nasal ...
Kuldeep Nigam +6 more
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