Phosphatidylinositol 3-Kinase C2α Contains a Nuclear Localization Sequence and Associates with Nuclear Speckles [PDF]
Journal of Biological Chemistry, 2001 Phosphoinositide 3-kinase C2alpha (PI3K-C2alpha) belongs to the class II phosphatidylinositol 3-kinases, which are defined by their in vitro usage of phosphatidylinositol and phosphatidylinositol 4-phosphate as substrates. All type II phosphatidylinositol 3-kinases contain at their C terminus a C2-like domain.
Svetlana A. Didichenko, Marcus Thelen
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Correction for Miao et al., Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein. [PDF]
Proc Natl Acad Sci U S Aeuropepmc +3 more sources
Distinct structural features of G protein-coupled receptor kinase 5 (GRK5) regulate its nuclear localization and DNA-binding ability. [PDF]
PLoS ONE, 2013 G protein-coupled receptor kinases (GRKs) act to desensitize G protein-coupled receptors (GPCRs). In addition to this role at the plasma membrane, a nuclear function for GRK5, a member of the GRK4 subfamily of GRKs, has been reported. GRK5 phosphorylates
Laura R Johnson +3 more
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Cells, 2023 Electroreception through ampullae of Lorenzini in the little skate, Leucoraja erinacea, involves functional coupling between voltage-activated calcium channels (CaV1.3, cacna1d) and calcium-activated big-conductance potassium (BK) channels (BK, kcnma1 ...
Abby L. Chen +4 more
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A Balance Between Two Nuclear Localization Sequences and a Nuclear Export Sequence Governs Extradenticle Subcellular Localization [PDF]
Genetics, 2007 Abstract During animal development, transcription factor activities are modulated by several means, including subcellular localization. The Hox cofactor Extradenticle (Exd) has a dynamic subcellular localization, such that Exd is cytoplasmic by default, but is nuclear when complexed with another homeodomain protein, Homothorax (Hth ...
Katherine E. Stevens, Richard S. Mann
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Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2. [PDF]
PLoS ONE, 2011 Interferon regulatory factor 2 binding protein 2 (IRF2BP2) is a muscle-enriched transcription factor required to activate vascular endothelial growth factor-A (VEGFA) expression in muscle.
Allen C T Teng +6 more
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Yeast proteins that recognize nuclear localization sequences. [PDF]
The Journal of cell biology, 1989 A variety of peptides can mediate the localization of proteins to the nucleus. We have identified yeast proteins of 70 and 59 kD that bind to nuclear localization peptides of SV-40 T antigen, Xenopus nucleoplasmin, and the yeast proteins Ga14 and histone H2B.
Pamela A. Silver +2 more
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Characterization of sequences in human TWIST required for nuclear localization [PDF]
BMC Cell Biology, 2009 Twist is a transcription factor that plays an important role in proliferation and tumorigenesis. Twist is a nuclear protein that regulates a variety of cellular functions controlled by protein-protein interactions and gene transcription events. The focus of this study was to characterize putative nuclear localization signals (NLSs) 37RKRR40 and ...
Singh, Shalini, Gramolini, Anthony O
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Specific Binding of Nuclear Localization Sequences to Plant Nuclei [PDF]
The Plant Cell, 1993 We have begun to dissect the import apparatus of higher plants by examining the specific association of nuclear localization sequences (NLSs) with purified plant nuclei. Peptides to the simian virus 40 (SV40) large T antigen NLS and a bipartite NLS of maize were allowed to associate with tobacco and maize nuclei.
Glenn R. Hicks, Natasha V. Raikhel
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Identification of the sequence responsible for the nuclear localization of human Cdc6 [PDF]
FEBS Letters, 1999 The Cdc6 is the essential protein for the initiation of DNA replication. Cdc6 is localized in the G1 nucleus, and abnormal nuclear localization of this protein induces irregular initiation of DNA replication. We identified here that amino acids K57 and R58 in the human Cdc6 protein play an important role in the nuclear localization of the protein.
Koshi Yamamoto +2 more
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