Results 1 to 10 of about 12,023 (208)

NTRK1 Fusion in Glioblastoma Multiforme [PDF]

PLoS ONE, 2014
Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor, yet with no targeted therapy with substantial survival benefit. Recent studies on solid tumors showed that fusion genes often play driver roles and are promising targets for ...
Jinkuk Kim, Young-Hyeh Ko, Kyeung Min Joo   +2 more
exaly   +5 more sources

Novel NOTCH2-NTRK1 fusion confers osimertinib resistance in EGFR-mutant non-small cell lung cancer by interacting with EGFR [PDF]

Translational Oncology
Background: Overcoming osimertinib resistance in epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) is challenging due to unclear mechanisms. We previously reported a NSCLC case with EGFR mutations progressed on osimertinib
Hui Li, Huiting Wei, Tiantian Zhen, Huabin Gao, Huicong Liu, Shuai Zheng, Huijuan Shi, Jiangtao Liang, Fenfen Zhang, Jiecheng Ye, Gengpeng Lin, Anjia Han   +11 more
doaj   +2 more sources

Case Report: Novel findings of larotrectinib in children with NTRK-rearranged spindle cell tumor [PDF]

Frontiers in Oncology
Neurotrophic tropomyosin receptor kinase (NTRK)-rearranged spindle cell tumors are often resistant to chemotherapy and radiotherapy. Fortunately, they are sensitive to targeted therapy of tropomyosin receptor kinase (TRK) inhibitors. However, the data on
Linnan Wu, Linnan Wu, Weiji Xie, Weiji Xie, Juan Wang, Juan Wang, Suying Lu, Suying Lu, Yizhuo Zhang, Yizhuo Zhang, Junting Huang, Junting Huang   +11 more
doaj   +2 more sources

Fusion-Negative NTRK Overexpression Exhibit Biological Relevance in Colorectal Cancer: Implications for Prediction of Responses to Kinase Inhibitors [PDF]

Pharmaceuticals
Background/Objectives: The aims of this study are to define the roles of the neurotrophic tyrosine receptor kinase genes NTRK1, NTRK2 and NTRK3 (NTRK1/2/3) in CRC and to determine the clinicopathological, molecular, cancer signalling and potential ...
Abdulaziz Alfahed
doaj   +2 more sources

Unidirectional Crosstalk Between NTRK1 and IGF2 Drives ER Stress in Chronic Pain [PDF]

Biomedicines
Background: Chronic postsurgical pain (CPSP) poses a major clinical challenge due to unresolved links between neurotrophic pathways and endoplasmic reticulum (ER) stress.
Caixia Zhang, Kaiwen Zhang, Wencui Zhang, Bo Jiao, Xueqin Cao, Shangchen Yu, Mi Zhang, Xianwei Zhang   +7 more
doaj   +2 more sources

LMNA-NTRK1-rearranged spindle cell neoplasm with multiple relapses: a case report and literature review [PDF]

Frontiers in Medicine
Neurotrophic tyrosine receptor kinase (NTRK)-rearranged spindle cell neoplasms (NTRK-RSCNs) constitute a rare, heterogeneous subset of soft tissue tumors defined by oncogenic fusions involving NTRK1, NTRK2, or NTRK3 genes. Despite the remarkable efficacy
Yinan Zhu, Ziyue Wang, Haiyan Xi, Wanchen Lu, Mingfang Sun, Xuyong Lin   +5 more
doaj   +2 more sources

NTRK1-rearranged histiocytosis: clinicopathologic and molecular features. [PDF]

Blood Adv
Abstract Non-Langerhans cell histiocytoses are a diverse group of histiocytic diseases. Different entities are defined based on clinical, histopathologic, and/or molecular characteristics. This study aimed to define NTRK-rearranged histiocytosis.
Fragneau R, Fraitag S, Kemps PG, Hélias-Rodzewicz Z, Roy S, Bonsang B, Bartlett AL, Dhar S, Jankofsky M, Zlocha J, Svojgr K, Krsková L, de Vries ACH, Verdijk RM, van Laar JAM, Leguit RJ, Drabent P, Carlsen ED, Ho J, Karunamurthy AD, Santi M, Jullié ML, Babor F, Lorsbach R, van Halteren AGS, Héritier S, Diamond EL, Durham BH, Kumar AR, Bhattacharya A, Haroche J, Donadieu J, Borkhardt A, Picarsic JL, Emile JF.   +34 more
europepmc   +4 more sources

Rearrangements of NTRK1 gene in papillary thyroid carcinoma [PDF]

Molecular and Cellular Endocrinology, 2010
TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3' terminal sequences of the NTRK1/NGF receptor gene with 5' terminal sequences of various activating genes, such as TPM3, TPR and TFG.
Angela Greco
exaly   +3 more sources

NTRK-rearranged spindle cell neoplasm of the female genital tract: case report and literature review [PDF]

Frontiers in Oncology
NTRK-rearranged spindle cell neoplasm is a rare subtype of soft tissue sarcoma that occasionally arises in the lower female genital tract. Accurate diagnosis is clinically important, as these tumors generally display low-grade malignant behavior and may ...
Lulu Feng, Lulu Feng, Lei Li, Lei Li, Yanmei He, Yanmei He, Wei Jiang, Wei Jiang   +7 more
doaj   +2 more sources

Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer [PDF]

Nature Medicine, 2013
We identified new gene fusions in patients with lung cancer harboring the kinase domain of the NTRK1 gene that encodes the high-affinity nerve growth factor receptor (TRKA protein). Both the MPRIP-NTRK1 and CD74-NTRK1 fusions lead to constitutive TRKA kinase activity and are oncogenic. Treatment of cells expressing NTRK1 fusions with inhibitors of TRKA
Aria Vaishnavi, Marzia Capelletti, Anh T Le   +2 more
exaly   +3 more sources