Results 241 to 250 of about 1,947,312 (301)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Visualizing nuclear pore complex plasticity with pan-expansion microscopy. [PDF]

J Cell Biol
Morgan KJ, Carley E, Coyne AN, Rothstein JD, Lusk CP, King MC.   +5 more
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Breaking barriers: Respiratory viral strategies targeting the host's nuclear pore complex and nuclear transport pathways. [PDF]

Mol Biol Cell
Udi Y, Aitchison JD, Rout MP, Obado S.
europepmc   +1 more source

Transcriptional condensates and the nuclear pore complex regulate gene expression and 3D genome architecture in response to stress. [PDF]

Biochem Soc Trans
Mohajan S, Gross DS.
europepmc   +1 more source

Direct visualization of HIV-1 core nuclear import and its interplay with the nuclear pore. [PDF]

EMBO Rep
Hou Z, Fronik S, Shen Y, Chen L, Thompson C, Neumann S, Zhang P.   +6 more
europepmc   +1 more source

Homeostatic regulation of nucleoporins is a central driver of nuclear pore biogenesis. [PDF]

Cell Rep
Sakuma S, Raices M, Zhu EYS, Mamriev D, Fisher CI, Heynen-Genel S, D'Angelo MA.   +6 more
europepmc   +1 more source

C9ORF72-derived polyGR polypeptides disrupt passive nucleocytoplasmic transport by tuning protein affinity for the nuclear pore barrier

Solomon DA, Emenecker RJ, Salcher-Konrad M, Konstantinidou SM, Houghton OH, Wycherley E, Lee S, O’Brien NL, Alcalde J, Cabaço IL, Ruepp M, Schmidt HB, Holehouse AS, Mizielinska S.   +13 more
europepmc   +1 more source

Nuclear pore passage of the HIV capsid is driven by its unusual surface amino acid composition. [PDF]

Nat Struct Mol Biol
Fu L, Cheng S, Riedel D, Kopecny L, Schuh M, Görlich D.   +5 more
europepmc   +1 more source

Detecting Nuclear Pore Complex assembly in living cells

Veldsink AC, Fischer JS, Terpstra HM, Mannino PJ, de Lange EM, Hell S, van Benthem KJ, Saba LJ, Steen A, Vlijm R, Heinemann M, Weis K, Lusk CP, Veenhoff LM.   +13 more
europepmc   +1 more source