Results 191 to 200 of about 25,630 (256)

Unconventional-Phase 1T'-Transition Metal Dichalcogenide Monolayers Grown on Amorphous Templates for Highly Efficient Hydrogen Evolution. [PDF]

J Am Chem Soc
Li Z, Yang H, Sun M, Zhang A, Ge Y, Long X, Huang B, Zhai L, Zhai W, Li L, Wang L, Wang C, Xu Y, Cai Y, Liu P, Chen B, Gu L, Qiao P, Zhang Q, Ding F, Zhang H.   +20 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Controlling transient and coupled diffusion with pseudoconformal mapping. [PDF]

Proc Natl Acad Sci U S A
Dai G, Qu T, Lei M, Li Z, Yang F, Zhang Z, Wang Y, Xie H, Huang J, Wang J.   +9 more
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Exploration and Practice of the First Clinical Medical Postdoctoral Program in China: Retrospective, Nonrandomized, Controlled Study.

JMIR Med Educ
Zhang L, Sun L, Li H.
europepmc   +1 more source

Transcriptional condensates encode a "golden mean" to optimize enhancer-promoter communication across genomic distances. [PDF]

Proc Natl Acad Sci U S A
Zhu T, Li C, Chu X.
europepmc   +1 more source

Ga Doping Enables Precision Alloy‐to‐Wire Regulation: Synergistic Enhancement of the Mechanical Properties of CuSn Alloy and the Superconducting Properties of Nb3Sn

Advanced Science, EarlyView.
By adjusting Ga's doping in Cu–Sn alloy, an ultra‐high elongation of 100.8% is achieved in first time. Ga forms a stable solid solution structure and a stronger electron exchange with Cu. This enhances strength‐ductility synergistically by tuning SFE to balance twinning and slip.
Dazhuo Song, Juntao Zou, Jiayue Zhang, Xinhang Liang, Mengyu Shan, Yifan Liu, Jingqi Feng, Tong Dang, Lin Shi, Yuxuan Wang, Yuchen Song, Rong Fei, Shaodong Sun, Zhe Zhang, Lei Zhu, Lixing Sun   +15 more
wiley   +1 more source

Theta-nested gamma oscillations balance prediction and vigilance in spatial navigation. [PDF]

Proc Natl Acad Sci U S A
Li KT, Wang Z, Gong P, Yang D.
europepmc   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Twisted bilayer Ice as a new class of hydrogen-bonding moiré materials. [PDF]

Nat Commun
Wang L, Jiang J, Liu S, Lin S, Yan J, Zhu Y, Xia J, Wang R, Wang C, Tang C, Zeng XC.   +10 more
europepmc   +1 more source