Results 181 to 190 of about 29,671 (305)

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

A two-species competition model on a compact metric graph for the invasion and competition of Aedes Aegypti and Aedes Albopictus mosquitoes in Florida. [PDF]

J Math Biol
Tian C, Zou L, Ruan S.
europepmc   +1 more source

Learning to Win in Evolutionary Two-person Boolean Game with Fixed Strategy Updating Rule**This work was partially supported by the National Natural Science Foundation in China (NSFC) under Grant 61473038.

IFAC-PapersOnLine, 2015
Dong WANG, MA Hongbin
openaire   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

A monocyte-centered framework for predicting immunochemotherapy efficacy in lung squamous cell carcinoma patients. [PDF]

EMBO Mol Med
Zhao J, Wang Z, Xiao M, Zhang Y, Liu B, Chen S, Tian Y, Lv D, Wang P, Song H, Wu Y, Liu J, Wang K.   +12 more
europepmc   +1 more source

Model-free Adaptive Control for a Vapour-Compression Refrigeration Benchmark Process ⁎ ⁎This work is supported by National Natural Science Foundation of China (NSFC) under Grants 61433002 and 61403025, and by Beijing Natural Science Foundation under Grant L161007 (Corresponding author: Zhongsheng Hou).

IFAC-PapersOnLine, 2018
Xian Yu, Zhongsheng Hou, Xin Zhang
openaire   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Quantum algorithms for viscosity solutions to nonlinear Hamilton-Jacobi equations based on an entropy penalization method. [PDF]

Proc Natl Acad Sci U S A
Jin S, Liu N.
europepmc   +1 more source

Prediction of Protein-RNA Interactions Using Sequence and Structure Descriptors**This work was partially supported by the National Natural Science Foundation of China (NSFC) Grant No. 31100949, the Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education of China, the Fundamental Research Funds of Shandong University Grant No. 2014TB006, University of Rochester Center for AIDS Research Grant P30 AI078498 (NIH/NIAID) and NIH R01 Grant GM100788-01.

IFAC-PapersOnLine, 2015
Zhi-Ping Liu, Hongyu Miao
openaire   +1 more source

A Whole‐Head Finite Element Model for Electrical Neuromodulation via Visual Brain‐Machine Interfaces

Advanced Science, EarlyView.
A multimodal, personalized head model is presented that integrates the entire visual pathway with surrounding tissues to simulate electrical stimulation of the optic nerve. In vivo validation in humans and goats, plus systematic component‐elimination analysis, demonstrates the high accuracy of the comprehensive model.
Shengjian Lu, Tonghe Yang, Yuan Geng, Huan Wu, Yangrui Huang, Te Zheng, Haodi Chen, Shurui Huang, Yi Cao, Jian Yang, Wentao Yan, Yikui Zhang, Wencan Wu   +12 more
wiley   +1 more source