Results 21 to 30 of about 2,248,811 (276)

In-cell architecture of the nuclear pore and snapshots of its turnover

Nature, 2020
Nuclear pore complexes (NPCs) fuse the inner and outer membranes of the nuclear envelope. They comprise hundreds of nucleoporins (Nups) that assemble into multiple subcomplexes and form large central channels for nucleocytoplasmic exchange1,2.
M. Allegretti, C. Zimmerli, Vasileios Rantos, F. Wilfling, P. Ronchi, Herman K. H. Fung, Chia-Wei Lee, W. Hagen, Beata Turoňová, Kai Karius, Mandy Börmel, Xiaojie Zhang, C. Müller, Y. Schwab, J. Mahamid, B. Pfander, J. Kosiński, Martin Beck   +17 more
semanticscholar   +1 more source

HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration

bioRxiv, 2021
The capsid (CA) lattice of the HIV-1 core plays a key role during infection. From the moment the core is released into the cytoplasm, it interacts with a range of cellular factors that, ultimately, direct the pre-integration complex to the integration ...
Anabel Guedán, C. Donaldson, O. Cosnefroy, I. Taylor, K. Bishop   +4 more
semanticscholar   +1 more source

Establishment and inheritance of epigenetic transcriptional memory

Frontiers in Molecular Biosciences, 2022
For certain inducible genes, the rate and molecular mechanism of transcriptional activation depends on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation and requires both changes in ...
Bethany Sump, Jason Brickner
doaj   +1 more source

Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells. [PDF]

PLoS ONE, 2011
Tpr is a large coiled-coil protein located in the nuclear basket of the nuclear pore complex for which many different functions were proposed from yeast to human.Here we show that depletion of Tpr by RNA interference triggers G0-G1 arrest and ultimately ...
Brigitte David-Watine
doaj   +1 more source

Nup98-dependent transcriptional memory is established independently of transcription

eLife, 2022
Cellular ability to mount an enhanced transcriptional response upon repeated exposure to external cues is termed transcriptional memory, which can be maintained epigenetically through cell divisions and can depend on a nuclear pore component Nup98.
Pau Pascual-Garcia, Shawn C Little, Maya Capelson   +2 more
doaj   +1 more source

Nuclear pore blockade reveals HIV-1 completes reverse transcription and uncoating in the nucleus

Nature Microbiology, 2020
Retroviral infection involves the reverse transcription of the viral RNA genome into DNA, which is subsequently integrated into the host cell genome. Human immunodeficiency virus type 1 (HIV-1) and other lentiviruses mediate the infection of non-dividing
A. Dharan, N. Bachmann, S. Talley, Virginia Zwikelmaier, E. Campbell   +4 more
semanticscholar   +1 more source

A Homolog of Structural Maintenance of Chromosome 1 Is a Persistent Centromeric Protein Which Associates With Nuclear Pore Components in Toxoplasma gondii

Frontiers in Cellular and Infection Microbiology, 2020
Apicomplexa are obligate intracellular parasites which cause various animal and human diseases including malaria, toxoplasmosis, and cryptosporidiosis. They proliferate by a unique mechanism that combines physically separated semi-closed mitosis of the ...
Maria E. Francia, Sheila Bhavsar, Li-Min Ting, Matthew M. Croken, Kami Kim, Jean-Francois Dubremetz, Boris Striepen, Boris Striepen   +7 more
doaj   +1 more source

Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory

eLife, 2022
For some inducible genes, the rate and molecular mechanism of transcriptional activation depend on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation, and requires both changes in ...
Bethany Sump, Donna G Brickner, Agustina D'Urso, Seo Hyun Kim, Jason H Brickner   +4 more
doaj   +1 more source

Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly [PDF]

, 2011
During mitosis, the nuclear envelope merges with the endoplasmic reticulum (ER), and nuclear pore complexes are disassembled. In a current model for reassembly after mitosis, the nuclear envelope forms by a reshaping of ER tubules.
Anderson, Anderson, Anderson, Antonin, Baumann, Belgareh, Bodoor, Burke, Chaudhary, Comings, Crisp, Cronshaw, Doucet, Drin, Dultz, Dultz, D’Angelo, Ehrlich, Ellenberg, Ferko, Franz, Gillespie, Goldberg, Haraguchi, Haraguchi, Haraguchi, Harel, Hetzer, Kiseleva, Kremer, Lei Lu, Lu, Macaulay, Mark S. Ladinsky, Mastronarde, Mastronarde, Maul, Patel, Puhka, Rabut, Rasala, Rasala, Rotem, Sheehan, Tomas Kirchhausen, Voeltz, Walther, Yang, Zuccolo   +48 more
core   +4 more sources

Poring over pores: nuclear pore complex insertion into the nuclear envelope

Trends in Biochemical Sciences, 2013
The nuclear boundary is formed by the nuclear envelope (NE), a double membrane system that establishes a selective barrier between the nucleoplasm and the cytoplasm. Its barrier characteristics are determined by nuclear pore complexes (NPCs); huge protein assemblies that guard nucleocytoplasmic compartmentalization.
Rothballer Andrea, Kutay Ulrike
openaire   +3 more sources