Results 51 to 60 of about 2,343,531 (340)
A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. [PDF]
, 2015 Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/nuclear envelope (ER/NE) lumen. A mutation that markedly impairs torsinA function causes the CNS disorder DYT1 dystonia. Abnormalities of NE membranes have been linked to torsinA
Dauer, William T +4 more
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The Structure of the Nuclear Pore Complex (An Update).
Annual Review of Biochemistry, 2019 The nuclear pore complex (NPC) serves as the sole bidirectional gateway of macromolecules in and out of the nucleus. Owing to its size and complexity (∼1,000 protein subunits, ∼110 MDa in humans), the NPC has remained one of the foremost challenges for ...
D. H. Lin, A. Hoelz
semanticscholar +1 more source
STAR Protocols, 2023 Summary: Nuclear pore complexes are pathways for nuclear-cytoplasmic communication that participate in chromatin organization. Here, we present a protocol to image and quantify the number of nuclear pore complexes in cells.
Jocelyn D. Mich-Basso, Bernhard Kühn
doaj
New Family Members of FG Repeat Proteins and Their Unexplored Roles During Phase Separation
Frontiers in Cell and Developmental Biology, 2021 The condensation and compartmentalization of biomacromolecules in the cell are driven by the process of phase separation. The main effectors of phase separation are intrinsically disordered proteins, which include proteins with a phenylalanine-glycine ...
Yoichi Shinkai +2 more
doaj +1 more source
The Journal of Cell Biology, 1967 Negative staining of isolated nuclear envelopes by phosphotungstate shows that the nuclear pores are octagonal rather than circular. Pores of the same shape and approximately the same width, 663 ± 5 A, were demonstrated in the newt, Triturus, the frog, Rana, and the starfish, Henricia.
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The nuclear pore‐targeting complex binds to nuclear pores after association with a karyophile [PDF]
FEBS Letters, 1995 We recently showed that a karyophilic protein forms a stable complex, termed nuclear pore‐targeting complex (PTAC), with cytoplasmic components prior to nuclear porebinding. In this study, we cloned a cDNA encoding a 97 kDa of PTAC (PTAC97). Recombinant PTAC97 completely reconstitutes the nuclear binding‐step in conjunction with a 58 kDa component of ...
Shingo Kose +8 more
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Role of SAGA in the asymmetric segregation of DNA circles during yeast ageing
eLife, 2014 In eukaryotes, intra-chromosomal recombination generates DNA circles, but little is known about how cells react to them. In yeast, partitioning of such circles to the mother cell at mitosis ensures their loss from the population but promotes replicative ...
Annina Denoth-Lippuner +3 more
doaj +1 more source
TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS
eLife, 2020 Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which disrupted NCT causes neurodegeneration remain unclear.
Kathleen M Cunningham +13 more
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Establishment and inheritance of epigenetic transcriptional memory
Frontiers in Molecular Biosciences, 2022 For certain inducible genes, the rate and molecular mechanism of transcriptional activation depends on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation and requires both changes in ...
Bethany Sump, Jason Brickner
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Nature Communications, 2020 In yeast, collapsed forks shift to the nuclear periphery to associate with two distinct perinuclear anchorage sites such as the nuclear pore complex. Here, the authors reveal the mechanisms engaged at nuclear pore complex facilitating fork integrity and ...
Karol Kramarz +7 more
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