Results 11 to 20 of about 2,343,531 (340)

Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells. [PDF]

PLoS ONE, 2011
Tpr is a large coiled-coil protein located in the nuclear basket of the nuclear pore complex for which many different functions were proposed from yeast to human.Here we show that depletion of Tpr by RNA interference triggers G0-G1 arrest and ultimately ...
Brigitte David-Watine
doaj   +6 more sources

Nuclear Envelope: Nuclear Pore Complexity [PDF]

Current Biology, 2005
A new study shows that the filamentous fungus, Aspergillus nidulans, which has a closed mitosis, does not maintain a continuous permeability barrier during mitosis. This work challenges current views of the differences between closed and open mitosis and has implications for understanding mitotic specific changes in the nuclear pore complex and Ran ...
Sazer, Shelley
openaire   +5 more sources

Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes

eLife, 2020
The nucleus of oocytes (germinal vesicle) is unusually large and its nuclear envelope (NE) is densely packed with nuclear pore complexes (NPCs) that are stockpiled for embryonic development.
Natalia Wesolowska, Ivan Avilov, Pedro Machado, Celina Geiss, Hiroshi Kondo, Masashi Mori, Peter Lenart   +6 more
doaj   +2 more sources

Bistable collective behavior of polymers tethered in a nanopore [PDF]

Physical Review E. 85(2012) 061917, 2011
Polymer-coated pores play a crucial role in nucleo-cytoplasmic transport and in a number of biomimetic and nanotechnological applications. Here we present Monte Carlo and Density Functional Theory approaches to identify different collective phases of end-grafted polymers in a nanopore and to study their relative stability as a function of ...
Bailey, J, Fassati, A, Ford, IJ, Harker, AH, Hoogenboom, BW, Osmanovic, D   +5 more
arxiv   +5 more sources

Diffusion of Macromolecules across the Nuclear Pore Complex [PDF]

, 2007
Nuclear pore complexes (NPCs) are very selective filters that monitor the transport between the cytoplasm and the nucleoplasm. Two models have been suggested for the plug of the NPC. They are (i) it is a reversible hydrogel or (ii) it is a polymer brush.
Alber, Alber, Ananya Debnath, Banik, Ben-Efraim, Bhattacharjee, Bickel, Cardarelli, Cardarelli, Chakrabarti, Chakrabarti, Chatterjee, Das, Doi, Elbaum, Fahrenkrog, Feldherr, Fiserova, Frey, Frey, Grünwald, Görlich, Herrman, Isgro, Isgro, Isgro, Justin Yamada, K.L. Sebastian, Kawakatsu, Keminer, Kim, Koutsioubas, Kowalczyk, Kraikvski, Kraikvski, Kubitscheck, Kustanovich, Landau, Leitenberger, Lim, Lim, Liu, Lowe, Ma, Ma, Maarel, Marcerou, Milner, Moussavi-Baygi, Moussavi-Baygi, Nielsen, Paine, Patel, Peters, Rajaraman, Rajarshi Chakrabarti, Reister, Ribbeck, Rout, Rout, Sebastian, Sebastian, Sebastian, Sprakel, Sprakel, Tabatabaei, Tran, Weise, Xu, Yang, Zilman, Zinn-Justin   +71 more
arxiv   +3 more sources

Redox-Sensitive Cysteines Confer Proximal Control of the Molecular Crowding Barrier in the Nuclear Pore [PDF]

Cell Reports, 2020
Summary: The nuclear pore complex forms a highly crowded selective barrier with intrinsically disordered regions at the nuclear membrane to coordinate nucleocytoplasmic molecular communications.
Wanzhen Zhang, Ryuji Watanabe, Hide A. Konishi, Takahiro Fujiwara, Shige H. Yoshimura, Masahiro Kumeta   +5 more
doaj   +3 more sources

Nucleocytoplasmic transport: a thermodynamic mechanism [PDF]

arXiv, 2009
The nuclear pore supports molecular communication between cytoplasm and nucleus in eukaryotic cells. Selective transport of proteins is mediated by soluble receptors, whose regulation by the small GTPase Ran leads to cargo accumulation in, or depletion from the nucleus, i.e., nuclear import or nuclear export. We consider the operation of this transport
Adam SA, Akey CW, Alber F, Bapteste E, Beck M, Becskei A, Ben‐Efraim I, Bickel T, Caspi Y, Catimel B, Cingolani G, Coppey M, Costa M, Cronshaw JM, Dange T, Denning DP, Devos D, Dixon M, Fanara P, Fradin C, Fradin C, Frey S, Grünwald D, Görlich D, Haldane JBS, Harreman MT, Henderson GP, Hinshaw JE, Hodel AE, Hu W, Hübner S, Jovanovic‐Talisman T, Kalab P, Kalderon D, Kapon R, Kobe B, Kopito RB, Kose S, Kotera I, Kubitscheck U, Kustanovich T, Köhler M, Lam MH, Lee SJ, Lyman SK, Mans BJ, Melcák I, Michael Elbaum, Michael WM, Miyamoto Y, Nachury MV, Naim B, Nakielny S, Newmeyer DD, Ossareh‐Nazari B, Pederson T, Pollard VW, Pyhtila B, Ribbeck K, Ribbeck K, Riddick G, Riddick G, Rihs HP, Robbins J, Ronen Benjamine Kopito, Rout MP, Salman H, Schmidt‐Zachmann MS, Schwartz TU, Shah S, Smith A, Stade K, Steggerda SM, Stein WD, Stoffler D, Strawn LA, Timney BL, Tokunaga M, Wen W, Yang Q, Yang W, Yang W, Zeitler B, Zilman A   +83 more
arxiv   +4 more sources

The cellular environment shapes the nuclear pore complex architecture

Nature, 2021
Nuclear pore complexes (NPCs) create large conduits for cargo transport between the nucleus and cytoplasm across the nuclear envelope (NE)1–3. These multi-megadalton structures are composed of about thirty different nucleoporins that are distributed in ...
A. Schuller, M. Wojtynek, David Mankus, M. Tatli, R. Kronenberg-Tenga, S. Regmi, P. Dip, Abigail K. R. Lytton-Jean, E. Brignole, M. Dasso, K. Weis, O. Medalia, T. Schwartz   +12 more
semanticscholar   +1 more source

Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells. [PDF]

PLoS ONE, 2015
Annulate lamellae are cytoplasmic organelles containing stacked sheets of membranes embedded with pore complexes. These cytoplasmic pore complexes at annulate lamellae are morphologically similar to nuclear pore complexes at the nuclear envelope ...
Sarita Raghunayakula, Divya Subramonian, Mary Dasso, Rita Kumar, Xiang-Dong Zhang   +4 more
doaj   +1 more source

Comprehensive structure and functional adaptations of the yeast nuclear pore complex

Cell, 2021
Nuclear Pore Complexes (NPCs) mediate the nucleocytoplasmic transport of macromolecules. Here we provide a structure of the yeast NPC in which the inner ring is resolved by cryo-EM at - helical resolution to show how flexible connectors tie together ...
C. Akey, Digvijay Singh, Christna Ouch, Ignacia Echeverria, I. Nudelman, Joseph M. Varberg, Zulin Yu, Fei Fang, Yi Shi, Junjie Wang, Daniel Salzberg, Kangkang Song, Chen Xu, J. Gumbart, S. Suslov, J. Unruh, Sue L. Jaspersen, B. Chait, A. Sali, Javier Fernandez-Martinez, S. Ludtke, E. Villa, M. Rout   +22 more
semanticscholar   +1 more source