The role of IFNγ nuclear localization sequence in intracellular function [PDF]
Journal of Cell Science, 2003 Intracellularly expressed interferon γ (IFNγ) has been reported to possess biological activity similar to that of IFNγ added to cells. This study addresses the mechanisms for such similar biological effects. Adenoviral vectors were used to express a non-secreted form of human IFNγ or a non-secreted mutant form in which a previously demonstrated nuclear
C. M. Iqbal Ahmed +4 more
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Cellular Import Mediated by Nuclear Localization Signal Peptide Sequences [PDF]
Chemistry & Biology, 2002 The cellular delivery of therapeutic agents and their localization within cells is currently a great challenge in medicinal chemistry. A few cationic peptides have shown a strong propensity to cross the cytoplasmic membrane and enter cells. Nuclear localization signal (NLS) sequences are a class of highly cationic peptides that may be exploited for ...
Angela D. Ragin +2 more
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Efficiency of Importin α/β-Mediated Nuclear Localization Sequence Recognition and Nuclear Import [PDF]
Journal of Biological Chemistry, 1999 Little quantitative, kinetic information is available with respect to the process of nuclear import of conventional nuclear localization sequence (NLS)-containing proteins, which initially involves recognition and docking at the nuclear pore by importin ...
Wei Hu, David A. Jans
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Multiple nuclear localization sequences in SRSF4 protein [PDF]
Genes to Cells, 2020 AbstractSRSF4 is one of the members of serine‐/arginine (SR)‐rich protein family involved in both constitutive and alternative splicing. SRSF4 is localized in the nucleus with speckled pattern, but its nuclear localization signal was not determined. Here, we have identified nuclear localization signals (NLSs) of SRSF4 by using a pyruvate kinase fusion ...
So Masaki +3 more
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Mitogen-Activated Protein Kinases Activate the Nuclear Localization Sequence of Human Papillomavirus Type 11 E1 DNA Helicase To Promote Efficient Nuclear Import [PDF]
Journal of Virology, 2007 Jei-Hwa Yu +4 more
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Rules for Nuclear Localization Sequence Recognition by Karyopherinβ2 [PDF]
Cell, 2006 Karyopherinbeta (Kapbeta) proteins bind nuclear localization and export signals (NLSs and NESs) to mediate nucleocytoplasmic trafficking, a process regulated by Ran GTPase through its nucleotide cycle. Diversity and complexity of signals recognized by Kap betas have prevented prediction of new Kap beta substrates.
Brittany J. Lee +5 more
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Deletion of PTHrP nuclear localization sequence and carboxyl terminus leads to lung dysplasia. [PDF]
Sci RepLi Y +5 more
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Identification of Nuclear Localization Sequence (NLS) Sites in R2R3-MYB Transcription Factor Involved in Anther Development. [PDF]
CellsZhou SD +7 more
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The Aspergillus nidulans velvet domain containing transcription factor VeA is shuttled from cytoplasm into nucleus during vegetative growth and stays there for sexual development, but has to return into cytoplasm for asexual development. [PDF]
PLoS GeneticsSurvival of multicellular organisms requires the coordinated interplay between networks regulating gene expression and controlled intracellular transport of respective regulators.
Anja Strohdiek +9 more
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Amino acid sequences that determine the nuclear localization of yeast histone 2B. [PDF]
Molecular and Cellular Biology, 1987 Histone-beta-galactosidase protein fusions were used to identify the domain of yeast histone 2B, which targets this protein to the nucleus. Amino acids 28 to 33 in H2B were required for nuclear localization of such fusion proteins and thus constitute a nuclear localization sequence. The amino acid sequence in this region (Gly-29 Lys Lys Arg Ser Lys Ala)
Robert B. Moreland +4 more
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