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Annual Review of Biochemistry, 1995
The nuclear pore complex (NPC) creates an aqueous channel across the nuclear envelope through which macromolecular transport between nucleus and cytoplasm occurs. Nucleocytoplasmic traffic is bidirectional and involves diverse substrates, including protein and RNA.
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The nuclear pore complex (NPC) creates an aqueous channel across the nuclear envelope through which macromolecular transport between nucleus and cytoplasm occurs. Nucleocytoplasmic traffic is bidirectional and involves diverse substrates, including protein and RNA.
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Pores for thought: nuclear pore complex proteins
Trends in Cell Biology, 1994Nuclear pore complexes (NPCs) are enormous macromolecular structures that mediate the active exchange of proteins and RNPs between the nucleus and cytoplasm. Recent work has resulted in a windfall of identified NPC polypeptides, many with unique sequences.
M P, Rout, S R, Wente
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Solving the nuclear pore puzzle
Science, 2022Using a battery of tools, the architecture of the nuclear pore complex is ...
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Autoantigens of the nuclear pore complex
Journal of Molecular Medicine, 2004The nuclear envelope (NE) is one of many intracellular targets of the autoimmune response in patients with autoimmune liver disease, systemic lupus erythematosus, and related conditions. In eukaryotic organisms the NE consists of five interconnected regions: an outer nuclear membrane (ONM) that is continuous with the endoplasmic reticulum, an ...
P, Enarson +5 more
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The nuclear pore comes to the fore
Trends in Plant Science, 2008The nuclear pore complex is the gateway of macromolecular trafficking between the nucleus and the cytoplasm. Although its composition is well characterized in yeast and mammalian systems, little is known about the plant nuclear pore. Several recent reports describe complex whole-organism phenotypes based on mutations in plant nucleoporins. The pathways
Xianfeng M, Xu, Iris, Meier
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1996
The nuclear envelope forms the boundary between the nucleus and the cytoplasm and as such regulates the exchange of macromolecules between the two compartments. The channels through the nuclear envelop that actually mediate this macromolecular traffic are the nuclear pore complexes.
R, Bastos, N, Panté, B, Burke
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The nuclear envelope forms the boundary between the nucleus and the cytoplasm and as such regulates the exchange of macromolecules between the two compartments. The channels through the nuclear envelop that actually mediate this macromolecular traffic are the nuclear pore complexes.
R, Bastos, N, Panté, B, Burke
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Nuclear pore structure and function
Seminars in Cell Biology, 1992Nuclear pores are huge macromolecular assemblies, approximately 120 nm in diameter, that perforate the nuclear membrane and mediate nucleocytoplasmic transport. Nuclear pores are constructed from a cylindrical spoke-plug complex sandwiched between nucleoplasmic and cytoplasmic rings.
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The Structure of the Nuclear Pore Complex
Annual Review of Biochemistry, 2011In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and translation in the cytoplasm imposes the requirement of transporting thousands of macromolecules between these two compartments. Nuclear pore complexes (NPCs) are the sole gateways that facilitate this macromolecular exchange across the nuclear envelope ...
Hoelz, André +2 more
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Pores in the mammalian nuclear membrane
Biochimica et Biophysica Acta, 1954Resume La microscopie electronique de sections minces de la membrane nucleaire du pancreas de souris demontre l'existence d'une structure en pores. Les parties internes et externes de la membrane nucleaire se rejoignent a la peripherie des pores qui traversent ainis completement la membrane.
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