Results 31 to 40 of about 26,611 (238)
Preparation of the Human Cytomegalovirus Nuclear Egress Complex and Associated Proteins. [PDF]
Methods Enzymol, 2016 Herpesviruses, like most DNA viruses, replicate their genomes in the host cell nucleus. Their DNA is then packaged and assembled into viral nucleocapsids, which, in most cases, are too large to pass through the nuclear pore complex. Instead, herpesviruses use a complex multistep pathway, termed nuclear egress, to exit the nucleus.
Sharma M, Kamil JP, Coen DM.
europepmc +4 more sources
Structural basis of membrane budding by the nuclear egress complex of herpesviruses. [PDF]
EMBO J, 2015 AbstractDuring nuclear egress, herpesvirus capsids bud at the inner nuclear membrane forming perinuclear viral particles that subsequently fuse with the outer nuclear membrane, releasing capsids into the cytoplasm. This unusual budding process is mediated by the nuclear egress complex (NEC) composed of two conserved viral proteins, UL31 and UL34 ...
Bigalke JM, Heldwein EE.
europepmc +3 more sources
Host and Viral Factors Involved in Nuclear Egress of Herpes Simplex Virus 1
Viruses, 2021 Herpes simplex virus 1 (HSV-1) replicates its genome and packages it into capsids within the nucleus. HSV-1 has evolved a complex mechanism of nuclear egress whereby nascent capsids bud on the inner nuclear membrane to form perinuclear virions that ...
Jun Arii
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Membrane deformation and scission by the HSV-1 nuclear egress complex. [PDF]
Nat Commun, 2014 The nuclear egress complex (NEC) of herpesviruses such as HSV-1 is essential for the exit of nascent capsids from the cell nucleus. The NEC drives nuclear envelope vesiculation in cells, but the precise budding mechanism and the potential involvement of cellular proteins are unclear.
Bigalke JM +3 more
europepmc +4 more sources
Viruses, 2021 The molecular mechanism affecting translocation of newly synthesized herpesvirus nucleocapsids from the nucleus into the cytoplasm is still not fully understood.
Anna D. Dorsch +5 more
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Structural Basis for Capsid Recruitment and Coat Formation during HSV-1 Nuclear Egress
Proceedings, 2020 During herpesvirus infection, nascent viral capsids egress the nucleus into the cytoplasm by an unusual mechanism whereby capsids bud at the inner nuclear membrane.
Elizabeth Draganova +3 more
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The role of clathrin in post-golgi trafficking in toxoplasma gondii [PDF]
, 2013 Apicomplexan parasites are single eukaryotic cells with a highly polarised secretory system that contains unique secretory organelles (micronemes and rhoptries) that are required for host cell invasion.
Ferguson, D.J.P. +3 more
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Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex. [PDF]
EMBO J, 2015 AbstractHerpesvirus nucleocapsids escape from the nucleus in a process orchestrated by a highly conserved, viral nuclear egress complex. In human cytomegalovirus, the complex consists of two proteins, UL50 and UL53. We solved structures of versions of UL53 and the complex by X‐ray crystallography.
Lye MF +6 more
europepmc +4 more sources
Cells, 2022 Herpesviral nuclear egress is a fine-tuned regulatory process that defines the nucleocytoplasmic release of viral capsids. Nuclear capsids are unable to traverse via nuclear pores due to the fact of their large size; therefore, herpesviruses evolved to ...
Sigrun Häge, Manfred Marschall
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AbstractHerpesvirus capsids must exit the nucleus to undergo additional maturation steps in the cytoplasm, such as secondary envelopment. This process is orchestrated by the nuclear egress complex (NEC), a conserved heterodimer that deforms the inner nuclear membrane and facilitates capsid egress.
Sanders S +8 more
europepmc +2 more sources