Results 11 to 20 of about 12,023 (208)
Utility of a commercial antibody against NTRK1 for western blotting and potential application to immunohistochemistry in adult mouse brain [PDF]
Scientific ReportsNtrk1 (also known as TrkA) is a nerve growth factor receptor with essential roles in the development and function of the cholinergic nervous system. Ntrk1 is expressed in a few specific and defined brain areas.
Kazuo Nakajima +2 more
doaj +2 more sources
NTRK1 Gene Fusions Are Frequent in Juvenile Xanthogranuloma. [PDF]
Am J Surg PatholJuvenile Xanthogranuloma (JXG) is a rare form of non-Langerhans cell histiocytosis. The most common known gene mutations affect the mitogen-activated protein (MAP) kinase, phosphoinositide 3-kinase (PI3K), and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathways.
Schlögl E +10 more
europepmc +3 more sources
Nature Communications, 2017 The use of mouse models has been an invaluable resource in cancer research but their generation is lengthy and costly. Here the authors describe an approach to generate engineered mouse models carrying specific gene fusions and, as a proof of principle ...
Peter J Cook +2 more
exaly +2 more sources
Transcriptomics reveals the effects of NTRK1 on endoplasmic reticulum stress response-associated genes in human neuronal cell lines [PDF]
PeerJ, 2023 Background NTRK1 gene, encoding TrkA, is essential for the nervous system and drives a variety of biological processes, including pain. Given the unsatisfied analgesic effects of some new drugs targeting NTRK1 in clinic, a deeper understanding for the ...
Bo Jiao +7 more
doaj +2 more sources
Ameloblastic Fibrosarcoma of the Jaw: Case Report, Genetic Profiling, and Literature Review
Case Reports in Oncology, 2023 Ameloblastic fibrosarcoma (AFS) is considered a malignant progression resulting from dysplastic changes in an ameloblastic fibroma (AF). Both tumors are extremely rare, with only a few cases reported in the scientific literature.
Duna Barakeh +2 more
doaj +1 more source
The discovery of hidden guanylate cyclases (GCs) in the Homo sapiens proteome
Computational and Structural Biotechnology Journal, 2023 Recent discoveries have established functional guanylate cyclase (GC) catalytic centers with low activity within kinase domains in plants. These crypto GCs generate guanosine 3’,5’-cyclic monophosphate (cGMP) essential for both intramolecular and ...
Ilona Turek +7 more
doaj +1 more source
Cell Death Discovery, 2023 Hippocampal neuronal damage may induce cognitive impairment. Neurotrophic tyrosine kinase receptor 1 (NTRK1) reportedly regulates neuronal damage, although the underlying mechanism remains unclear. The present study aimed to investigate the role of NTRK1
Kai Yang +14 more
doaj +1 more source
BMC Nephrology, 2022 Background Mesangial proliferative glomerulonephritis (MsPGN) accounts for a main cause of chronic kidney disease (CKD), chronic renal failure and uremia.
Xiongjun Dong, Yingchun Tang
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Identification of NTRK gene fusions in lung adenocarcinomas in the Chinese population
The Journal of Pathology: Clinical Research, 2021 The molecular profile of neurotrophic tyrosine kinase receptor (NTRK) gene fusions in lung adenocarcinoma (LUAD) is not fully understood. Next‐generation sequencing (NGS) and pan‐tyrosine kinase receptor (TRK) immunohistochemistry (IHC) are powerful ...
Ruiying Zhao +11 more
doaj +1 more source
Clinicopathological findings of pediatric NTRK fusion mesenchymal tumors
Diagnostic Pathology, 2020 Background While ETV6- NTRK3 fusion is common in infantile fibrosarcoma, NTRK1/3 fusion in pediatric tumors is scarce and, consequently, not well known.
Jeongwan Kang +12 more
doaj +1 more source