Results 271 to 280 of about 112,785 (303)

The Effects of Ginsenosides on the Nrf2 Signaling Pathway

2021
Nuclear factor erythroid-2 related factor 2 (Nrf2) is a major signaling pathway for the maintenance of homeostasis and redox balance. This pathway also plays a significant role in proteostasis, xenobiotic/drug metabolism, apoptosis, and lipid and carbohydrate metabolism.
Ashrafizadeh, Milad, Ahmadi, Zahra, Yaribeygi, Habib, Sathyapalan, Thozhukat, Jamialahmadi, Tannaz, Sahebkar, Amirhossein   +5 more
openaire   +3 more sources

Mangiferin alleviates hyperglycemia-induced endothelial impairment via Nrf2 signaling pathway

European Journal of Pharmacology, 2022
The regulation of angiogenesis by nuclear factor erythroid 2-related factor 2 (Nrf2), a master redox transcription factor, is well established. In the present study, we aimed to activate Nrf2 by mangiferin (MG) and investigate its potential to regulate angiogenesis under a hyperglycemic (HG) environment in human endothelial cells.
Ravichandran Jayasuriya, Kunka Mohanram Ramkumar   +1 more
openaire   +2 more sources

The Study of Nrf2 Signaling Pathway in Ovarian Cancer

Critical Reviews in Eukaryotic Gene Expression, 2018
Ovarian cancer is one of the most malignant gynecological tumors in the world, with a high fatality rate and resistance to chemotherapy. Much basic research has revealed that oxidative stress is involved in tumor occurrence and development processes and is associated with tumor progression as well as metastasis.
Xiaotong, Wu, Li Ying, Han, Xiao Xiao, Zhang, Ling, Wang   +3 more
openaire   +2 more sources

Theaflavins alleviate sevoflurane-induced neurocytotoxicity via Nrf2 signaling pathway

International Journal of Neuroscience, 2019
Aim: Sevoflurane could induce apoptosis of rat hippocampal neurons, while theaflavins (TFs) have antioxidant and anti-inflammatory properties. This study aims to explore whether TFs could alleviate sevoflurane-induced neuronal cell injury.Materials and methods: Cells were treated by concentration gradient of sevoflurane and TFs.
Rongsheng, Zhou, Xiaogang, Li, Lu, Li, Han, Zhang   +3 more
openaire   +2 more sources

The Keap1-Nrf2 Signaling Pathway in Lung Cancer

2021
The survival and proliferation of lung cancers widely depend on various signaling pathways; Keap1-Nrf2-ARE is one of the primary pathways in lung cancers. The principal function of Nrf2 is to offer protection to cells from stress induced by xenobiotics through the activation of cytoprotective transcriptional programs.
Azhwar Raghunath, Raju Nagarajan, Kiruthika Sundarraj   +2 more
openaire   +1 more source

Quercetin alleviates hyperthyroidism‐induced liver damage via Nrf2 Signaling pathway

BioFactors, 2020
AbstractQuercetin is a plant flavonoid and has antioxidative properties. In this study, we evaluated the therapeutic effect of quercetin on thyroid dysfunction in L‐thyroxin (LT4)‐induced hyperthyroidism rats. LT4 was used to prepare the experimental hyperthyroidism model via the intraperitoneal injection.
Pengxin Zhao, Zhigang Hu, Weiyuan Ma, Leilei Zang, Zhisheng Tian, Qian Hou   +5 more
openaire   +2 more sources

Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway

The International Journal of Biochemistry & Cell Biology, 2006
In the broadest sense, cellular stress describes conditions wherein cells encounter and react to a 'non-normal' state. Perturbations may originate through both extracellular and intracellular means. Whereas transient levels of stress are expected to occur on a regular basis, a series of checks and balances ensures that cells are well equipped to ...
Sara B, Cullinan, J Alan, Diehl
openaire   +2 more sources

Quercetin's Neuroprotective Role: Activating Nrf2 Signaling Pathways

Current Nutrition & Food Science
With the global elderly population projected to double by 2050, there is an increasing need to address the risk factors associated with neurodegenerative diseases. This article focuses on exploring the potential neuroprotective effects of quercetin mediated through the Nrf2 signaling pathway.
Farbod Hatami, Tahereh Farkhondeh, Alia Mohaqeq, Niloufar Valizadeh, Michael Aschner, Effat Alemzadeh, Saeed Samarghandian   +6 more
openaire   +1 more source

Atractylenolide II prevents radiation damage via MAPKp38/Nrf2 signaling pathway

Biochemical Pharmacology, 2020
Ionizing radiation (IR) can act as a negative factor for human homeostasis, by causing and even aggravating a series of pathological conditions. To protect the intactness of normal tissues, effective anti-radiation drugs are urgently needed for alleviating the outcomes of radioactive damage. In this study, we demonstrate that atractylenolide II (ATR II)
Changyan, Xiao, Chang, Xu, Ningning, He, Yang, Liu, Yan, Wang, Manman, Zhang, Kaihua, Ji, Liqing, Du, Jinhan, Wang, Qin, Wang, Qiang, Liu   +10 more
openaire   +2 more sources

Triptolide activates the Nrf2 signaling pathway and inhibits the NF-κB signaling pathway to improve Alzheimer disease

Metabolic Brain Disease, 2023
Alzheimer disease (AD) is a common neurodegenerative disease with pathological features of accumulated amyloid plaques, neurofibrillary tangles, and the significant inflammatory environment. These features modify the living microenvironment for nerve cells, causing the damage, dysfunction, and death.
Zuoting He, Benson O.A. Botchway, Yong Zhang, Xuehong Liu   +3 more
openaire   +2 more sources