Results 11 to 20 of about 326,922 (335)

Redox-Sensitive Cysteines Confer Proximal Control of the Molecular Crowding Barrier in the Nuclear Pore [PDF]

Cell Reports, 2020
Summary: The nuclear pore complex forms a highly crowded selective barrier with intrinsically disordered regions at the nuclear membrane to coordinate nucleocytoplasmic molecular communications.
Wanzhen Zhang, Ryuji Watanabe, Hide A. Konishi, Takahiro Fujiwara, Shige H. Yoshimura, Masahiro Kumeta   +5 more
doaj   +2 more sources

The nuclear envelope and nuclear pore complexes in neurodegenerative diseases [PDF]

Frontiers in Cell and Developmental Biology
The nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Tingyan Wu, Tingyan Wu, Haochen Xu, Haochen Xu, Lei Cheng, Lei Cheng, Ruoxin Wu, Ruoxin Wu, Fuzheng Guo, Xi Chen, Xi Chen   +10 more
doaj   +2 more sources

Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions [PDF]

mBio
Viruses and bacteria exploit the nuclear pore complex (NPC) and host nuclear functions to bypass cellular barriers and manipulate essential processes. Viruses frequently engage directly with NPC components, such as nucleoporins, to enable genome import ...
Brianna Steiert, Mary M. Weber
doaj   +2 more sources

Diameter dependence of transport through nuclear pore complex mimics studied using optical nanopores

eLife, 2023
The nuclear pore complex (NPC) regulates the selective transport of large biomolecules through the nuclear envelope. As a model system for nuclear transport, we construct NPC mimics by functionalizing the pore walls of freestanding palladium zero-mode ...
Nils Klughammer, Anders Barth, Maurice Dekker, Alessio Fragasso, Patrick R Onck, Cees Dekker   +5 more
doaj   +2 more sources

Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

Nature Communications, 2021
The involvement of nuclear pore proteins in cellular mechanosensing and metastasis is unclear. Here the authors identify that nuclear pore protein NUP210 promotes metastasis through the interaction with mechanotransducer LINC complex protein and ...
Ruhul Amin, Anjali Shukla, Jacqueline Jufen Zhu, Sohyoung Kim, Ping Wang, Simon Zhongyuan Tian, Andy D. Tran, Debasish Paul, Steven D. Cappell, Sandra Burkett, Huaitian Liu, Maxwell P. Lee, Michael J. Kruhlak, Jennifer E. Dwyer, R. Mark Simpson, Gordon L. Hager, Yijun Ruan, Kent W. Hunter   +17 more
doaj   +2 more sources

Detailed characterisation of the trypanosome nuclear pore architecture reveals conserved asymmetrical functional hubs that drive mRNA export. [PDF]

PLoS Biology
Nuclear export of mRNAs requires loading the mRNP to the transporter Mex67/Mtr2 in the nucleoplasm, controlled access to the pore by the basket-localised TREX-2 complex and mRNA release at the cytoplasmic site by the DEAD-box RNA helicase Dbp5 ...
Bernardo Papini Gabiatti, Johanna Krenzer, Silke Braune, Timothy Krüger, Martin Zoltner, Susanne Kramer   +5 more
doaj   +2 more sources

Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s disease [PDF]

eLife
The emergence of Aβ pathology is one of the hallmarks of Alzheimer’s disease (AD), but the mechanisms and impact of Aβ in progression of the disease is unclear.
Vibhavari Aysha Bansal, Jia Min Tan, Hui Rong Soon, Norliyana Zainolabidin, Takaomi Saido, Toh Hean Ch'ng   +5 more
doaj   +2 more sources

Channel width modulates the permeability of DNA origami-based nuclear pore mimics. [PDF]

Sci Adv
Feng Q, Saladin M, Wu C, Cao E, Zheng W, Zhang A, Bhardwaj P, Li X, Shen Q, Kapinos LE, Kozai T, Mariappan M, Lusk CP, Xiong Y, Lim RYH, Lin C.   +15 more
europepmc   +3 more sources

Protocol to image and quantify nuclear pore complexes using high-resolution laser scanning confocal microscopy

STAR Protocols, 2023
Summary: Nuclear pore complexes are pathways for nuclear-cytoplasmic communication that participate in chromatin organization. Here, we present a protocol to image and quantify the number of nuclear pore complexes in cells.
Jocelyn D. Mich-Basso, Bernhard Kühn
doaj   +1 more source

Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells. [PDF]

PLoS ONE, 2015
Annulate lamellae are cytoplasmic organelles containing stacked sheets of membranes embedded with pore complexes. These cytoplasmic pore complexes at annulate lamellae are morphologically similar to nuclear pore complexes at the nuclear envelope ...
Sarita Raghunayakula, Divya Subramonian, Mary Dasso, Rita Kumar, Xiang-Dong Zhang   +4 more
doaj   +1 more source