Sequence specificity of an essential nuclear localization sequence in Mcm3. [PDF]
PLoS GeneticsProteins with nuclear localization sequences (NLSs) are directed into the cell nucleus through interactions between the NLS and importin proteins. NLSs are generally short motifs rich in basic amino acids; however, identifying NLSs can be challenging due
Ziyi Wang +6 more
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Bioinformatics and Functional Analysis of a New Nuclear Localization Sequence of the Influenza A Virus Nucleoprotein [PDF]
Cells, 2022 Influenza viruses deliver their genome into the nucleus of infected cells for replication. This process is mediated by the viral nucleoprotein (NP), which contains two nuclear localization sequences (NLSs): NLS1 at the N-terminus and a recently ...
Nhan L. T. Nguyen, Nelly Panté
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Investigation of PLGA nanoparticles in conjunction with nuclear localization sequence for enhanced delivery of antimiR phosphorothioates in cancer cells in vitro [PDF]
Journal of Nanobiotechnology, 2019 Numerous first generation phosphorothioates (PS) and their derivatives have shown promise targeting mRNA for therapeutic applications and also gained market approval for their use as a drug.
Shipra Malik, Raman Bahal
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Localization of Daucus carota NMCP1 to the nuclear periphery: the role of the N-terminal region and an NLS-linked sequence motif, RYNLRR, in the tail domain [PDF]
Frontiers in Plant Science, 2014 Recent ultrastructural studies revealed that a structure similar to the vertebrate nuclear lamina exists in the nuclei of higher plants. However, plant genomes lack genes for lamins and intermediate-type filament proteins, and this suggests that plant ...
Yuta eKimura +3 more
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Unraveling the Nuclear Localization Sequence of MoHTR2, the Nuclear Effector of Magnaporthe oryzae [PDF]
The Plant Pathology JournalPlant pathogenic fungi modulate host immunity by secreting nuclear effectors that interact with host nucleic acids and proteins within the host nucleus. Nuclear effectors are widely known to possess a nuclear localization sequence (NLS) that allows them ...
Jiwon Choi, You-Jin Lim, Yong-Hwan Lee
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Nuclear Import of Arabidopsis Poly(ADP-Ribose) Polymerase 2 Is Mediated by Importin-α and a Nuclear Localization Sequence Located Between the Predicted SAP Domains [PDF]
Frontiers in Plant Science, 2018 Proteins of the Poly(ADP-Ribose) Polymerase (PARP) family modify target proteins by covalent attachment of ADP-ribose moieties onto amino acid side chains.
Chao Chen +3 more
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Deciphering the Binding of the Nuclear Localization Sequence of Myc Protein to the Nuclear Carrier Importin α3. [PDF]
Int J Mol Sci, 2022 Rizzuti B, Iovanna JL, Neira JL.
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The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure [PDF]
Nature Communications, 2020 Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) shuttles between the nucleus and cytoplasm to regulate gene expression and RNA metabolism and its low complexity (LC) C-terminal domain facilitates liquid–liquid phase separation and amyloid ...
Yunpeng Sun +12 more
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Engineering, 2015 The emergence of multidrug-resistant bacteria creates an urgent need for alternative antibiotics with new mechanisms of action. In this study, we synthesized a novel type of antimicrobial agent, Acr3-NLS, by conjugating hydrophobic acridines to the N ...
Wei Zhang +7 more
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Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells. [PDF]
Cells, 2022 Lampart A +6 more
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