Results 11 to 20 of about 2,248,811 (276)

Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions [PDF]

mBio
Viruses and bacteria exploit the nuclear pore complex (NPC) and host nuclear functions to bypass cellular barriers and manipulate essential processes. Viruses frequently engage directly with NPC components, such as nucleoporins, to enable genome import ...
Brianna Steiert, Mary M. Weber
doaj   +2 more sources

Detailed characterisation of the trypanosome nuclear pore architecture reveals conserved asymmetrical functional hubs that drive mRNA export. [PDF]

PLoS Biology
Nuclear export of mRNAs requires loading the mRNP to the transporter Mex67/Mtr2 in the nucleoplasm, controlled access to the pore by the basket-localised TREX-2 complex and mRNA release at the cytoplasmic site by the DEAD-box RNA helicase Dbp5 ...
Bernardo Papini Gabiatti, Johanna Krenzer, Silke Braune, Timothy Krüger, Martin Zoltner, Susanne Kramer   +5 more
doaj   +2 more sources

The nuclear envelope and nuclear pore complexes in neurodegenerative diseases [PDF]

Frontiers in Cell and Developmental Biology
The nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Tingyan Wu, Tingyan Wu, Haochen Xu, Haochen Xu, Lei Cheng, Lei Cheng, Ruoxin Wu, Ruoxin Wu, Fuzheng Guo, Xi Chen, Xi Chen   +10 more
doaj   +2 more sources

Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s disease [PDF]

eLife
The emergence of Aβ pathology is one of the hallmarks of Alzheimer’s disease (AD), but the mechanisms and impact of Aβ in progression of the disease is unclear.
Vibhavari Aysha Bansal, Jia Min Tan, Hui Rong Soon, Norliyana Zainolabidin, Takaomi Saido, Toh Hean Ch'ng   +5 more
doaj   +2 more sources

The nuclear pore complex [PDF]

The Journal of cell biology, 1996
Nelly Panté, Ueli Aebi
openalex   +4 more sources

Diameter dependence of transport through nuclear pore complex mimics studied using optical nanopores [PDF]

eLife
The nuclear pore complex (NPC) regulates the selective transport of large biomolecules through the nuclear envelope. As a model system for nuclear transport, we construct NPC mimics by functionalizing the pore walls of freestanding palladium zero-mode ...
Nils Klughammer, Anders Barth, Maurice Dekker, Alessio Fragasso, Patrick R Onck, Cees Dekker   +5 more
doaj   +2 more sources

Architecture of the cytoplasmic face of the nuclear pore

Science, 2022
Description INTRODUCTION The subcellular compartmentalization of eukaryotic cells requires selective transport of folded proteins and protein–nucleic acid complexes.
C. J. Bley, Si-Huai Nie, G. Mobbs, S. Petrovic, A. Gres, Xiaoyu Liu, S. Mukherjee, S. Harvey, F. Huber, D. H. Lin, Bonnie Brown, Aaron W. Tang, E. J. Rundlet, A. R. Correia, Shane Chen, S. Regmi, M. Dasso, Alina Patke, Alexander F. Palazzo, A. Kossiakoff, A. Hoelz   +20 more
semanticscholar   +1 more source

Architecture of the linker-scaffold in the nuclear pore

Science, 2022
Description INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC).
S. Petrovic, Dipanjan Samanta, T. Perriches, C. J. Bley, K. Thierbach, Bonnie Brown, Siqing Nie, G. Mobbs, T. Stevens, Xiaoyu Liu, G. P. Tomaleri, Lucas Schaus, A. Hoelz   +12 more
semanticscholar   +1 more source

The cellular environment shapes the nuclear pore complex architecture

Nature, 2021
Nuclear pore complexes (NPCs) create large conduits for cargo transport between the nucleus and cytoplasm across the nuclear envelope (NE)1–3. These multi-megadalton structures are composed of about thirty different nucleoporins that are distributed in ...
A. Schuller, M. Wojtynek, David Mankus, M. Tatli, R. Kronenberg-Tenga, S. Regmi, P. Dip, Abigail K. R. Lytton-Jean, E. Brignole, M. Dasso, K. Weis, O. Medalia, T. Schwartz   +12 more
semanticscholar   +1 more source

Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells. [PDF]

PLoS ONE, 2015
Annulate lamellae are cytoplasmic organelles containing stacked sheets of membranes embedded with pore complexes. These cytoplasmic pore complexes at annulate lamellae are morphologically similar to nuclear pore complexes at the nuclear envelope ...
Sarita Raghunayakula, Divya Subramonian, Mary Dasso, Rita Kumar, Xiang-Dong Zhang   +4 more
doaj   +1 more source