Results 21 to 30 of about 326,922 (335)
Acta Neuropathologica Communications, 2021 Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon characterized by the reduction of specific ...
Alyssa N. Coyne, Jeffrey D. Rothstein
doaj +1 more source
Current Biology, 2003 What are they? Nuclear pore complexes (NPCs) are often referred to as the ‘gatekeepers of the nucleus’, being responsible for regulating the molecular traffic – from ions to ribosomes – between the nucleoplasm and the cytoplasm. A typical vertebrate nucleus has about 5,000 NPCs scattered over its surface.What do they look like? A picture is worth twice
Wozniak, Richard W, Lusk, C.Patrick
openaire +2 more sources
Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes. [PDF]
, 2020 The nucleus of oocytes (germinal vesicle) is unusually large and its nuclear envelope (NE) is densely packed with nuclear pore complexes (NPCs) stockpiled for embryonic development. We showed that breakdown of this specialized NE is mediated by an Arp2/3-
Avilov, I. +6 more
core +1 more source
A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis
Open Biology, 2021 The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex (NPC) biogenesis factors Brl1 and Brr6. How Apq12 executes these functions is unknown.
Wanlu Zhang +8 more
doaj +1 more source
The nuclear pore complex [PDF]
The Journal of cell biology, 1993 Over the past years, significant progress has been made both in the analysis of the structural and molecular organization of the nuclear pore complex (NPC) and the mechanism of nuclear transport. In this minireview, I will focus on some of the recent developments in this field.
N, Panté, U, Aebi
openaire +5 more sources
Generating Membrane Curvature at the Nuclear Pore: A Lipid Point of View
Cells, 2022 In addition to its structural role in enclosing and protecting the genome, the nuclear envelope (NE) forms a highly adaptive communication interface between the cytoplasm and the nuclear interior in eukaryotic cells.
Bas W. A. Peeters +2 more
doaj +1 more source
Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells. [PDF]
PLoS ONE, 2011 Tpr is a large coiled-coil protein located in the nuclear basket of the nuclear pore complex for which many different functions were proposed from yeast to human.Here we show that depletion of Tpr by RNA interference triggers G0-G1 arrest and ultimately ...
Brigitte David-Watine
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 Apicomplexa are obligate intracellular parasites which cause various animal and human diseases including malaria, toxoplasmosis, and cryptosporidiosis. They proliferate by a unique mechanism that combines physically separated semi-closed mitosis of the ...
Maria E. Francia +7 more
doaj +1 more source
Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly [PDF]
, 2011 During mitosis, the nuclear envelope merges with the endoplasmic reticulum (ER), and nuclear pore complexes are disassembled. In a current model for reassembly after mitosis, the nuclear envelope forms by a reshaping of ER tubules.
Anderson +48 more
core +4 more sources
Nucleoporin downregulation modulates progenitor differentiation independent of nuclear pore numbers
Communications Biology, 2023 Nucleoporins (NUPs) comprise nuclear pore complexes, gateways for nucleocytoplasmic transport. As primary human keratinocytes switch from the progenitor state towards differentiation, most NUPs are strongly downregulated, with NUP93 being the most ...
Amy E. Neely +7 more
doaj +1 more source