Role of pore dilation in molecular transport through the nuclear pore complex: Insights from polymer scaling theory. [PDF]
PLoS Comput Biol, 2023 Recent studies have suggested that the Nuclear Pore Complex (NPC) plays a significant role in mechanotransduction. When a force is exerted, the NPC's diameter widens, leading to an increased molecular flux into the nucleus. In this study, we sought to further explore this phenomenon and quantitativelly assess the impact of pore dilation on molecular ...
Matsuda A, Mofrad MRK.
europepmc +2 more sources
Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions [PDF]
mBioViruses and bacteria exploit the nuclear pore complex (NPC) and host nuclear functions to bypass cellular barriers and manipulate essential processes. Viruses frequently engage directly with NPC components, such as nucleoporins, to enable genome import ...
Brianna Steiert, Mary M. Weber
doaj +2 more sources
Detailed characterisation of the trypanosome nuclear pore architecture reveals conserved asymmetrical functional hubs that drive mRNA export. [PDF]
PLoS BiologyNuclear export of mRNAs requires loading the mRNP to the transporter Mex67/Mtr2 in the nucleoplasm, controlled access to the pore by the basket-localised TREX-2 complex and mRNA release at the cytoplasmic site by the DEAD-box RNA helicase Dbp5 ...
Bernardo Papini Gabiatti +5 more
doaj +2 more sources
The nuclear envelope and nuclear pore complexes in neurodegenerative diseases [PDF]
Frontiers in Cell and Developmental BiologyThe nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Tingyan Wu +10 more
doaj +2 more sources
Nucleoporin downregulation modulates progenitor differentiation independent of nuclear pore numbers [PDF]
Communications Biology, 2023 Nucleoporins (NUPs) comprise nuclear pore complexes, gateways for nucleocytoplasmic transport. As primary human keratinocytes switch from the progenitor state towards differentiation, most NUPs are strongly downregulated, with NUP93 being the most ...
Amy E. Neely +7 more
doaj +2 more sources
Nuclear pore dysfunction and disease: a complex opportunity [PDF]
NucleusThe separation of genetic material from bulk cytoplasm has enabled the evolution of increasingly complex organisms, allowing for the development of sophisticated forms of life. However, this complexity has created new categories of dysfunction, including
Charlotte M. Fare, Jeffrey D. Rothstein
doaj +2 more sources
Diameter dependence of transport through nuclear pore complex mimics studied using optical nanopores [PDF]
eLifeThe nuclear pore complex (NPC) regulates the selective transport of large biomolecules through the nuclear envelope. As a model system for nuclear transport, we construct NPC mimics by functionalizing the pore walls of freestanding palladium zero-mode ...
Nils Klughammer +5 more
doaj +2 more sources
The nuclear pore complex [PDF]
The Journal of cell biology, 1993 Over the past years, significant progress has been made both in the analysis of the structural and molecular organization of the nuclear pore complex (NPC) and the mechanism of nuclear transport. In this minireview, I will focus on some of the recent developments in this field.
Ueli Aebi, Nelly Panté
openaire +7 more sources
Architecture of the cytoplasmic face of the nuclear pore
Science, 2022 Description INTRODUCTION The subcellular compartmentalization of eukaryotic cells requires selective transport of folded proteins and protein–nucleic acid complexes.
C. J. Bley +20 more
semanticscholar +1 more source
Architecture of the linker-scaffold in the nuclear pore
Science, 2022 Description INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC).
S. Petrovic +12 more
semanticscholar +1 more source