Results 21 to 30 of about 2,343,531 (340)
Acta Neuropathologica Communications, 2021 Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon characterized by the reduction of specific ...
Alyssa N. Coyne, Jeffrey D. Rothstein
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NMR diffusion pore imaging: Experimental phase detection by double diffusion encoding [PDF]
Phys. Rev. E, 95 (2017) 022404, 2021 Diffusion pore imaging is an extension of diffusion-weighted nuclear magnetic resonance imaging enabling the direct measurement of the shape of arbitrarily formed, closed pores by probing diffusion restrictions using the motion of spin-bearing particles.
arxiv +1 more source
Current Biology, 2003 What are they? Nuclear pore complexes (NPCs) are often referred to as the ‘gatekeepers of the nucleus’, being responsible for regulating the molecular traffic – from ions to ribosomes – between the nucleoplasm and the cytoplasm. A typical vertebrate nucleus has about 5,000 NPCs scattered over its surface.What do they look like? A picture is worth twice
C. Patrick Lusk, Richard W. Wozniak
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Science Translational Medicine, 2021 Nuclear accumulation of CHMP7 leads to multiple cellular pathologies that can be mitigated via CHMP7 ASOs in familial and sporadic ALS iPSNs. Repairing the nuclear pore in ALS The majority of amyotrophic lateral sclerosis (ALS) cases are of unknown ...
Alyssa N. Coyne +7 more
semanticscholar +1 more source
A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis
Open Biology, 2021 The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex (NPC) biogenesis factors Brl1 and Brr6. How Apq12 executes these functions is unknown.
Wanlu Zhang +8 more
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Experimental determination of pore shapes using phase retrieval from q-space NMR diffraction [PDF]
Phys. Rev. E, 97 (2018) 052412, 2021 This paper presents a novel approach on solving the phase problem in nuclear magnetic resonance (NMR) diffusion pore imaging, a method, which allows imaging the shape of arbitrary closed pores filled with an NMR-detectable medium for investigation of the microstructure of biological tissue and porous materials. Classical q-space imaging composed of two
arxiv +1 more source
Cargo transport through the nuclear pore complex at a glance
Journal of Cell Science, 2021 Bidirectional transport of macromolecules across the nuclear envelope is a hallmark of eukaryotic cells, in which the genetic material is compartmentalized inside the nucleus.
G. Paci, Joana Caria, E. Lemke
semanticscholar +1 more source
Some remarks on the discovery of Md-244 [PDF]
Phys. Rev. Lett. 126, 182501 (2021), 2021 In two recent papers by Pore et al. and Khuyagbaatar et al. discovery of the new isotope Md-244 was reported. The decay data, however, are conflicting. While Pore et al. report two isomeric states decaying by alpha emission with E(1)=8.66(2) MeV, T_1/2=0.4+0.4/-0.1s and E(2)=8.31(2) MeV, T_1/2 approx 6 s, Khuyagbaatar et al.
arxiv +1 more source
Glycosylation of the Nuclear Pore [PDF]
Traffic, 2014 The O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) posttranslational modification was first discovered 30 years ago and is highly concentrated in the nuclear pore. In the years since the discovery of this single sugar modification, substantial progress has been made in understanding the biochemistry of O‐GlcNAc and its regulation.
Bin Li, Jennifer J. Kohler
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Generating Membrane Curvature at the Nuclear Pore: A Lipid Point of View
Cells, 2022 In addition to its structural role in enclosing and protecting the genome, the nuclear envelope (NE) forms a highly adaptive communication interface between the cytoplasm and the nuclear interior in eukaryotic cells.
Bas W. A. Peeters +2 more
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