Results 91 to 100 of about 7,287 (212)

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley   +1 more source

Caveolin‐1 enriched apoptotic bodies derived from oral hard palate orchestrate bone remodeling to treat heterotopic ossification

BMEMat, EarlyView.
Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang, Like Tang, Zhou Yu, Wenjin Cai, Qifeng Jiang, Zhikang Wang, Yitong Chen, Kaichen Lai, Ying Wang, Tim Forouzanfar, Chiyuan Ma, Gang Wu, Tingben Huang, Guoli Yang   +13 more
wiley   +1 more source

A new function for nuclear lamins: providing surface tension to the nuclear drop. [PDF]

Curr Opin Biomed Eng, 2023
Dickinson RB, Lele TP.
europepmc   +1 more source

Hepatocyte-Specific Deletion of Mouse Lamin A/C Leads to Male-Selective SteatohepatitisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Lamins are nuclear intermediate filament proteins that comprise the major components of the nuclear lamina. Mutations in LMNA, which encodes lamins A/C, cause laminopathies, including lipodystrophy, cardiomyopathy, and premature aging
Raymond Kwan, Graham F. Brady, Maria Brzozowski, Sujith V. Weerasinghe, Hope Martin, Min-Jung Park, Makayla J. Brunt, Ram K. Menon, Xin Tong, Lei Yin, Colin L. Stewart, M. Bishr Omary   +11 more
doaj   +1 more source

Interdependent changes of nuclear lamins, nuclear pore complexes, and ploidy regulate cellular regeneration and stress response in the heart. [PDF]

Nucleus, 2023
Li Y, Bertozzi A, Mann MR, Kühn B.
europepmc   +1 more source

Materials and Music: Selective Imperfection as a Generative Framework for Analysis, Creativity and Discovery

Interdisciplinary Materials, EarlyView.
Vibrations in matter, from spider webs to molecules, water to flames, share a grammar with music. We propose that creativity emerges when constraints force expansion beyond existing possibilities. Selective imperfection restores balance, enabling invention.
Markus J. Buehler
wiley   +1 more source

Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies

Cells, 2016
Lamins are mechanosensitive and elastic components of the nuclear lamina that respond to external mechanical cues by altering gene regulation in a feedback mechanism.
Subarna Dutta, Maitree Bhattacharyya, Kaushik Sengupta   +2 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Kaempferol Attenuates Myocardial Ischemia–Reperfusion Injury by Suppressing Ferroptosis via the KEAP1–Nrf2–GPX4 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao, Ling‐Ling Sun, Xiao‐Hua Shen, Min Wang, Mei‐Hui Wang, Lu‐Lu Liu, Kai Zhang   +6 more
wiley   +1 more source

Robert Feulgen Lecture | LAMINS IN NUCLEAR ORGANISATION AND CHROMATIN REGULATION

European Journal of Histochemistry
Lamins form a filamentous network at the nuclear envelope that anchors heterochromatin and repressed genes to the nuclear periphery. Lamin A also exists as a non-filamentous pool in the nuclear interior, where it interacts with lamin-associated ...
doaj   +1 more source