Results 51 to 60 of about 2,248,811 (276)
The Journal of Cell Biology, 1967 Negative staining of isolated nuclear envelopes by phosphotungstate shows that the nuclear pores are octagonal rather than circular. Pores of the same shape and approximately the same width, 663 ± 5 A, were demonstrated in the newt, Triturus, the frog, Rana, and the starfish, Henricia.
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Three-dimensional structure and flexibility of a membrane-coating module of the nuclear pore complex. [PDF]
, 2009 The nuclear pore complex mediates nucleocytoplasmic transport in all eukaryotes and is among the largest cellular assemblies of proteins, collectively known as nucleoporins. Nucleoporins are organized into distinct subcomplexes.
Blobel, Günter, Kampmann, Martin
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Nuclear Envelope: Nuclear Pore Complexity [PDF]
Current Biology, 2005 A new study shows that the filamentous fungus, Aspergillus nidulans, which has a closed mitosis, does not maintain a continuous permeability barrier during mitosis. This work challenges current views of the differences between closed and open mitosis and has implications for understanding mitotic specific changes in the nuclear pore complex and Ran ...
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The nuclear pore‐targeting complex binds to nuclear pores after association with a karyophile [PDF]
FEBS Letters, 1995 We recently showed that a karyophilic protein forms a stable complex, termed nuclear pore‐targeting complex (PTAC), with cytoplasmic components prior to nuclear porebinding. In this study, we cloned a cDNA encoding a 97 kDa of PTAC (PTAC97). Recombinant PTAC97 completely reconstitutes the nuclear binding‐step in conjunction with a 58 kDa component of ...
Shingo Kose +8 more
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An agent-based model for mRNA export through the nuclear pore complex. [PDF]
, 2014 mRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood.
Azimi, Mohammad +3 more
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Integrative Structure and Functional Anatomy of a Nuclear Pore Complex
Nature, 2018 Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have impeded a full structural and functional elucidation.
Seung Joong Kim +31 more
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Nature Communications, 2019 Although defects in nucleocytoplasmic transport (NCT) may be central to the pathogenesis of ALS, the molecular mechanisms modulating the nuclear pore function are still largely unknown.
Anthony Giampetruzzi +8 more
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Nucleus, 2023 In adult mammals, many heart muscle cells (cardiomyocytes) are polyploid, do not proliferate (post-mitotic), and, consequently, cannot contribute to heart regeneration.
Yao Li +3 more
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Structure and Assembly of the Nuclear Pore Complex.
Annual Review of Biophysics, 2019 Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange. They are exceptionally large protein complexes that fuse the inner and outer nuclear membranes to form channels across the nuclear envelope.
Bernhard Hampoelz +3 more
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Nuclear Pore Complex Structure [PDF]
Developmental Cell, 2004 Nuclear pore complexes (NPCs) are large protein assemblies embedded in the nuclear envelope that act as passageways for transport of molecules into and out of the nucleus. Two new studies, one in Nature Cell Biology and one in Science , offer direct evidence that the NPC is a highly dynamic structure.
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