Characterization of a Novel Tripartite Nuclear Localization Sequence in the EGFR Family* [PDF]
Journal of Biological Chemistry, 2007 Aberrant expression of epidermal growth factor receptor (EGFR) is present in many human tumors. Several reports have shown that EGFR is translocated into the nucleus during liver regeneration and in several types of cells and tissues such as placenta and
S. Hsu, M. Hung
semanticscholar +3 more sources
A monopartite nuclear localization sequence regulates nuclear targeting of the actin binding protein myopodin [PDF]
FEBS Letters, 2005 Myopodin is an actin bundling protein that shuttles between nucleus and cytoplasm in response to cell stress or during differentiation. Here, we show that the myopodin sequence 58KKRRRRARK66, when tagged to either enhanced green fluorescent protein (EGFP) or to enhanced cyan fluorescent protein‐CapG (ECFPCapG), is able to target these proteins to the ...
Ariane De Ganck +6 more
openalex +4 more sources
Intracellular delivery of nuclear localization sequence peptide mitigates COVID-19 by inhibiting nuclear transport of inflammation-associated transcription factors. [PDF]
Mol Ther, 2023 Lee S +8 more
europepmc +2 more sources
Molecular Pharmaceutics, 2015 Many recently discovered therapeutic proteins exert their main function in the nucleus, thus requiring both efficient uptake and correct intracellular targeting.
Salma N. Tammam +3 more
semanticscholar +3 more sources
The Effect of the Anticipated Nuclear Localization Sequence of 'Candidatus Phytoplasma mali' SAP11-like Protein on Localization of the Protein and Destabilization of TCP Transcription Factor. [PDF]
Microorganisms, 2021 Strohmayer A +4 more
europepmc +3 more sources
The Nuclear Localization Signal of Lymphoid Enhancer Factor-1 Is Recognized by Two Differentially Expressed Srp1-Nuclear Localization Sequence Receptor Proteins [PDF]
Journal of Biological Chemistry, 1996 Proteins are directed to the nucleus by their nuclear localization sequences (NLSs) in a multistep process. The first step, which is to dock the NLS-containing protein to the nuclear pore, is carried out in part by a recently identified NLS receptor ...
Mary Prieve +3 more
openalex +2 more sources
Efficiency of Importin α/β-Mediated Nuclear Localization Sequence Recognition and Nuclear Import [PDF]
Journal of Biological Chemistry, 1999 Little quantitative, kinetic information is available with respect to the process of nuclear import of conventional nuclear localization sequence (NLS)-containing proteins, which initially involves recognition and docking at the nuclear pore by importin ...
Wei Hu, David A. Jans
openalex +2 more sources
Golgin45 assists mitosis via its nuclear localization sequence.
Biochemical and Biophysical Research CommunicationsIn mammalian cells, the Golgi apparatus undergoes fragmentation for its correct partition into two daughter cells during mitosis. Several Golgi structural proteins have been demonstrated to regulate Golgi disassembly/reassembly and spindle formation. However, it is largely unknown whether Golgi proteins mediate other major events in mitosis.
Jingkai Gao +6 more
semanticscholar +3 more sources
The Nuclear Import of RCC1 Requires a Specific Nuclear Localization Sequence Receptor, Karyopherin α3/Qip [PDF]
Journal of Biological Chemistry, 2000 RCC1 is the only known guanine nucleotide exchange factor for the small GTPase Ran and is normally found inside the nucleus bound to chromatin. In order to analyze in more detail the nuclear import of RCC1, we created a fusion construct in which four IgG
Bradford Talcott, Mary Shannon Moore
openalex +2 more sources
A functional nuclear localization sequence in the VP1 capsid protein of coxsackievirus B3. [PDF]
Virology, 2012 The capsid proteins of some RNA viruses can translocate to the nucleus and interfere with cellular phenotypes. In this study we found that the VP1 capsid protein of coxsackievirus B3 (CVB3) was dominantly localized in the nucleus of the cells transfected with VP1-expressing plasmid.
Wang T +14 more
europepmc +4 more sources