Results 31 to 40 of about 2,343,531 (340)

Nanocompartmentalization of the Nuclear Pore Lumen [PDF]

Biophysical Journal, 2020
The nuclear pore complex (NPC) employs the intrinsically disordered regions (IDRs) from a family of phenylalanine-glycine-rich nucleoporins (FG-Nups) to control nucleocytoplasmic transport. It has been a long-standing mystery how the IDR-mediated mass exchange can be rapid yet selective.
Kai Huang, Mario Tagliazucchi, Sung Hyun Park, Yitzhak Rabin, Igal Szleifer   +4 more
openaire   +4 more sources

In-cell architecture of the nuclear pore and snapshots of its turnover

Nature, 2020
Nuclear pore complexes (NPCs) fuse the inner and outer membranes of the nuclear envelope. They comprise hundreds of nucleoporins (Nups) that assemble into multiple subcomplexes and form large central channels for nucleocytoplasmic exchange1,2.
M. Allegretti, C. Zimmerli, Vasileios Rantos, F. Wilfling, P. Ronchi, Herman K. H. Fung, Chia-Wei Lee, W. Hagen, Beata Turoňová, Kai Karius, Mandy Börmel, Xiaojie Zhang, C. Müller, Y. Schwab, J. Mahamid, B. Pfander, J. Kosiński, Martin Beck   +17 more
semanticscholar   +1 more source

Nuclear pore blockade reveals HIV-1 completes reverse transcription and uncoating in the nucleus

Nature Microbiology, 2020
Retroviral infection involves the reverse transcription of the viral RNA genome into DNA, which is subsequently integrated into the host cell genome. Human immunodeficiency virus type 1 (HIV-1) and other lentiviruses mediate the infection of non-dividing
A. Dharan, N. Bachmann, S. Talley, Virginia Zwikelmaier, E. Campbell   +4 more
semanticscholar   +1 more source

Poring over pores: nuclear pore complex insertion into the nuclear envelope

Trends in Biochemical Sciences, 2013
The nuclear boundary is formed by the nuclear envelope (NE), a double membrane system that establishes a selective barrier between the nucleoplasm and the cytoplasm. Its barrier characteristics are determined by nuclear pore complexes (NPCs); huge protein assemblies that guard nucleocytoplasmic compartmentalization.
Rothballer Andrea, Kutay Ulrike
openaire   +3 more sources

Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly [PDF]

, 2011
During mitosis, the nuclear envelope merges with the endoplasmic reticulum (ER), and nuclear pore complexes are disassembled. In a current model for reassembly after mitosis, the nuclear envelope forms by a reshaping of ER tubules.
Anderson, Anderson, Anderson, Antonin, Baumann, Belgareh, Bodoor, Burke, Chaudhary, Comings, Crisp, Cronshaw, Doucet, Drin, Dultz, Dultz, D’Angelo, Ehrlich, Ellenberg, Ferko, Franz, Gillespie, Goldberg, Haraguchi, Haraguchi, Haraguchi, Harel, Hetzer, Kiseleva, Kremer, Lei Lu, Lu, Macaulay, Mark S. Ladinsky, Mastronarde, Mastronarde, Maul, Patel, Puhka, Rabut, Rasala, Rasala, Rotem, Sheehan, Tomas Kirchhausen, Voeltz, Walther, Yang, Zuccolo   +48 more
core   +4 more sources

The Arabidopsis Nuclear Pore and Nuclear Envelope [PDF]

The Arabidopsis Book, 2010
The nuclear envelope is a double membrane structure that separates the eukaryotic cytoplasm from the nucleoplasm. The nuclear pores embedded in the nuclear envelope are the sole gateways for macromolecular trafficking in and out of the nucleus. The nuclear pore complexes assembled at the nuclear pores are large protein conglomerates composed of ...
Jelena Brkljacic, Iris Meier
openaire   +2 more sources

Pore structure characterization based on joint numerical and experimental study: a case study of Nanpu Sag

Journal of Petroleum Exploration and Production Technology, 2019
Petrophysical properties such as acoustic velocity, resistivity and nuclear magnetic resonance are greatly depending on the pore structures. This is because the pore structures could control the elastic modulus, conductive path and seepage distribution ...
Hatitao Li, Shaogui Deng, Xiyong Yuan, Xufei Hu, Yunfeng Niu   +4 more
doaj   +1 more source

A Homolog of Structural Maintenance of Chromosome 1 Is a Persistent Centromeric Protein Which Associates With Nuclear Pore Components in Toxoplasma gondii

Frontiers in Cellular and Infection Microbiology, 2020
Apicomplexa are obligate intracellular parasites which cause various animal and human diseases including malaria, toxoplasmosis, and cryptosporidiosis. They proliferate by a unique mechanism that combines physically separated semi-closed mitosis of the ...
Maria E. Francia, Sheila Bhavsar, Li-Min Ting, Matthew M. Croken, Kami Kim, Jean-Francois Dubremetz, Boris Striepen, Boris Striepen   +7 more
doaj   +1 more source

Higher nucleoporin-Importinβ affinity at the nuclear basket increases nucleocytoplasmic import. [PDF]

, 2013
Several in vitro studies have shown the presence of an affinity gradient in nuclear pore complex proteins for the import receptor Importinβ, at least partially contributing to nucleocytoplasmic transport, while others have historically argued against the
Azimi, Mohammad, Mofrad, Mohammad
core   +2 more sources

Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore [PDF]

, 2004
Resident integral proteins of the inner nuclear membrane (INM) are synthesized as membrane-integrated proteins on the peripheral endoplasmic reticulum (ER) and are transported to the INM throughout interphase using an unknown trafficking mechanism.
Gerace, Larry, Nishimoto, Takeharu, Ohba, Tomoyuki, Schirmer, Eric C   +3 more
core   +2 more sources