Results 201 to 210 of about 25,630 (256)

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

Detection of disk-jet coprecession in a tidal disruption event. [PDF]

Sci Adv
Wang Y, Lin Z, Wu L, Lei WH, Wei S, Zhang SN, Ji L, Del Palacio S, Baldi RD, Huang Y, Liu JF, Zhang B, Yang A, Chen RR, Zhang Y, Wang AL, Yang L, Charalampopoulos P, Williams-Baldwin DRA, Yao ZH, Xie FG, Bu D, Feng H, Cao X, Wu H, Li W, Qiao E, Leloudas G, Anderson JP, Shu X, Pasham DR, Zou H, Nicholl M, Wevers T, Müller-Bravo TE, Wang J, Wei JY, Qiu YL, Guo WJ, Gutiérrez CP, Gromadzki M, Inserra C, Makrygianni L, Onori F, Petrushevska T, Altamirano D, Galbany L, Peréz-Torres M, Chen TW.   +48 more
europepmc   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Self-Assembled Monolayer Anode Enables 7% Efficiency in Y6-Based Quasi-Homojunction Solar Cells With 4% Donor Contents. [PDF]

Small Sci
Suen MH, Zhang Z, An Y, Du P, Wang Y, Tang Y, Zhang C, Wang S, Liu T, Ouyang S, Cai G, Lu G, Yip HL, Tsang SW, So SK.   +14 more
europepmc   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Enabling highly efficient infrared silicon photodetectors via disordered metasurfaces with upconversion nanoparticles. [PDF]

Sci Adv
Chen W, Zhang S, Wang C, Wu Y, Shi X, Shen J, Liu Y, Zhang X, Tjiptoharsono F, Lee HYL, Zhu D, Wang Q, Yang JKW, Zhu J, Dong Z.   +14 more
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Inducing and monitoring photothrombotic stroke in anesthetic neuroprotection-free mice using functional photoacoustic microscopy. [PDF]

Neurophotonics
Li C, Chen K, Cai H, Hong X, Chen J.
europepmc   +1 more source

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

Engineering topological chiral transport in a flat-band lattice of ultracold atoms. [PDF]

Light Sci Appl
Li H, Liang Q, Dong Z, Wang H, Yi W, Pan JS, Yan B.   +6 more
europepmc   +1 more source