Results 31 to 40 of about 929,541 (348)

Distinct structural features of G protein-coupled receptor kinase 5 (GRK5) regulate its nuclear localization and DNA-binding ability. [PDF]

open access: yesPLoS ONE, 2013
G protein-coupled receptor kinases (GRKs) act to desensitize G protein-coupled receptors (GPCRs). In addition to this role at the plasma membrane, a nuclear function for GRK5, a member of the GRK4 subfamily of GRKs, has been reported. GRK5 phosphorylates
Laura R Johnson   +3 more
doaj   +1 more source

Calcium-Activated Big-Conductance (BK) Potassium Channels Traffic through Nuclear Envelopes into Kinocilia in Ray Electrosensory Cells

open access: yesCells, 2023
Electroreception through ampullae of Lorenzini in the little skate, Leucoraja erinacea, involves functional coupling between voltage-activated calcium channels (CaV1.3, cacna1d) and calcium-activated big-conductance potassium (BK) channels (BK, kcnma1 ...
Abby L. Chen   +4 more
doaj   +1 more source

A Balance Between Two Nuclear Localization Sequences and a Nuclear Export Sequence Governs Extradenticle Subcellular Localization [PDF]

open access: yesGenetics, 2007
Abstract During animal development, transcription factor activities are modulated by several means, including subcellular localization. The Hox cofactor Extradenticle (Exd) has a dynamic subcellular localization, such that Exd is cytoplasmic by default, but is nuclear when complexed with another homeodomain protein, Homothorax (Hth ...
Katherine E. Stevens, Richard S. Mann
openaire   +2 more sources

Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2. [PDF]

open access: yesPLoS ONE, 2011
Interferon regulatory factor 2 binding protein 2 (IRF2BP2) is a muscle-enriched transcription factor required to activate vascular endothelial growth factor-A (VEGFA) expression in muscle.
Allen C T Teng   +6 more
doaj   +1 more source

Yeast proteins that recognize nuclear localization sequences. [PDF]

open access: yesThe Journal of cell biology, 1989
A variety of peptides can mediate the localization of proteins to the nucleus. We have identified yeast proteins of 70 and 59 kD that bind to nuclear localization peptides of SV-40 T antigen, Xenopus nucleoplasmin, and the yeast proteins Ga14 and histone H2B.
Pamela A. Silver   +2 more
openaire   +2 more sources

Characterization of sequences in human TWIST required for nuclear localization [PDF]

open access: yesBMC Cell Biology, 2009
Twist is a transcription factor that plays an important role in proliferation and tumorigenesis. Twist is a nuclear protein that regulates a variety of cellular functions controlled by protein-protein interactions and gene transcription events. The focus of this study was to characterize putative nuclear localization signals (NLSs) 37RKRR40 and ...
Singh, Shalini, Gramolini, Anthony O
openaire   +5 more sources

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