Sequence specificity of an essential nuclear localization sequence in Mcm3. [PDF]
PLoS GeneticsProteins with nuclear localization sequences (NLSs) are directed into the cell nucleus through interactions between the NLS and importin proteins. NLSs are generally short motifs rich in basic amino acids; however, identifying NLSs can be challenging due
Ziyi Wang +6 more
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Investigation of PLGA nanoparticles in conjunction with nuclear localization sequence for enhanced delivery of antimiR phosphorothioates in cancer cells in vitro [PDF]
Journal of Nanobiotechnology, 2019 Numerous first generation phosphorothioates (PS) and their derivatives have shown promise targeting mRNA for therapeutic applications and also gained market approval for their use as a drug.
Shipra Malik, Raman Bahal
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Nuclear Import of Arabidopsis Poly(ADP-Ribose) Polymerase 2 Is Mediated by Importin-α and a Nuclear Localization Sequence Located Between the Predicted SAP Domains [PDF]
Frontiers in Plant Science, 2018 Proteins of the Poly(ADP-Ribose) Polymerase (PARP) family modify target proteins by covalent attachment of ADP-ribose moieties onto amino acid side chains.
Chao Chen +3 more
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The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure [PDF]
Nature Communications, 2020 Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) shuttles between the nucleus and cytoplasm to regulate gene expression and RNA metabolism and its low complexity (LC) C-terminal domain facilitates liquid–liquid phase separation and amyloid ...
Yunpeng Sun +12 more
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Nuclear Trafficking of the Rabies Virus Interferon Antagonist P-Protein Is Regulated by an Importin-Binding Nuclear Localization Sequence in the C-Terminal Domain. [PDF]
PLoS One, 2016 Rabies virus P-protein is expressed as five isoforms (P1-P5) which undergo nucleocytoplasmic trafficking important to roles in immune evasion. Although nuclear import of P3 is known to be mediated by an importin (IMP)-recognised nuclear localization ...
Rowe CL +5 more
europepmc +4 more sources
A monopartite nuclear localization sequence regulates nuclear targeting of the actin binding protein myopodin [PDF]
FEBS Letters, 2005 Myopodin is an actin bundling protein that shuttles between nucleus and cytoplasm in response to cell stress or during differentiation. Here, we show that the myopodin sequence (58)KKRRRRARK(66), when tagged to either enhanced green fluorescent protein ...
Ariane De Ganck +6 more
core +7 more sources
Identification and characterization of a nuclear localization sequence-binding protein in yeast. [PDF]
Proceedings of the National Academy of Sciences, 1989 Nuclear proteins contain specific regions that are required for entry into the nucleus. Using ligand blotting, we have shown that a 67-kDa yeast nuclear envelope protein (p67) recognizes synthetic peptides containing the yeast histone H2B or simian virus
W C Lee, T Mélèse
semanticscholar +6 more sources
Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation. [PDF]
Biochemistry, 2018 TAR DNA-binding protein of 43 kDa (TDP-43) forms granulo-filamentous aggregates in affected brain regions of >95% of patients with ALS and ∼50% of patients with frontotemporal degeneration (FTD).
McGurk L +4 more
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Platinum (II) complex-nuclear localization sequence peptide hybrid for overcoming platinum resistance in cancer therapy. [PDF]
ACS Biomater Sci Eng, 2018 Platinum therapy represents first line of treatment in many malignancies but its high systemic toxicity limits the therapeutic dosage. Herein, we report the synthesis of carboplatin-like complexes with azide and alkyne functional groups and the formation
Wlodarczyk MT +6 more
europepmc +2 more sources
Bioinformatics and Functional Analysis of a New Nuclear Localization Sequence of the Influenza A Virus Nucleoprotein [PDF]
Cells, 2022 Influenza viruses deliver their genome into the nucleus of infected cells for replication. This process is mediated by the viral nucleoprotein (NP), which contains two nuclear localization sequences (NLSs): NLS1 at the N-terminus and a recently ...
Nhan L. T. Nguyen, Nelly Panté
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