Bioinformatics and Functional Analysis of a New Nuclear Localization Sequence of the Influenza A Virus Nucleoprotein [PDF]
Cells, 2022 Influenza viruses deliver their genome into the nucleus of infected cells for replication. This process is mediated by the viral nucleoprotein (NP), which contains two nuclear localization sequences (NLSs): NLS1 at the N-terminus and a recently ...
Nhan L. T. Nguyen, Nelly Panté
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Cellular Import Mediated by Nuclear Localization Signal Peptide Sequences [PDF]
Chemistry & Biology, 2002 The cellular delivery of therapeutic agents and their localization within cells is currently a great challenge in medicinal chemistry. A few cationic peptides have shown a strong propensity to cross the cytoplasmic membrane and enter cells. Nuclear localization signal (NLS) sequences are a class of highly cationic peptides that may be exploited for ...
Angela D. Ragin +2 more
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Rules for Nuclear Localization Sequence Recognition by Karyopherinβ2 [PDF]
Cell, 2006 Karyopherinbeta (Kapbeta) proteins bind nuclear localization and export signals (NLSs and NESs) to mediate nucleocytoplasmic trafficking, a process regulated by Ran GTPase through its nucleotide cycle. Diversity and complexity of signals recognized by Kap betas have prevented prediction of new Kap beta substrates.
Brittany J. Lee +5 more
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The role of IFNγ nuclear localization sequence in intracellular function [PDF]
Journal of Cell Science, 2003 Intracellularly expressed interferon γ (IFNγ) has been reported to possess biological activity similar to that of IFNγ added to cells. This study addresses the mechanisms for such similar biological effects. Adenoviral vectors were used to express a non-secreted form of human IFNγ or a non-secreted mutant form in which a previously demonstrated nuclear
C. M. Iqbal Ahmed +4 more
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Multiple nuclear localization sequences in SRSF4 protein [PDF]
Genes to Cells, 2020 AbstractSRSF4 is one of the members of serine‐/arginine (SR)‐rich protein family involved in both constitutive and alternative splicing. SRSF4 is localized in the nucleus with speckled pattern, but its nuclear localization signal was not determined. Here, we have identified nuclear localization signals (NLSs) of SRSF4 by using a pyruvate kinase fusion ...
So Masaki +3 more
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Deletion of the nuclear localization sequence and C-terminus of parathyroid hormone–related protein decreases osteogenesis and chondrogenesis but increases adipogenesis and myogenesis in murine bone marrow stromal cells [PDF]
Journal of Tissue Engineering, 2015 The N-terminus of parathyroid hormone–related protein regulates bone marrow stromal cell differentiation. We hypothesized that the nuclear localization sequence and C-terminus are involved.
Blake E Hildreth +7 more
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Amino acid sequences that determine the nuclear localization of yeast histone 2B. [PDF]
Molecular and Cellular Biology, 1987 Histone-beta-galactosidase protein fusions were used to identify the domain of yeast histone 2B, which targets this protein to the nucleus. Amino acids 28 to 33 in H2B were required for nuclear localization of such fusion proteins and thus constitute a nuclear localization sequence. The amino acid sequence in this region (Gly-29 Lys Lys Arg Ser Lys Ala)
Robert B. Moreland +4 more
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Structural Basis for the Specificity of Bipartite Nuclear Localization Sequence Binding by Importin-α [PDF]
Journal of Biological Chemistry, 2003 Importin-α is the nuclear import receptor that recognizes cargo proteins carrying conventional basic monopartite and bipartite nuclear localization sequences (NLSs) and facilitates their transport into the nucleus.
Marcos R.M. Fontes +4 more
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Role of the Nuclear Localization Sequence in Fibroblast Growth Factor-1-stimulated Mitogenic Pathways [PDF]
Journal of Biological Chemistry, 1996 Fibroblast growth factor-1 (FGF-1) is a potent mitogen for mesoderm- and neuroectoderm-derived cell types in vitro. However, a mutant FGF-1 with deletion in its nuclear localization sequence (NLS, residues 21-27) is not mitogenic in vitro.
Yao-Zhong Lin +2 more
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Phosphatidylinositol 3-Kinase C2α Contains a Nuclear Localization Sequence and Associates with Nuclear Speckles [PDF]
Journal of Biological Chemistry, 2001 Phosphoinositide 3-kinase C2alpha (PI3K-C2alpha) belongs to the class II phosphatidylinositol 3-kinases, which are defined by their in vitro usage of phosphatidylinositol and phosphatidylinositol 4-phosphate as substrates. All type II phosphatidylinositol 3-kinases contain at their C terminus a C2-like domain.
Svetlana A. Didichenko, Marcus Thelen
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