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Nrf2–ARE signaling pathway and natural products for cancer chemoprevention
Cancer Epidemiology, 2010One of the potential strategies for preventing cancers is using food-based natural products to induce cytoprotective enzymes including phase II and antioxidative enzymes that act in concert to detoxify and eliminate harmful reactive intermediates formed from carcinogens.
Cui Rong, Zhao +2 more
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The Power of Daphnetin: Enhancing Nrf2 Signaling Pathway
Life Sciences Student JournalChronic inflammation and oxidative stress are involved in a range of diseases. The Nrf2 pathway is crucial in controlling cellular defenses against stresses. Daphnetin (DAP), a compound derived from plants such as Daphne odora, has shown promise to activate Nrf2, a protein with potential therapeutic uses.
Modarresi Chahardehi, Amir +4 more
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The role of Nrf2 signaling pathways in nerve damage repair
Toxicology ResearchAbstractThe protein, Nuclear factor-E2-related factor 2 (Nrf2), is a transitory protein that acts as a transcription factor and is involved in the regulation of many cytoprotective genes linked to xenobiotic metabolism and antioxidant responses. Based on the existing clinical and experimental data, it can be inferred that neurodegenerative diseases are
Arash Abdolmaleki +6 more
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Targeting Nrf2 signaling pathway: new therapeutic strategy for cardiovascular diseases
Journal of Drug TargetingCardiovascular diseases (CVDs) are the leading cause of death globally, with oxidative stress (OS) identified as a primary contributor to their onset and progression. Given the elevated incidence and mortality rates associated with CVDs, there is an imperative need to investigate novel therapeutic strategies. Nuclear factor erythroid 2-related factor 2
Qi, Wu +5 more
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The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer
Antioxidants & Redox Signaling, 2010The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight regulation is crucial to maintain cellular homeostasis. Activation of this pathway is important in preventing human diseases, such as cancer, neurodegenerative disease,
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The Nrf2-Keap1 pathway is activated by steroid hormone signaling to govern neuronal remodeling
Cell Reports, 2021Fengwei Yu
exaly
New insights into the role of the Nrf2 signaling pathway in green tea catechin applications
Phytotherapy Research, 2021Marjan Talebi +2 more
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Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease
Biomedicine and Pharmacotherapy, 2023Jianzheng
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