A nuclear targeting system in
Malaria Journal, 2010 Background The distinct differences in gene control mechanisms acting in the nucleus between Plasmodium falciparum and the human host could lead to new potential drug targets for anti-malarial development.
Kochakarn Theerarat +6 more
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Deletion of the nuclear localization sequence and C-terminus of parathyroid hormone–related protein decreases osteogenesis and chondrogenesis but increases adipogenesis and myogenesis in murine bone marrow stromal cells [PDF]
Journal of Tissue Engineering, 2015 The N-terminus of parathyroid hormone–related protein regulates bone marrow stromal cell differentiation. We hypothesized that the nuclear localization sequence and C-terminus are involved.
Blake E Hildreth +7 more
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Role of the Nuclear Localization Sequence in Fibroblast Growth Factor-1-stimulated Mitogenic Pathways [PDF]
Journal of Biological Chemistry, 1996 Fibroblast growth factor-1 (FGF-1) is a potent mitogen for mesoderm- and neuroectoderm-derived cell types in vitro. However, a mutant FGF-1 with deletion in its nuclear localization sequence (NLS, residues 21-27) is not mitogenic in vitro.
Yao-Zhong Lin +2 more
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Structural Basis for the Specificity of Bipartite Nuclear Localization Sequence Binding by Importin-α [PDF]
Journal of Biological Chemistry, 2003 Importin-α is the nuclear import receptor that recognizes cargo proteins carrying conventional basic monopartite and bipartite nuclear localization sequences (NLSs) and facilitates their transport into the nucleus.
Marcos R.M. Fontes +4 more
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Intracellular delivery of nuclear localization sequence peptide mitigates COVID-19 by inhibiting nuclear transport of inflammation-associated transcription factors. [PDF]
Mol Ther, 2023 Lee S +8 more
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The Effect of the Anticipated Nuclear Localization Sequence of 'Candidatus Phytoplasma mali' SAP11-like Protein on Localization of the Protein and Destabilization of TCP Transcription Factor. [PDF]
Microorganisms, 2021 Strohmayer A +4 more
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Characterization of a Novel Tripartite Nuclear Localization Sequence in the EGFR Family* [PDF]
Journal of Biological Chemistry, 2007 Aberrant expression of epidermal growth factor receptor (EGFR) is present in many human tumors. Several reports have shown that EGFR is translocated into the nucleus during liver regeneration and in several types of cells and tissues such as placenta and
S. Hsu, M. Hung
semanticscholar +3 more sources
The Nuclear Localization Signal of Lymphoid Enhancer Factor-1 Is Recognized by Two Differentially Expressed Srp1-Nuclear Localization Sequence Receptor Proteins [PDF]
Journal of Biological Chemistry, 1996 Proteins are directed to the nucleus by their nuclear localization sequences (NLSs) in a multistep process. The first step, which is to dock the NLS-containing protein to the nuclear pore, is carried out in part by a recently identified NLS receptor ...
Mary Prieve +3 more
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Molecular Pharmaceutics, 2015 Many recently discovered therapeutic proteins exert their main function in the nucleus, thus requiring both efficient uptake and correct intracellular targeting.
Salma N. Tammam +3 more
semanticscholar +3 more sources
Deciphering the Binding of the Nuclear Localization Sequence of Myc Protein to the Nuclear Carrier Importin α3. [PDF]
Int J Mol Sci, 2022 The oncoprotein Myc is a transcription factor regulating global gene expression and modulating cell proliferation, apoptosis, and metabolism. Myc has a nuclear localization sequence (NLS) comprising residues Pro320 to Asp328, to allow for nuclear translocation.
Rizzuti B, Iovanna JL, Neira JL.
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